Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Memórias do Instituto Oswaldo Cruz |
Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762006000800012 |
Resumo: | Capillaria hepatica causes two main lesions in the liver of rats: multifocal chronic inflammation, directly related to the presence of disintegrating parasites and their eggs, and a process of systematized septal fibrosis. The comparative behavior of these two lesions was investigated in rats experimentally infected with 600 embryonated eggs, following either corticosteroid treatment or specific antigenic stimulation, in an attempt to understand the relationship between these two lesions, and the pathogenesis of septal fibrosis. The two treatments differently modified the morphological aspects of the focal parasitic-related lesions, but did not interfere with the presentation of diffuse septal fibrosis, although a mild decrease in the degree of fibrosis occurred in corticoid-treated animals. These findings indicate that although the two lesions are C. hepatica induced, they are under different pathogenetic control, the induction of septal fibrosis being triggered during early infection to follow an independent pathway. |
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Memórias do Instituto Oswaldo Cruz |
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Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent coursesCapillaria hepaticaseptal fibrosisratscorticosteroidsantigenic stimulationCapillaria hepatica causes two main lesions in the liver of rats: multifocal chronic inflammation, directly related to the presence of disintegrating parasites and their eggs, and a process of systematized septal fibrosis. The comparative behavior of these two lesions was investigated in rats experimentally infected with 600 embryonated eggs, following either corticosteroid treatment or specific antigenic stimulation, in an attempt to understand the relationship between these two lesions, and the pathogenesis of septal fibrosis. The two treatments differently modified the morphological aspects of the focal parasitic-related lesions, but did not interfere with the presentation of diffuse septal fibrosis, although a mild decrease in the degree of fibrosis occurred in corticoid-treated animals. These findings indicate that although the two lesions are C. hepatica induced, they are under different pathogenetic control, the induction of septal fibrosis being triggered during early infection to follow an independent pathway.Instituto Oswaldo Cruz, Ministério da Saúde2006-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762006000800012Memórias do Instituto Oswaldo Cruz v.101 n.8 2006reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762006000800012info:eu-repo/semantics/openAccessGomes,Ana TherezaCunha,Liliane MonteiroBastos,Carla GuimarãesMedrado,Bruno FredericoAssis,Bárbara CAAndrade,Zilton Aeng2020-04-25T17:49:40Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:14:04.401Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue |
dc.title.none.fl_str_mv |
Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses |
title |
Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses |
spellingShingle |
Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses Gomes,Ana Thereza Capillaria hepatica septal fibrosis rats corticosteroids antigenic stimulation |
title_short |
Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses |
title_full |
Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses |
title_fullStr |
Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses |
title_full_unstemmed |
Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses |
title_sort |
Capillaria hepatica in rats: focal parasitic hepatic lesions and septal fibrosis run independent courses |
author |
Gomes,Ana Thereza |
author_facet |
Gomes,Ana Thereza Cunha,Liliane Monteiro Bastos,Carla Guimarães Medrado,Bruno Frederico Assis,Bárbara CA Andrade,Zilton A |
author_role |
author |
author2 |
Cunha,Liliane Monteiro Bastos,Carla Guimarães Medrado,Bruno Frederico Assis,Bárbara CA Andrade,Zilton A |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Gomes,Ana Thereza Cunha,Liliane Monteiro Bastos,Carla Guimarães Medrado,Bruno Frederico Assis,Bárbara CA Andrade,Zilton A |
dc.subject.por.fl_str_mv |
Capillaria hepatica septal fibrosis rats corticosteroids antigenic stimulation |
topic |
Capillaria hepatica septal fibrosis rats corticosteroids antigenic stimulation |
dc.description.none.fl_txt_mv |
Capillaria hepatica causes two main lesions in the liver of rats: multifocal chronic inflammation, directly related to the presence of disintegrating parasites and their eggs, and a process of systematized septal fibrosis. The comparative behavior of these two lesions was investigated in rats experimentally infected with 600 embryonated eggs, following either corticosteroid treatment or specific antigenic stimulation, in an attempt to understand the relationship between these two lesions, and the pathogenesis of septal fibrosis. The two treatments differently modified the morphological aspects of the focal parasitic-related lesions, but did not interfere with the presentation of diffuse septal fibrosis, although a mild decrease in the degree of fibrosis occurred in corticoid-treated animals. These findings indicate that although the two lesions are C. hepatica induced, they are under different pathogenetic control, the induction of septal fibrosis being triggered during early infection to follow an independent pathway. |
description |
Capillaria hepatica causes two main lesions in the liver of rats: multifocal chronic inflammation, directly related to the presence of disintegrating parasites and their eggs, and a process of systematized septal fibrosis. The comparative behavior of these two lesions was investigated in rats experimentally infected with 600 embryonated eggs, following either corticosteroid treatment or specific antigenic stimulation, in an attempt to understand the relationship between these two lesions, and the pathogenesis of septal fibrosis. The two treatments differently modified the morphological aspects of the focal parasitic-related lesions, but did not interfere with the presentation of diffuse septal fibrosis, although a mild decrease in the degree of fibrosis occurred in corticoid-treated animals. These findings indicate that although the two lesions are C. hepatica induced, they are under different pathogenetic control, the induction of septal fibrosis being triggered during early infection to follow an independent pathway. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762006000800012 |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762006000800012 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0074-02762006000800012 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
dc.source.none.fl_str_mv |
Memórias do Instituto Oswaldo Cruz v.101 n.8 2006 reponame:Memórias do Instituto Oswaldo Cruz instname:Fundação Oswaldo Cruz instacron:FIOCRUZ |
reponame_str |
Memórias do Instituto Oswaldo Cruz |
collection |
Memórias do Instituto Oswaldo Cruz |
instname_str |
Fundação Oswaldo Cruz |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
repository.name.fl_str_mv |
Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz |
repository.mail.fl_str_mv |
|
_version_ |
1669937697170391040 |