Inflammatory cutaneous reaction induced by the lectin of Dioclea grandiflora (Mart. )

Detalhes bibliográficos
Autor(a) principal: Lima,M. Silva
Data de Publicação: 1993
Outros Autores: Albuquerque,D. A., Ibañez,O. M., Sant'anna,O.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761993000400018
Resumo: The lectin from Dioclea grandiflora (Mart.) that selectively binds glucose and mannose, when subcutaneously injected in mouse induces an inflammatory cutaneous reaction whose histological analysis reveals an hemorrhagic ulceration with exudative reaction accompanied by an influx of polymorphonuclear leukocytes and giant cells. The presence of lymphocytes and plasma cells in the lesion was insignificant. In order to characterize the in vivo action of inflammatory factors generated by this lesion, distinct lines of mice were used: high and low antibody responder mice; the genetically selected mice to the acute phase of inflammatory reaction; lines of mice deficient in C5, a protein of the complement system. It is shown that the lectin of D. grandiflora acts as an inflammatory agent probably promoting exocytosis and release of mediators.
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spelling Inflammatory cutaneous reaction induced by the lectin of Dioclea grandiflora (Mart. )Dioclea grandiflora lectininflammatory reactioncutaneous lesionThe lectin from Dioclea grandiflora (Mart.) that selectively binds glucose and mannose, when subcutaneously injected in mouse induces an inflammatory cutaneous reaction whose histological analysis reveals an hemorrhagic ulceration with exudative reaction accompanied by an influx of polymorphonuclear leukocytes and giant cells. The presence of lymphocytes and plasma cells in the lesion was insignificant. In order to characterize the in vivo action of inflammatory factors generated by this lesion, distinct lines of mice were used: high and low antibody responder mice; the genetically selected mice to the acute phase of inflammatory reaction; lines of mice deficient in C5, a protein of the complement system. It is shown that the lectin of D. grandiflora acts as an inflammatory agent probably promoting exocytosis and release of mediators.Instituto Oswaldo Cruz, Ministério da Saúde1993-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761993000400018Memórias do Instituto Oswaldo Cruz v.88 n.4 1993reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02761993000400018info:eu-repo/semantics/openAccessLima,M. SilvaAlbuquerque,D. A.Ibañez,O. M.Sant'anna,O.eng2020-04-25T17:47:11Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:05:49.035Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Inflammatory cutaneous reaction induced by the lectin of Dioclea grandiflora (Mart. )
title Inflammatory cutaneous reaction induced by the lectin of Dioclea grandiflora (Mart. )
spellingShingle Inflammatory cutaneous reaction induced by the lectin of Dioclea grandiflora (Mart. )
Lima,M. Silva
Dioclea grandiflora lectin
inflammatory reaction
cutaneous lesion
title_short Inflammatory cutaneous reaction induced by the lectin of Dioclea grandiflora (Mart. )
title_full Inflammatory cutaneous reaction induced by the lectin of Dioclea grandiflora (Mart. )
title_fullStr Inflammatory cutaneous reaction induced by the lectin of Dioclea grandiflora (Mart. )
title_full_unstemmed Inflammatory cutaneous reaction induced by the lectin of Dioclea grandiflora (Mart. )
title_sort Inflammatory cutaneous reaction induced by the lectin of Dioclea grandiflora (Mart. )
author Lima,M. Silva
author_facet Lima,M. Silva
Albuquerque,D. A.
Ibañez,O. M.
Sant'anna,O.
author_role author
author2 Albuquerque,D. A.
Ibañez,O. M.
Sant'anna,O.
author2_role author
author
author
dc.contributor.author.fl_str_mv Lima,M. Silva
Albuquerque,D. A.
Ibañez,O. M.
Sant'anna,O.
dc.subject.por.fl_str_mv Dioclea grandiflora lectin
inflammatory reaction
cutaneous lesion
topic Dioclea grandiflora lectin
inflammatory reaction
cutaneous lesion
dc.description.none.fl_txt_mv The lectin from Dioclea grandiflora (Mart.) that selectively binds glucose and mannose, when subcutaneously injected in mouse induces an inflammatory cutaneous reaction whose histological analysis reveals an hemorrhagic ulceration with exudative reaction accompanied by an influx of polymorphonuclear leukocytes and giant cells. The presence of lymphocytes and plasma cells in the lesion was insignificant. In order to characterize the in vivo action of inflammatory factors generated by this lesion, distinct lines of mice were used: high and low antibody responder mice; the genetically selected mice to the acute phase of inflammatory reaction; lines of mice deficient in C5, a protein of the complement system. It is shown that the lectin of D. grandiflora acts as an inflammatory agent probably promoting exocytosis and release of mediators.
description The lectin from Dioclea grandiflora (Mart.) that selectively binds glucose and mannose, when subcutaneously injected in mouse induces an inflammatory cutaneous reaction whose histological analysis reveals an hemorrhagic ulceration with exudative reaction accompanied by an influx of polymorphonuclear leukocytes and giant cells. The presence of lymphocytes and plasma cells in the lesion was insignificant. In order to characterize the in vivo action of inflammatory factors generated by this lesion, distinct lines of mice were used: high and low antibody responder mice; the genetically selected mice to the acute phase of inflammatory reaction; lines of mice deficient in C5, a protein of the complement system. It is shown that the lectin of D. grandiflora acts as an inflammatory agent probably promoting exocytosis and release of mediators.
publishDate 1993
dc.date.none.fl_str_mv 1993-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761993000400018
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761993000400018
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02761993000400018
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.88 n.4 1993
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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