Dried blood spots as a practical and inexpensive source for human immunodeficiency virus and hepatitis C virus surveillance
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Memórias do Instituto Oswaldo Cruz |
Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000400005 |
Resumo: | Passive surveillance of infectious diseases with a high percentage of asymptomatic cases or long incubation periods, such as acquired immunodeficiency syndrome (AIDS), does not reflect the current transmission dynamics. Thus, a multi-strategic surveillance, such as the human immunodeficiency virus (HIV) sentinel surveillance proposed by the World Health Organization (WHO), is necessary. The Brazilian HIV sentinel surveillance was started in May 1992 with this purpose. The objectives of this study were to evaluate the feasibility and costs of HIV and hepatitis C virus (HCV) surveillance using dried blood spots (DBS) collected for neonatal screening of metabolic diseases in the state of Minas Gerais, Brazil. This was accomplished through the comparison of HIV and HCV seroprevalence with previous Brazilian studies. From December 2001 to June 2002, 24,905 newborns were tested for HIV and 4211 for HCV. HIV seroprevalence was 0.25% and the 95% confidence interval (CI) was 0.18, 0.31%; and HCV seroprevalence was 0.71% and the 95% CI was 0.46, 0.97%. These numbers are similar to previous Brazilian studies. Cost in this study was approximately US$ 3.10 per sample, which was roughly one third of the cost of the same exam at the Brazilian HIV sentinel surveillance. We conclude that it is possible and more cost-effective to use DBS for infectious diseases surveillance, albeit it is still necessary to compare these results with the usual sentinel methodology in a concomitant trial. |
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Dried blood spots as a practical and inexpensive source for human immunodeficiency virus and hepatitis C virus surveillancehuman immunodeficiency virus seroprevalencehepatitis Csentinel surveillanceinfectious diseasePassive surveillance of infectious diseases with a high percentage of asymptomatic cases or long incubation periods, such as acquired immunodeficiency syndrome (AIDS), does not reflect the current transmission dynamics. Thus, a multi-strategic surveillance, such as the human immunodeficiency virus (HIV) sentinel surveillance proposed by the World Health Organization (WHO), is necessary. The Brazilian HIV sentinel surveillance was started in May 1992 with this purpose. The objectives of this study were to evaluate the feasibility and costs of HIV and hepatitis C virus (HCV) surveillance using dried blood spots (DBS) collected for neonatal screening of metabolic diseases in the state of Minas Gerais, Brazil. This was accomplished through the comparison of HIV and HCV seroprevalence with previous Brazilian studies. From December 2001 to June 2002, 24,905 newborns were tested for HIV and 4211 for HCV. HIV seroprevalence was 0.25% and the 95% confidence interval (CI) was 0.18, 0.31%; and HCV seroprevalence was 0.71% and the 95% CI was 0.46, 0.97%. These numbers are similar to previous Brazilian studies. Cost in this study was approximately US$ 3.10 per sample, which was roughly one third of the cost of the same exam at the Brazilian HIV sentinel surveillance. We conclude that it is possible and more cost-effective to use DBS for infectious diseases surveillance, albeit it is still necessary to compare these results with the usual sentinel methodology in a concomitant trial.Instituto Oswaldo Cruz, Ministério da Saúde2005-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000400005Memórias do Instituto Oswaldo Cruz v.100 n.4 2005reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762005000400005info:eu-repo/semantics/openAccessToledo Jr.,Antonio Carlos de CastroJanuário,José NélioRezende,Renata Maria SilvaSiqueira,Arminda LúciaMello,Bernardo Freire deFialho,Érica LigorioRibeiro,Raquel AndradeSilva,Hélia Lemos daPires,Érika CarvalhoSimões,Taynaná CésarGreco,Dirceu Bartolomeueng2020-04-25T17:49:24Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:13:10.489Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue |
dc.title.none.fl_str_mv |
Dried blood spots as a practical and inexpensive source for human immunodeficiency virus and hepatitis C virus surveillance |
title |
Dried blood spots as a practical and inexpensive source for human immunodeficiency virus and hepatitis C virus surveillance |
spellingShingle |
Dried blood spots as a practical and inexpensive source for human immunodeficiency virus and hepatitis C virus surveillance Toledo Jr.,Antonio Carlos de Castro human immunodeficiency virus seroprevalence hepatitis C sentinel surveillance infectious disease |
title_short |
Dried blood spots as a practical and inexpensive source for human immunodeficiency virus and hepatitis C virus surveillance |
title_full |
Dried blood spots as a practical and inexpensive source for human immunodeficiency virus and hepatitis C virus surveillance |
title_fullStr |
Dried blood spots as a practical and inexpensive source for human immunodeficiency virus and hepatitis C virus surveillance |
title_full_unstemmed |
