Natural Products as HIV Reverse Transcriptase Inhibitors

Detalhes bibliográficos
Autor(a) principal: Souza, M. V. N.
Data de Publicação: 2009
Outros Autores: Gonçalves, R. S. B., Barreto, M. B., Gomes, C. R. B.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Fitos
Texto Completo: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/89
Resumo: Currently available anti-HIV drugs can be classified into six categories: (a) nucleoside analogue reverse transcriptase inhibitors (NRTIs), (b) non-nucleoside reverse transcriptase inhibitors (NNRTIs), (c) protease inhibitors (PIs), (d) fusion inhibitors (IFs), (e) entry inhibitors (EIs) and (f) integrase inhibitors (IIs). Due to the rapid spread of HIV strains resistant to all the major anti-HIV drugs on the market, we urgently need to develop new drugs to fight against AIDS. In this context, due to the importance of nature in the development of new drugs, the aim of the present review is to highlight a series of new and promising anti-HIV agents derived from natural products virus acting on reverse transcriptase enzyme, which are essential for HIV replication.
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spelling Natural Products as HIV Reverse Transcriptase InhibitorsProdutos Naturais Inibidores da Transcriptase Reversa do Vírus HIVCurrently available anti-HIV drugs can be classified into six categories: (a) nucleoside analogue reverse transcriptase inhibitors (NRTIs), (b) non-nucleoside reverse transcriptase inhibitors (NNRTIs), (c) protease inhibitors (PIs), (d) fusion inhibitors (IFs), (e) entry inhibitors (EIs) and (f) integrase inhibitors (IIs). Due to the rapid spread of HIV strains resistant to all the major anti-HIV drugs on the market, we urgently need to develop new drugs to fight against AIDS. In this context, due to the importance of nature in the development of new drugs, the aim of the present review is to highlight a series of new and promising anti-HIV agents derived from natural products virus acting on reverse transcriptase enzyme, which are essential for HIV replication.Atualmente, os fármacos disponíveis no combate ao vírus da AIDS podem ser classificados em seis categorias: (a) inibidores da transcriptase reversa análogos de nucleosídeos (ITRNs), (b) inibidores da transcriptase reversa não nucleosídeos (ITRNNs), (c) inibidores de protease (IPs), (d) inibidores de fusão (IFs), (e) inibidores de entrada (IEs) e (f) inibidores da integrase (IIs). Devido à rápida disseminação do vírus HIV resistente aos diversos fármacos disponíveis no mercado, é necessário e urgente o desenvolvimento de novos fármacos na luta contra a AIDS. Neste contexto, o objetivo desse artigo é destacar promissores produtos naturais capazes de atuar na enzima trascriptase reversa, a qual é essencial para a replicação do vírus HIV.Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz2009-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdftext/htmlhttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/8910.32712/2446-4775.2009.89Revista Fitos; Vol. 4 No. 01 (2009); 87-107Revista Fitos; Vol. 4 Núm. 01 (2009); 87-107Revista Fitos; v. 4 n. 01 (2009); 87-1072446-47751808-9569reponame:Revista Fitosinstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZporhttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/89/88https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/89/1230Copyright (c) 2009 Revista Fitos Eletrônicainfo:eu-repo/semantics/openAccessSouza, M. V. N.Gonçalves, R. S. B.Barreto, M. B.Gomes, C. R. B.2022-10-19T19:01:57Zoai:ojs.revistafitos.far.fiocruz.br:article/89Revistahttps://revistafitos.far.fiocruz.br/index.php/revista-fitos/PUBhttp://revistafitos.far.fiocruz.br/index.php/revista-fitos/oairevistafitos@far.fiocruz.br || eugenio.telles@far.fiocruz.br2446-47752446-4775opendoar:2022-10-19T19:01:57Revista Fitos - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.none.fl_str_mv Natural Products as HIV Reverse Transcriptase Inhibitors
Produtos Naturais Inibidores da Transcriptase Reversa do Vírus HIV
title Natural Products as HIV Reverse Transcriptase Inhibitors
spellingShingle Natural Products as HIV Reverse Transcriptase Inhibitors
Souza, M. V. N.
title_short Natural Products as HIV Reverse Transcriptase Inhibitors
title_full Natural Products as HIV Reverse Transcriptase Inhibitors
title_fullStr Natural Products as HIV Reverse Transcriptase Inhibitors
title_full_unstemmed Natural Products as HIV Reverse Transcriptase Inhibitors
title_sort Natural Products as HIV Reverse Transcriptase Inhibitors
author Souza, M. V. N.
author_facet Souza, M. V. N.
Gonçalves, R. S. B.
Barreto, M. B.
Gomes, C. R. B.
author_role author
author2 Gonçalves, R. S. B.
Barreto, M. B.
Gomes, C. R. B.
author2_role author
author
author
dc.contributor.author.fl_str_mv Souza, M. V. N.
Gonçalves, R. S. B.
Barreto, M. B.
Gomes, C. R. B.
description Currently available anti-HIV drugs can be classified into six categories: (a) nucleoside analogue reverse transcriptase inhibitors (NRTIs), (b) non-nucleoside reverse transcriptase inhibitors (NNRTIs), (c) protease inhibitors (PIs), (d) fusion inhibitors (IFs), (e) entry inhibitors (EIs) and (f) integrase inhibitors (IIs). Due to the rapid spread of HIV strains resistant to all the major anti-HIV drugs on the market, we urgently need to develop new drugs to fight against AIDS. In this context, due to the importance of nature in the development of new drugs, the aim of the present review is to highlight a series of new and promising anti-HIV agents derived from natural products virus acting on reverse transcriptase enzyme, which are essential for HIV replication.
publishDate 2009
dc.date.none.fl_str_mv 2009-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/89
10.32712/2446-4775.2009.89
url https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/89
identifier_str_mv 10.32712/2446-4775.2009.89
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/89/88
https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/89/1230
dc.rights.driver.fl_str_mv Copyright (c) 2009 Revista Fitos Eletrônica
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2009 Revista Fitos Eletrônica
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
text/html
dc.publisher.none.fl_str_mv Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz
publisher.none.fl_str_mv Centro de Inovação em Biodiversidade e Saúde - Farmanguinhos/Fiocruz
dc.source.none.fl_str_mv Revista Fitos; Vol. 4 No. 01 (2009); 87-107
Revista Fitos; Vol. 4 Núm. 01 (2009); 87-107
Revista Fitos; v. 4 n. 01 (2009); 87-107
2446-4775
1808-9569
reponame:Revista Fitos
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Revista Fitos
collection Revista Fitos
repository.name.fl_str_mv Revista Fitos - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv revistafitos@far.fiocruz.br || eugenio.telles@far.fiocruz.br
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