Sirtuin 1 Levels in Recurrent Implantation Failure

• Autor(a) principal: Engin-Ustun,Yaprak
• Data de Publicação: 2017
• Outros Autores: Ozgu-Erdinc,A. Seval, Caglayan,Emel Kiyak, Gulerman,Cavidan, Sarikaya,Esma, Aktulay,Ayla, Demirtas,Canan, Erkaya,Salim, Yilmaz,Nafiye
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista brasileira de ginecologia e obstetrícia (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032017001000541
• topic: recurrent implantation failure; sirtuin;pregnancy;in vitro fertilization

Abstract Sirtuin 1 has an important role in cellular processes, including apoptosis and cellular stress. The purpose of this study was to assess serum sirtuin 1 levels in women with recurrent implantation failure (RIF). In this cross-sectional study, we included 28 women with RIF, 29 healthy women who had conceived by in vitro fertilization (IVF), and 30 women with a 1-cycle failure of IVF as controls. Human serum nicotinamide adenine dinucleotide (NAD)-dependent deacetylase sirtuin-1 (SIRT1/SIRT2L1) levels were detected using a commercial colorimetric kit. Recurrent implantation failure patients have higher sirtuin 1 levels than non-pregnant women and healthy pregnant women, but this difference did not reach statistical significance due to the low number of patients in our study. These higher sirtuin 1 levels may result from the inflammation imbalance of RIF patients. The only statistically significant correlation found was between age and sirtuin (r = 0.277, p = 0.009).