Dried blood spots as a practical and inexpensive source for human immunodeficiency virus and hepatitis C virus surveillance |
title_sort |
Dried blood spots as a practical and inexpensive source for human immunodeficiency virus and hepatitis C virus surveillance |
author |
Toledo Jr.,Antonio Carlos de Castro |
author_facet |
Toledo Jr.,Antonio Carlos de Castro Januário,José Nélio Rezende,Renata Maria Silva Siqueira,Arminda Lúcia Mello,Bernardo Freire de Fialho,Érica Ligorio Ribeiro,Raquel Andrade Silva,Hélia Lemos da Pires,Érika Carvalho Simões,Taynaná César Greco,Dirceu Bartolomeu |
author_role |
author |
author2 |
Januário,José Nélio Rezende,Renata Maria Silva Siqueira,Arminda Lúcia Mello,Bernardo Freire de Fialho,Érica Ligorio Ribeiro,Raquel Andrade Silva,Hélia Lemos da Pires,Érika Carvalho Simões,Taynaná César Greco,Dirceu Bartolomeu |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Toledo Jr.,Antonio Carlos de Castro Januário,José Nélio Rezende,Renata Maria Silva Siqueira,Arminda Lúcia Mello,Bernardo Freire de Fialho,Érica Ligorio Ribeiro,Raquel Andrade Silva,Hélia Lemos da Pires,Érika Carvalho Simões,Taynaná César Greco,Dirceu Bartolomeu |
dc.subject.por.fl_str_mv |
human immunodeficiency virus seroprevalence hepatitis C sentinel surveillance infectious disease |
topic |
human immunodeficiency virus seroprevalence hepatitis C sentinel surveillance infectious disease |
dc.description.none.fl_txt_mv |
Passive surveillance of infectious diseases with a high percentage of asymptomatic cases or long incubation periods, such as acquired immunodeficiency syndrome (AIDS), does not reflect the current transmission dynamics. Thus, a multi-strategic surveillance, such as the human immunodeficiency virus (HIV) sentinel surveillance proposed by the World Health Organization (WHO), is necessary. The Brazilian HIV sentinel surveillance was started in May 1992 with this purpose. The objectives of this study were to evaluate the feasibility and costs of HIV and hepatitis C virus (HCV) surveillance using dried blood spots (DBS) collected for neonatal screening of metabolic diseases in the state of Minas Gerais, Brazil. This was accomplished through the comparison of HIV and HCV seroprevalence with previous Brazilian studies. From December 2001 to June 2002, 24,905 newborns were tested for HIV and 4211 for HCV. HIV seroprevalence was 0.25% and the 95% confidence interval (CI) was 0.18, 0.31%; and HCV seroprevalence was 0.71% and the 95% CI was 0.46, 0.97%. These numbers are similar to previous Brazilian studies. Cost in this study was approximately US$ 3.10 per sample, which was roughly one third of the cost of the same exam at the Brazilian HIV sentinel surveillance. We conclude that it is possible and more cost-effective to use DBS for infectious diseases surveillance, albeit it is still necessary to compare these results with the usual sentinel methodology in a concomitant trial. |
description |
Passive surveillance of infectious diseases with a high percentage of asymptomatic cases or long incubation periods, such as acquired immunodeficiency syndrome (AIDS), does not reflect the current transmission dynamics. Thus, a multi-strategic surveillance, such as the human immunodeficiency virus (HIV) sentinel surveillance proposed by the World Health Organization (WHO), is necessary. The Brazilian HIV sentinel surveillance was started in May 1992 with this purpose. The objectives of this study were to evaluate the feasibility and costs of HIV and hepatitis C virus (HCV) surveillance using dried blood spots (DBS) collected for neonatal screening of metabolic diseases in the state of Minas Gerais, Brazil. This was accomplished through the comparison of HIV and HCV seroprevalence with previous Brazilian studies. From December 2001 to June 2002, 24,905 newborns were tested for HIV and 4211 for HCV. HIV seroprevalence was 0.25% and the 95% confidence interval (CI) was 0.18, 0.31%; and HCV seroprevalence was 0.71% and the 95% CI was 0.46, 0.97%. These numbers are similar to previous Brazilian studies. Cost in this study was approximately US$ 3.10 per sample, which was roughly one third of the cost of the same exam at the Brazilian HIV sentinel surveillance. We conclude that it is possible and more cost-effective to use DBS for infectious diseases surveillance, albeit it is still necessary to compare these results with the usual sentinel methodology in a concomitant trial. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005-07-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000400005 |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762005000400005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0074-02762005000400005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
dc.source.none.fl_str_mv |
Memórias do Instituto Oswaldo Cruz v.100 n.4 2005 reponame:Memórias do Instituto Oswaldo Cruz instname:Fundação Oswaldo Cruz instacron:FIOCRUZ |
reponame_str |
Memórias do Instituto Oswaldo Cruz |
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Memórias do Instituto Oswaldo Cruz |
instname_str |
Fundação Oswaldo Cruz |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
repository.name.fl_str_mv |
Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz |
repository.mail.fl_str_mv |
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