Association of vitamin B in schizophrenia

• Autor(a) principal: Soares, Juliana Veras
• Data de Publicação: 2020
• Outros Autores: Capelo, Melissa Figueiredo, Sanford, Ana Beatriz Aguiar, Mesquita, Dara da Silva, Honório Júnior, José Eduardo Ribeiro
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Scire Salutis
• Texto Completo: https://sustenere.inf.br/index.php/sciresalutis/article/view/CBPC2236-9600.2021.001.0009
• topic: Esquizofrenia; Complexo B; Vitamina B; Espectro de Esquizofrenia; Schizophrenia; Complex B; Vitamin B; Schizophrenia Spectrum

Schizophrenia is a serious neuropsychiatric disorder that not only causes a great deal of disease, but also challenges our understanding of how the mind and brain work. Schizophrenia affects around 1% of the world population, just in Brazil more than 2 million people suffer from this disorder and according to the Brazilian Psychiatric Association, the disease is prevalent in males and is usually not diagnosed at the beginning. The diagnosis is based on a constellation of clinical symptoms and not on a common pathomechanism. Vitamins are organic compounds, needed in small amounts for normal metabolism and that cannot be manufactured by the cells of the body. Water-soluble substances are absorbed by the intestine and transported through the circulatory system to the tissues in which they will be used, they are not stored and are easily excreted by the kidneys, so they must be ingested daily, in this group are vitamins B. The B complex can be used as coenzymes in macronutrient catabolism to produce energy for the human body. Research shows that ancillary treatment with B vitamins at a high dose - including B6, B8 and B12 - can significantly reduce symptoms of treatments more than standard schizophrenia alone. A bibliographic search was made using the Google academic databases, Scielo, Pubmed and Lilacs, with schizophrenia, B complex, vitamin B and schizophrenia spectrum as descriptors. 21 articles were included that met the inclusion criteria. In conclusion, the administration of vitamins B6, B9 and B12 had positive results in relation to memory and negative symptoms of schizophrenic patients, it is also necessary to develop a new animal model, since the use of the current one for the study of schizophrenia has not yet it's efficient.