Negative Correlation between Placental Growth Factor and Endocan-1 in Women with Preeclampsia
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista brasileira de ginecologia e obstetrícia (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032018001000593 |
Resumo: | Abstract Objective To analyze endocan-1, a biomarker of vascular endothelial related pathologies, and the placental growth factor (PlGF), an angiogenic factor and a placental dysfunction marker in patients with preeclampsia (PE). Methods Case-control study conducted at Hospital São Lucas, in the city of Porto Alegre, Brazil. Endocan-1 and PlGF levels were quantified in the maternal plasma using the MagPlexTH-C microsphere system (MAGPIX System, Luminex, Austin, Texas, US) and evaluated through analysis of covariance (ANCOVA) and adjusted by body mass index (BMI), gestational age and maternal age. To estimate the difference between the groups, the mean ratio (MR) and the 95% confidence interval (95%CI) were calculated. The Pearson correlation test was used to establish any association between endocan-1 and PlGF levels. The null hypothesis was rejected when p < 0.05. Results The group of patients was composed by normotensive (n = 67) patients and patients with PE (n = 50). A negative correlation between endocan-1 and the PlGF was noted in the entire normotensive group (linear correlation coefficient [r] = -0.605; p < 0.001), as well as in the PE group (r = -0.545; p < 0.001). Conclusion Endocan-1 levels are increased in patients with PE, and are inversely correlated with PlGF levels. We suggest that it is important to analyze angiogenic and proinflammatory molecules concomitantly in women with PE to better understand the pathophysiology of the disease. Both molecules are strong candidates for PE biomarkers, and future studies will examine any mechanisms connecting these factors in PE. |
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Negative Correlation between Placental Growth Factor and Endocan-1 in Women with Preeclampsiapregnancy-induced hypertensionpreeclampsiaendothelial functionbiomarkerscytokinesAbstract Objective To analyze endocan-1, a biomarker of vascular endothelial related pathologies, and the placental growth factor (PlGF), an angiogenic factor and a placental dysfunction marker in patients with preeclampsia (PE). Methods Case-control study conducted at Hospital São Lucas, in the city of Porto Alegre, Brazil. Endocan-1 and PlGF levels were quantified in the maternal plasma using the MagPlexTH-C microsphere system (MAGPIX System, Luminex, Austin, Texas, US) and evaluated through analysis of covariance (ANCOVA) and adjusted by body mass index (BMI), gestational age and maternal age. To estimate the difference between the groups, the mean ratio (MR) and the 95% confidence interval (95%CI) were calculated. The Pearson correlation test was used to establish any association between endocan-1 and PlGF levels. The null hypothesis was rejected when p < 0.05. Results The group of patients was composed by normotensive (n = 67) patients and patients with PE (n = 50). A negative correlation between endocan-1 and the PlGF was noted in the entire normotensive group (linear correlation coefficient [r] = -0.605; p < 0.001), as well as in the PE group (r = -0.545; p < 0.001). Conclusion Endocan-1 levels are increased in patients with PE, and are inversely correlated with PlGF levels. We suggest that it is important to analyze angiogenic and proinflammatory molecules concomitantly in women with PE to better understand the pathophysiology of the disease. Both molecules are strong candidates for PE biomarkers, and future studies will examine any mechanisms connecting these factors in PE.Federação Brasileira das Sociedades de Ginecologia e Obstetrícia2018-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032018001000593Revista Brasileira de Ginecologia e Obstetrícia v.40 n.10 2018reponame:Revista brasileira de ginecologia e obstetrícia (Online)instname:Federação Brasileira das Sociedades de Ginecologia e Obstetrícia (FEBRASGO)instacron:FEBRASGO10.1055/s-0038-1670713info:eu-repo/semantics/openAccessHentschke,Marta RibeiroCunha Filho,Edson Vieira daVieira,Matias CostaPaula,Letícia GermanyMistry,Hiten D.Costa,Bartira Ercília Pinheiro daPoli-de-Figueiredo,Carlos Eduardoeng2018-11-21T00:00:00Zoai:scielo:S0100-72032018001000593Revistahttp://www.scielo.br/rbgohttps://old.scielo.br/oai/scielo-oai.phppublicações@febrasgo.org.br||rbgo@fmrp.usp.br1806-93390100-7203opendoar:2018-11-21T00:00Revista brasileira de ginecologia e obstetrícia (Online) - Federação Brasileira das Sociedades de Ginecologia e Obstetrícia (FEBRASGO)false |
dc.title.none.fl_str_mv |
Negative Correlation between Placental Growth Factor and Endocan-1 in Women with Preeclampsia |
