High fat diet has a prominent effect upon the course of chronic schistosomiasis mansoni in mice
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Memórias do Instituto Oswaldo Cruz |
Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000400013 |
Resumo: | This study investigated whether a long-term high-fat diet has an effect on the outcome of chronic murine schistosomiasis mansoni compared to a standard diet. Swiss Webster female mice (3 weeks old) were fed each diet for up to six months and were then infected with 50 Schistosoma mansoni cercariae. Their nutritional status was assessed by monitoring total serum cholesterol and body mass. Infected mice were examined 6-17 weeks post infection to estimate the number of eggs in faeces. Mice were euthanised the next day. Total serum cholesterol was lower in infected mice in comparison to uninfected controls (p = 0.0055). In contrast, body mass (p = 0.003), liver volume (p = 0.0405), spleen volume (p = 0.0124), lung volume (p = 0.0033) and faecal (p = 0.0064) and tissue egg density (p = 0.0002) were significantly higher for infected mice fed a high-fat diet. From these findings, it is suggested that a high-fat diet has a prominent effect on the course of chronic schistosomiasis mansoni in mice. |
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Memórias do Instituto Oswaldo Cruz |
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High fat diet has a prominent effect upon the course of chronic schistosomiasis mansoni in miceSchistosoma mansonicholesterolchronic phaseThis study investigated whether a long-term high-fat diet has an effect on the outcome of chronic murine schistosomiasis mansoni compared to a standard diet. Swiss Webster female mice (3 weeks old) were fed each diet for up to six months and were then infected with 50 Schistosoma mansoni cercariae. Their nutritional status was assessed by monitoring total serum cholesterol and body mass. Infected mice were examined 6-17 weeks post infection to estimate the number of eggs in faeces. Mice were euthanised the next day. Total serum cholesterol was lower in infected mice in comparison to uninfected controls (p = 0.0055). In contrast, body mass (p = 0.003), liver volume (p = 0.0405), spleen volume (p = 0.0124), lung volume (p = 0.0033) and faecal (p = 0.0064) and tissue egg density (p = 0.0002) were significantly higher for infected mice fed a high-fat diet. From these findings, it is suggested that a high-fat diet has a prominent effect on the course of chronic schistosomiasis mansoni in mice.Instituto Oswaldo Cruz, Ministério da Saúde2009-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000400013Memórias do Instituto Oswaldo Cruz v.104 n.4 2009reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762009000400013info:eu-repo/semantics/openAccessAlencar,Alba Cristina Miranda de BarrosNeves,Renata HeislerÁguila,Márcia BarbosaMandarim-de-Lacerda,Carlos AlbertoGomes,Delir CorrêaMachado-Silva,José Robertoeng2020-04-25T17:50:29Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:16:15.609Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue |
dc.title.none.fl_str_mv |
High fat diet has a prominent effect upon the course of chronic schistosomiasis mansoni in mice |
title |
High fat diet has a prominent effect upon the course of chronic schistosomiasis mansoni in mice |
spellingShingle |
High fat diet has a prominent effect upon the course of chronic schistosomiasis mansoni in mice Alencar,Alba Cristina Miranda de Barros Schistosoma mansoni cholesterol chronic phase |
title_short |
High fat diet has a prominent effect upon the course of chronic schistosomiasis mansoni in mice |
title_full |
High fat diet has a prominent effect upon the course of chronic schistosomiasis mansoni in mice |
title_fullStr |
High fat diet has a prominent effect upon the course of chronic schistosomiasis mansoni in mice |
title_full_unstemmed |
High fat diet has a prominent effect upon the course of chronic schistosomiasis mansoni in mice |
title_sort |
High fat diet has a prominent effect upon the course of chronic schistosomiasis mansoni in mice |
author |
Alencar,Alba Cristina Miranda de Barros |
author_facet |
Alencar,Alba Cristina Miranda de Barros Neves,Renata Heisler Águila,Márcia Barbosa Mandarim-de-Lacerda,Carlos Alberto Gomes,Delir Corrêa Machado-Silva,José Roberto |
author_role |
author |
author2 |
Neves,Renata Heisler Águila,Márcia Barbosa Mandarim-de-Lacerda,Carlos Alberto Gomes,Delir Corrêa Machado-Silva,José Roberto |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Alencar,Alba Cristina Miranda de Barros Neves,Renata Heisler Águila,Márcia Barbosa Mandarim-de-Lacerda,Carlos Alberto Gomes,Delir Corrêa Machado-Silva,José Roberto |
dc.subject.por.fl_str_mv |
Schistosoma mansoni cholesterol chronic phase |
topic |
Schistosoma mansoni cholesterol chronic phase |
dc.description.none.fl_txt_mv |
This study investigated whether a long-term high-fat diet has an effect on the outcome of chronic murine schistosomiasis mansoni compared to a standard diet. Swiss Webster female mice (3 weeks old) were fed each diet for up to six months and were then infected with 50 Schistosoma mansoni cercariae. Their nutritional status was assessed by monitoring total serum cholesterol and body mass. Infected mice were examined 6-17 weeks post infection to estimate the number of eggs in faeces. Mice were euthanised the next day. Total serum cholesterol was lower in infected mice in comparison to uninfected controls (p = 0.0055). In contrast, body mass (p = 0.003), liver volume (p = 0.0405), spleen volume (p = 0.0124), lung volume (p = 0.0033) and faecal (p = 0.0064) and tissue egg density (p = 0.0002) were significantly higher for infected mice fed a high-fat diet. From these findings, it is suggested that a high-fat diet has a prominent effect on the course of chronic schistosomiasis mansoni in mice. |
description |
This study investigated whether a long-term high-fat diet has an effect on the outcome of chronic murine schistosomiasis mansoni compared to a standard diet. Swiss Webster female mice (3 weeks old) were fed each diet for up to six months and were then infected with 50 Schistosoma mansoni cercariae. Their nutritional status was assessed by monitoring total serum cholesterol and body mass. Infected mice were examined 6-17 weeks post infection to estimate the number of eggs in faeces. Mice were euthanised the next day. Total serum cholesterol was lower in infected mice in comparison to uninfected controls (p = 0.0055). In contrast, body mass (p = 0.003), liver volume (p = 0.0405), spleen volume (p = 0.0124), lung volume (p = 0.0033) and faecal (p = 0.0064) and tissue egg density (p = 0.0002) were significantly higher for infected mice fed a high-fat diet. From these findings, it is suggested that a high-fat diet has a prominent effect on the course of chronic schistosomiasis mansoni in mice. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-07-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000400013 |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000400013 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0074-02762009000400013 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
dc.source.none.fl_str_mv |
Memórias do Instituto Oswaldo Cruz v.104 n.4 2009 reponame:Memórias do Instituto Oswaldo Cruz instname:Fundação Oswaldo Cruz instacron:FIOCRUZ |
reponame_str |
Memórias do Instituto Oswaldo Cruz |
collection |
Memórias do Instituto Oswaldo Cruz |
instname_str |
Fundação Oswaldo Cruz |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
repository.name.fl_str_mv |
Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz |
repository.mail.fl_str_mv |
|
_version_ |
1669937705488744448 |