Protective effect of β-glucan and glutamine on intestinal and immunological damage in mice induced by cytarabine (Ara-C)

Detalhes bibliográficos
Autor(a) principal: Porsani,Mariana Y.H.
Data de Publicação: 2017
Outros Autores: Paludetti,Monique, Orlando,Débora R., Peconick,Ana P., Costa,Rafael C., Oliveira,Luiz E.D., Zangeronimo,Márcio G., Sousa,Raimundo V.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Pesquisa Veterinária Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2017000900977
Resumo: ABSTRACT: Recently, glutamine and β-glucan have been demonstrated to play an important role in modulation of the immune system and in promoting intestinal health benefits. The aim of this study was to investigate the effect of this intervention on inflammatory responses and intestinal health in mice orally pretreated with soluble Saccharomyces cerevisiae derived 1,3/1,6-β-glucan (80mg/kg) with or without glutamine (150mg/kg) and then challenged with cytarabine (Ara-C) (15mg/kg). Improvements in villi and crypts were not observed in the β-glucan group. The intestinal morphometry in the glutamine group showed the best results. β-glucan in combination with glutamine presented the highest values of IL-1β and IL-10 and lowest values for leukocytes and INF-γ. Based on these results, combined β-glucan and glutamine pretreatment reduced intestinal inflammation and improved the immune response after Ara-C challenge.
id EMBRAPA-2_5e655c3afeaabd804a6b145b65bc01e7
oai_identifier_str oai:scielo:S0100-736X2017000900977
network_acronym_str EMBRAPA-2
network_name_str Pesquisa Veterinária Brasileira (Online)
repository_id_str
spelling Protective effect of β-glucan and glutamine on intestinal and immunological damage in mice induced by cytarabine (Ara-C)β-glucanglutamineintestineimmunologymicecytarabineAra-Cchemotherapyyeastintestinal healthimmunomodulatorsABSTRACT: Recently, glutamine and β-glucan have been demonstrated to play an important role in modulation of the immune system and in promoting intestinal health benefits. The aim of this study was to investigate the effect of this intervention on inflammatory responses and intestinal health in mice orally pretreated with soluble Saccharomyces cerevisiae derived 1,3/1,6-β-glucan (80mg/kg) with or without glutamine (150mg/kg) and then challenged with cytarabine (Ara-C) (15mg/kg). Improvements in villi and crypts were not observed in the β-glucan group. The intestinal morphometry in the glutamine group showed the best results. β-glucan in combination with glutamine presented the highest values of IL-1β and IL-10 and lowest values for leukocytes and INF-γ. Based on these results, combined β-glucan and glutamine pretreatment reduced intestinal inflammation and improved the immune response after Ara-C challenge.Colégio Brasileiro de Patologia Animal - CBPA2017-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2017000900977Pesquisa Veterinária Brasileira v.37 n.9 2017reponame:Pesquisa Veterinária Brasileira (Online)instname:Colégio Brasileiro de Patologia Animal (CBPA)instacron:EMBRAPA10.1590/s0100-736x2017000900013info:eu-repo/semantics/openAccessPorsani,Mariana Y.H.Paludetti,MoniqueOrlando,Débora R.Peconick,Ana P.Costa,Rafael C.Oliveira,Luiz E.D.Zangeronimo,Márcio G.Sousa,Raimundo V.eng2017-12-05T00:00:00Zoai:scielo:S0100-736X2017000900977Revistahttp://www.pvb.com.br/https://old.scielo.br/oai/scielo-oai.phpcolegio@cbpa.org.br||pvb@pvb.com.br0100-736X1678-5150opendoar:2017-12-05T00:00Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA)false
dc.title.none.fl_str_mv Protective effect of β-glucan and glutamine on intestinal and immunological damage in mice induced by cytarabine (Ara-C)
title Protective effect of β-glucan and glutamine on intestinal and immunological damage in mice induced by cytarabine (Ara-C)
spellingShingle Protective effect of β-glucan and glutamine on intestinal and immunological damage in mice induced by cytarabine (Ara-C)
Porsani,Mariana Y.H.