title |
Negative Correlation between Placental Growth Factor and Endocan-1 in Women with Preeclampsia |
spellingShingle |
Negative Correlation between Placental Growth Factor and Endocan-1 in Women with Preeclampsia Hentschke,Marta Ribeiro pregnancy-induced hypertension preeclampsia endothelial function biomarkers cytokines |
title_short |
Negative Correlation between Placental Growth Factor and Endocan-1 in Women with Preeclampsia |
title_full |
Negative Correlation between Placental Growth Factor and Endocan-1 in Women with Preeclampsia |
title_fullStr |
Negative Correlation between Placental Growth Factor and Endocan-1 in Women with Preeclampsia |
title_full_unstemmed |
Negative Correlation between Placental Growth Factor and Endocan-1 in Women with Preeclampsia |
title_sort |
Negative Correlation between Placental Growth Factor and Endocan-1 in Women with Preeclampsia |
author |
Hentschke,Marta Ribeiro |
author_facet |
Hentschke,Marta Ribeiro Cunha Filho,Edson Vieira da Vieira,Matias Costa Paula,Letícia Germany Mistry,Hiten D. Costa,Bartira Ercília Pinheiro da Poli-de-Figueiredo,Carlos Eduardo |
author_role |
author |
author2 |
Cunha Filho,Edson Vieira da Vieira,Matias Costa Paula,Letícia Germany Mistry,Hiten D. Costa,Bartira Ercília Pinheiro da Poli-de-Figueiredo,Carlos Eduardo |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Hentschke,Marta Ribeiro Cunha Filho,Edson Vieira da Vieira,Matias Costa Paula,Letícia Germany Mistry,Hiten D. Costa,Bartira Ercília Pinheiro da Poli-de-Figueiredo,Carlos Eduardo |
dc.subject.por.fl_str_mv |
pregnancy-induced hypertension preeclampsia endothelial function biomarkers cytokines |
topic |
pregnancy-induced hypertension preeclampsia endothelial function biomarkers cytokines |
description |
Abstract Objective To analyze endocan-1, a biomarker of vascular endothelial related pathologies, and the placental growth factor (PlGF), an angiogenic factor and a placental dysfunction marker in patients with preeclampsia (PE). Methods Case-control study conducted at Hospital São Lucas, in the city of Porto Alegre, Brazil. Endocan-1 and PlGF levels were quantified in the maternal plasma using the MagPlexTH-C microsphere system (MAGPIX System, Luminex, Austin, Texas, US) and evaluated through analysis of covariance (ANCOVA) and adjusted by body mass index (BMI), gestational age and maternal age. To estimate the difference between the groups, the mean ratio (MR) and the 95% confidence interval (95%CI) were calculated. The Pearson correlation test was used to establish any association between endocan-1 and PlGF levels. The null hypothesis was rejected when p < 0.05. Results The group of patients was composed by normotensive (n = 67) patients and patients with PE (n = 50). A negative correlation between endocan-1 and the PlGF was noted in the entire normotensive group (linear correlation coefficient [r] = -0.605; p < 0.001), as well as in the PE group (r = -0.545; p < 0.001). Conclusion Endocan-1 levels are increased in patients with PE, and are inversely correlated with PlGF levels. We suggest that it is important to analyze angiogenic and proinflammatory molecules concomitantly in women with PE to better understand the pathophysiology of the disease. Both molecules are strong candidates for PE biomarkers, and future studies will examine any mechanisms connecting these factors in PE. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032018001000593 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032018001000593 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1055/s-0038-1670713 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Federação Brasileira das Sociedades de Ginecologia e Obstetrícia |
publisher.none.fl_str_mv |
Federação Brasileira das Sociedades de Ginecologia e Obstetrícia |
dc.source.none.fl_str_mv |
Revista Brasileira de Ginecologia e Obstetrícia v.40 n.10 2018 reponame:Revista brasileira de ginecologia e obstetrícia (Online) instname:Federação Brasileira das Sociedades de Ginecologia e Obstetrícia (FEBRASGO) instacron:FEBRASGO |
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Federação Brasileira das Sociedades de Ginecologia e Obstetrícia (FEBRASGO) |
instacron_str |
FEBRASGO |
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FEBRASGO |
reponame_str |
Revista brasileira de ginecologia e obstetrícia (Online) |
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Revista brasileira de ginecologia e obstetrícia (Online) |
repository.name.fl_str_mv |
Revista brasileira de ginecologia e obstetrícia (Online) - Federação Brasileira das Sociedades de Ginecologia e Obstetrícia (FEBRASGO) |
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publicações@febrasgo.org.br||rbgo@fmrp.usp.br |
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