Acute oral toxicity and assessment of blood pressure and kidney effects caused by oncocalyxone A

• Autor(a) principal: Silva, Paula Letícia Braga e
• Data de Publicação: 2021
• Outros Autores: Costa, Laura Lícia Marcos da, Nogueira Júnior, Francisco Assis, Jorge, Antônio Rafael Coelho, Pereira, Jeanine Morais, Evangelista, Janaina Serra Azul Monteiro, Pessoa, Otília Deusdênia Loiola, Alves, Renata Sousa, Monteiro, Helena Serra Azul
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista Fitos
• Texto Completo: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/973
• topic: Oncocalyxona A; Toxicidade oral aguda; Perfusão renal; Alterações histológicas; Oncocalyxone-A; Acute oral toxicity; Renal perfusion; Histological changes

This study proposes to evaluate the toxicological, pressure and renal effects of onco-A in animal models in vivo and ex vivo. The Oncocalyxone-A (onco-A), isolated of Auxemma oncocalyx, was studied in doses of 1, 3 and 10 µg/mL. Female Swiss mice were used (20-25g) for the acute oral toxicity test. The data were compared by test t de Student, Two-Way ANOVA and post-test Bonferroni (p<0,05). The oral toxicity was considered low since it showed a DL50 ˃ 2000 mg/kg. Histological alterations on lung, renal and cardiac tissues were observed. About levels blood pressure of rats, the onco-A caused a significant reduction of mean arterial pressure, altered creatinine levels and, histological changes in cardiac and renal tissues. In isolated kidney perfusion onco-A caused an increase in perfusion pressure urinary flow and renal vascular resistance. The rate of glomerular filtration was reduced in concentrations 1 µg /mL and 10 µg/mL increasing the dose to 3 μg / mL. Photomicrographs of renal tissue after perfusion demonstrated significant histological changes induced by onco-A. It can be inferred that, although onco-A has presented low lethality in all experimental protocols performed, showed evidence of pulmonary, renal and cardiac toxicity.