β-glucan
glutamine
intestine
immunology
mice
cytarabine
Ara-C
chemotherapy
yeast
intestinal health
immunomodulators
title_short Protective effect of β-glucan and glutamine on intestinal and immunological damage in mice induced by cytarabine (Ara-C)
title_full Protective effect of β-glucan and glutamine on intestinal and immunological damage in mice induced by cytarabine (Ara-C)
title_fullStr Protective effect of β-glucan and glutamine on intestinal and immunological damage in mice induced by cytarabine (Ara-C)
title_full_unstemmed Protective effect of β-glucan and glutamine on intestinal and immunological damage in mice induced by cytarabine (Ara-C)
title_sort Protective effect of β-glucan and glutamine on intestinal and immunological damage in mice induced by cytarabine (Ara-C)
author Porsani,Mariana Y.H.
author_facet Porsani,Mariana Y.H.
Paludetti,Monique
Orlando,Débora R.
Peconick,Ana P.
Costa,Rafael C.
Oliveira,Luiz E.D.
Zangeronimo,Márcio G.
Sousa,Raimundo V.
author_role author
author2 Paludetti,Monique
Orlando,Débora R.
Peconick,Ana P.
Costa,Rafael C.
Oliveira,Luiz E.D.
Zangeronimo,Márcio G.
Sousa,Raimundo V.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Porsani,Mariana Y.H.
Paludetti,Monique
Orlando,Débora R.
Peconick,Ana P.
Costa,Rafael C.
Oliveira,Luiz E.D.
Zangeronimo,Márcio G.
Sousa,Raimundo V.
dc.subject.por.fl_str_mv β-glucan
glutamine
intestine
immunology
mice
cytarabine
Ara-C
chemotherapy
yeast
intestinal health
immunomodulators
topic β-glucan
glutamine
intestine
immunology
mice
cytarabine
Ara-C
chemotherapy
yeast
intestinal health
immunomodulators
description ABSTRACT: Recently, glutamine and β-glucan have been demonstrated to play an important role in modulation of the immune system and in promoting intestinal health benefits. The aim of this study was to investigate the effect of this intervention on inflammatory responses and intestinal health in mice orally pretreated with soluble Saccharomyces cerevisiae derived 1,3/1,6-β-glucan (80mg/kg) with or without glutamine (150mg/kg) and then challenged with cytarabine (Ara-C) (15mg/kg). Improvements in villi and crypts were not observed in the β-glucan group. The intestinal morphometry in the glutamine group showed the best results. β-glucan in combination with glutamine presented the highest values of IL-1β and IL-10 and lowest values for leukocytes and INF-γ. Based on these results, combined β-glucan and glutamine pretreatment reduced intestinal inflammation and improved the immune response after Ara-C challenge.
publishDate 2017
dc.date.none.fl_str_mv 2017-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2017000900977
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2017000900977
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/s0100-736x2017000900013
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Colégio Brasileiro de Patologia Animal - CBPA
publisher.none.fl_str_mv Colégio Brasileiro de Patologia Animal - CBPA
dc.source.none.fl_str_mv Pesquisa Veterinária Brasileira v.37 n.9 2017
reponame:Pesquisa Veterinária Brasileira (Online)
instname:Colégio Brasileiro de Patologia Animal (CBPA)
instacron:EMBRAPA
instname_str Colégio Brasileiro de Patologia Animal (CBPA)
instacron_str EMBRAPA
institution EMBRAPA
reponame_str Pesquisa Veterinária Brasileira (Online)
collection Pesquisa Veterinária Brasileira (Online)
repository.name.fl_str_mv Pesquisa Veterinária Brasileira (Online) - Colégio Brasileiro de Patologia Animal (CBPA)
repository.mail.fl_str_mv colegio@cbpa.org.br||pvb@pvb.com.br
_version_ 1754122237457203200

Registros relacionados