Sublethal endpoints in non-target organism testing for insect-active GE crops.

Detalhes bibliográficos
Autor(a) principal: ROBERTS, A.
Data de Publicação: 2020
Outros Autores: BOECKMAN, C. J., MÜHL, M., ROMEIS, J., TEEM, J. L., VALICENTE, F. H., BROWN, J. K., EDWARDS, M. G., LEVINE, S. L., MELNICK, R. L., ROFRIGUES, T. B., VÉLEZ, A. M., ZHOU, X., HELLMICH, R. L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
Texto Completo: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1123519
https://doi.org/10.3389/fbioe.2020.00556
Resumo: Historically, genetically engineered (GE) plants that have incorporated genes conferring insect protection have primarily used Cry proteins derived from Bacillus thuringiensis (Bt) to achieve their insecticidal phenotype. As a result, regulators have developed a level of familiarity and confidence in reviewing plants incorporating these insecticidal proteins. However, new technologies have been developed that produce GE plants that incorporate pest protection by triggering an RNA interference (RNAi) response or proteins other than Bt Cry proteins. These technologies have new modes of action. Although the overall assessment paradigm for GE plants is robust, there are ongoing discussions about the appropriate tests and measurement endpoints needed to inform non-target arthropod assessment for technologies that have a different mode of action than the Bt Cry proteins. As a result, increasing attention is being paid to the use of sublethal endpoints and their value for environmental risk assessment (ERA). This review focuses on the current status and history of sublethal endpoint use in insect-active GE crops, and evaluates the future use of sublethal endpoints for new and emerging technologies. It builds upon presentations made at the Workshop on Sublethal Endpoints for Non-target Organism Testing for Non-Bt GE Crops (Washington DC, USA, 4â??5 March 2019), and the discussions of government, academic and industry scientists convened for the purpose of reviewing the progress and status of sublethal endpoint testing in non-target organisms.
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spelling Sublethal endpoints in non-target organism testing for insect-active GE crops.Organismos não-alvoParâmetros subletaisPlanta geneticamente modificadaMelhoramento Genético VegetalControle BiológicoInsetoPlanta TransgênicaHistorically, genetically engineered (GE) plants that have incorporated genes conferring insect protection have primarily used Cry proteins derived from Bacillus thuringiensis (Bt) to achieve their insecticidal phenotype. As a result, regulators have developed a level of familiarity and confidence in reviewing plants incorporating these insecticidal proteins. However, new technologies have been developed that produce GE plants that incorporate pest protection by triggering an RNA interference (RNAi) response or proteins other than Bt Cry proteins. These technologies have new modes of action. Although the overall assessment paradigm for GE plants is robust, there are ongoing discussions about the appropriate tests and measurement endpoints needed to inform non-target arthropod assessment for technologies that have a different mode of action than the Bt Cry proteins. As a result, increasing attention is being paid to the use of sublethal endpoints and their value for environmental risk assessment (ERA). This review focuses on the current status and history of sublethal endpoint use in insect-active GE crops, and evaluates the future use of sublethal endpoints for new and emerging technologies. It builds upon presentations made at the Workshop on Sublethal Endpoints for Non-target Organism Testing for Non-Bt GE Crops (Washington DC, USA, 4â??5 March 2019), and the discussions of government, academic and industry scientists convened for the purpose of reviewing the progress and status of sublethal endpoint testing in non-target organisms.Andrew Roberts, Agriculture and Food Systems Institute, Washington, DCChad J. Boeckman, Corteva AgriscienceMarina Mühl, Ministerio de Agricultura, Ganadería y Pesca, Dirección de Biotecnología, Buenos AiresJörg Romeis, Research Division Agroecology and Environment, Agroscope, ZurichJohn L. Teem, Agriculture and Food Systems Institute, Washington, DCFERNANDO HERCOS VALICENTE, CNPMSJudith K. Brown, School of Plant Sciences, The University of Arizona, TucsonMartin G. Edwards, School of Natural and Environmental Sciences, Newcastle University, Newcastle upon TyneSteven L. Levine, Bayer Crop Science, Chesterfield, MORachel L. Melnick, Agriculture and Food Systems Institute, Washington, DCThais B. Rodrigues, Greenlight Biosciences, Inc., Medford, MAAna M. Vélez, Department of Entomology, University of Nebraska-LincolnXuguo Zhou, Department of Entomology, University of Kentucky, Lexington, KYRichard L. Hellmich, USDA, Corn Insects and Crop Genetics Research Unit, Ames.ROBERTS, A.BOECKMAN, C. J.MÜHL, M.ROMEIS, J.TEEM, J. L.VALICENTE, F. H.BROWN, J. K.EDWARDS, M. G.LEVINE, S. L.MELNICK, R. L.ROFRIGUES, T. B.VÉLEZ, A. M.ZHOU, X.HELLMICH, R. L.2020-07-01T11:10:59Z2020-07-01T11:10:59Z2020-06-302020info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFrontiers in Bioengineering and Biotechnology, v. 8, article 556, 2020.http://www.alice.cnptia.embrapa.br/alice/handle/doc/1123519https://doi.org/10.3389/fbioe.2020.00556enginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)instacron:EMBRAPA2020-07-01T11:11:08Zoai:www.alice.cnptia.embrapa.br:doc/1123519Repositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestopendoar:21542020-07-01T11:11:08falseRepositório InstitucionalPUBhttps://www.alice.cnptia.embrapa.br/oai/requestcg-riaa@embrapa.bropendoar:21542020-07-01T11:11:08Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)false
dc.title.none.fl_str_mv Sublethal endpoints in non-target organism testing for insect-active GE crops.
title Sublethal endpoints in non-target organism testing for insect-active GE crops.
spellingShingle Sublethal endpoints in non-target organism testing for insect-active GE crops.
