Trypanosoma cruzi infection in offspring born to chagasic C3H/He mice

Detalhes bibliográficos
Autor(a) principal: Araújo,Silvana Marques de
Data de Publicação: 1996
Outros Autores: Chiari,Egler
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761996000200017
Resumo: This study reports the effects of Trypanosoma cruzi infection induced in C3H/He male and female mice born to chagasic mice. An experimental model was established infecting female C3H/He mice with a low virulent T. cruzi clone. In this model, mating, fertilization, pregnancy evolution and delivery was carried out successfully. The offspring was infected at four, six and eigth weeks of age. The results showed that the offspring born to chagasic mothers present decreased resistance to acquired T. cruzi infection. This decreased resistance was expressed by higher levels of parasitaemia and higher mortality rates in offspring born to chagasic mothers than in controls. Age and sex were shown to be important factors of this phenomenon. The results suggest that maternal immune system products can modulate the immune response of the offspring.
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spelling Trypanosoma cruzi infection in offspring born to chagasic C3H/He micematernal influencedecreased resistancematernal-fetal relationshipTrypanosoma cruziThis study reports the effects of Trypanosoma cruzi infection induced in C3H/He male and female mice born to chagasic mice. An experimental model was established infecting female C3H/He mice with a low virulent T. cruzi clone. In this model, mating, fertilization, pregnancy evolution and delivery was carried out successfully. The offspring was infected at four, six and eigth weeks of age. The results showed that the offspring born to chagasic mothers present decreased resistance to acquired T. cruzi infection. This decreased resistance was expressed by higher levels of parasitaemia and higher mortality rates in offspring born to chagasic mothers than in controls. Age and sex were shown to be important factors of this phenomenon. The results suggest that maternal immune system products can modulate the immune response of the offspring.Instituto Oswaldo Cruz, Ministério da Saúde1996-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761996000200017Memórias do Instituto Oswaldo Cruz v.91 n.2 1996reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02761996000200017info:eu-repo/semantics/openAccessAraújo,Silvana Marques deChiari,Eglereng2020-04-25T17:47:32Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:06:56.523Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Trypanosoma cruzi infection in offspring born to chagasic C3H/He mice
title Trypanosoma cruzi infection in offspring born to chagasic C3H/He mice
spellingShingle Trypanosoma cruzi infection in offspring born to chagasic C3H/He mice
Araújo,Silvana Marques de
maternal influence
decreased resistance
maternal-fetal relationship
Trypanosoma cruzi
title_short Trypanosoma cruzi infection in offspring born to chagasic C3H/He mice
title_full Trypanosoma cruzi infection in offspring born to chagasic C3H/He mice
title_fullStr Trypanosoma cruzi infection in offspring born to chagasic C3H/He mice
title_full_unstemmed Trypanosoma cruzi infection in offspring born to chagasic C3H/He mice
title_sort Trypanosoma cruzi infection in offspring born to chagasic C3H/He mice
author Araújo,Silvana Marques de
author_facet Araújo,Silvana Marques de
Chiari,Egler
author_role author
author2 Chiari,Egler
author2_role author
dc.contributor.author.fl_str_mv Araújo,Silvana Marques de
Chiari,Egler
dc.subject.por.fl_str_mv maternal influence
decreased resistance
maternal-fetal relationship
Trypanosoma cruzi
topic maternal influence
decreased resistance
maternal-fetal relationship
Trypanosoma cruzi
dc.description.none.fl_txt_mv This study reports the effects of Trypanosoma cruzi infection induced in C3H/He male and female mice born to chagasic mice. An experimental model was established infecting female C3H/He mice with a low virulent T. cruzi clone. In this model, mating, fertilization, pregnancy evolution and delivery was carried out successfully. The offspring was infected at four, six and eigth weeks of age. The results showed that the offspring born to chagasic mothers present decreased resistance to acquired T. cruzi infection. This decreased resistance was expressed by higher levels of parasitaemia and higher mortality rates in offspring born to chagasic mothers than in controls. Age and sex were shown to be important factors of this phenomenon. The results suggest that maternal immune system products can modulate the immune response of the offspring.
description This study reports the effects of Trypanosoma cruzi infection induced in C3H/He male and female mice born to chagasic mice. An experimental model was established infecting female C3H/He mice with a low virulent T. cruzi clone. In this model, mating, fertilization, pregnancy evolution and delivery was carried out successfully. The offspring was infected at four, six and eigth weeks of age. The results showed that the offspring born to chagasic mothers present decreased resistance to acquired T. cruzi infection. This decreased resistance was expressed by higher levels of parasitaemia and higher mortality rates in offspring born to chagasic mothers than in controls. Age and sex were shown to be important factors of this phenomenon. The results suggest that maternal immune system products can modulate the immune response of the offspring.
publishDate 1996
dc.date.none.fl_str_mv 1996-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761996000200017
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761996000200017
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02761996000200017
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.91 n.2 1996
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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