ROBERTS, A.
Organismos não-alvo
Parâmetros subletais
Planta geneticamente modificada
Melhoramento Genético Vegetal
Controle Biológico
Inseto
Planta Transgênica
title_short Sublethal endpoints in non-target organism testing for insect-active GE crops.
title_full Sublethal endpoints in non-target organism testing for insect-active GE crops.
title_fullStr Sublethal endpoints in non-target organism testing for insect-active GE crops.
title_full_unstemmed Sublethal endpoints in non-target organism testing for insect-active GE crops.
title_sort Sublethal endpoints in non-target organism testing for insect-active GE crops.
author ROBERTS, A.
author_facet ROBERTS, A.
BOECKMAN, C. J.
MÜHL, M.
ROMEIS, J.
TEEM, J. L.
VALICENTE, F. H.
BROWN, J. K.
EDWARDS, M. G.
LEVINE, S. L.
MELNICK, R. L.
ROFRIGUES, T. B.
VÉLEZ, A. M.
ZHOU, X.
HELLMICH, R. L.
author_role author
author2 BOECKMAN, C. J.
MÜHL, M.
ROMEIS, J.
TEEM, J. L.
VALICENTE, F. H.
BROWN, J. K.
EDWARDS, M. G.
LEVINE, S. L.
MELNICK, R. L.
ROFRIGUES, T. B.
VÉLEZ, A. M.
ZHOU, X.
HELLMICH, R. L.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Andrew Roberts, Agriculture and Food Systems Institute, Washington, DC
Chad J. Boeckman, Corteva Agriscience
Marina Mühl, Ministerio de Agricultura, Ganadería y Pesca, Dirección de Biotecnología, Buenos Aires
Jörg Romeis, Research Division Agroecology and Environment, Agroscope, Zurich
John L. Teem, Agriculture and Food Systems Institute, Washington, DC
FERNANDO HERCOS VALICENTE, CNPMS
Judith K. Brown, School of Plant Sciences, The University of Arizona, Tucson
Martin G. Edwards, School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne
Steven L. Levine, Bayer Crop Science, Chesterfield, MO
Rachel L. Melnick, Agriculture and Food Systems Institute, Washington, DC
Thais B. Rodrigues, Greenlight Biosciences, Inc., Medford, MA
Ana M. Vélez, Department of Entomology, University of Nebraska-Lincoln
Xuguo Zhou, Department of Entomology, University of Kentucky, Lexington, KY
Richard L. Hellmich, USDA, Corn Insects and Crop Genetics Research Unit, Ames.
dc.contributor.author.fl_str_mv ROBERTS, A.
BOECKMAN, C. J.
MÜHL, M.
ROMEIS, J.
TEEM, J. L.
VALICENTE, F. H.
BROWN, J. K.
EDWARDS, M. G.
LEVINE, S. L.
MELNICK, R. L.
ROFRIGUES, T. B.
VÉLEZ, A. M.
ZHOU, X.
HELLMICH, R. L.
dc.subject.por.fl_str_mv Organismos não-alvo
Parâmetros subletais
Planta geneticamente modificada
Melhoramento Genético Vegetal
Controle Biológico
Inseto
Planta Transgênica
topic Organismos não-alvo
Parâmetros subletais
Planta geneticamente modificada
Melhoramento Genético Vegetal
Controle Biológico
Inseto
Planta Transgênica
description Historically, genetically engineered (GE) plants that have incorporated genes conferring insect protection have primarily used Cry proteins derived from Bacillus thuringiensis (Bt) to achieve their insecticidal phenotype. As a result, regulators have developed a level of familiarity and confidence in reviewing plants incorporating these insecticidal proteins. However, new technologies have been developed that produce GE plants that incorporate pest protection by triggering an RNA interference (RNAi) response or proteins other than Bt Cry proteins. These technologies have new modes of action. Although the overall assessment paradigm for GE plants is robust, there are ongoing discussions about the appropriate tests and measurement endpoints needed to inform non-target arthropod assessment for technologies that have a different mode of action than the Bt Cry proteins. As a result, increasing attention is being paid to the use of sublethal endpoints and their value for environmental risk assessment (ERA). This review focuses on the current status and history of sublethal endpoint use in insect-active GE crops, and evaluates the future use of sublethal endpoints for new and emerging technologies. It builds upon presentations made at the Workshop on Sublethal Endpoints for Non-target Organism Testing for Non-Bt GE Crops (Washington DC, USA, 4â??5 March 2019), and the discussions of government, academic and industry scientists convened for the purpose of reviewing the progress and status of sublethal endpoint testing in non-target organisms.
publishDate 2020
dc.date.none.fl_str_mv 2020-07-01T11:10:59Z
2020-07-01T11:10:59Z
2020-06-30
2020
dc.type.driver.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv Frontiers in Bioengineering and Biotechnology, v. 8, article 556, 2020.
http://www.alice.cnptia.embrapa.br/alice/handle/doc/1123519
https://doi.org/10.3389/fbioe.2020.00556
identifier_str_mv Frontiers in Bioengineering and Biotechnology, v. 8, article 556, 2020.
url http://www.alice.cnptia.embrapa.br/alice/handle/doc/1123519
https://doi.org/10.3389/fbioe.2020.00556
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
instname:Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
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instname_str Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
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repository.name.fl_str_mv Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice) - Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
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