Plasmodium coatneyi-infected rhesus monkeys: a primate modelfor human cerebral malaria
Autor(a) principal: | |
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Data de Publicação: | 1992 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Memórias do Instituto Oswaldo Cruz |
Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000700074 |
Resumo: | Although several animal models for human cerebral malaria have been proposed in the past, name have shown pathological findings that are similar to those seen in humans. In order to develop an animal model for human cerebral malaria, we studied the pathology of brains of Plasmodium coatneyi (primate malaria parasite)-infected rhesus monkeys. Our study demonstrated parazitized erythrocyte (PRBC) sequestration and cytoadherence of knobs on PRBC to endothelial cells in cerebral microvessels of these monkeys. This similar to the findings een in human cerebral malaria. Crebral microvessels with sequestred PRBC were shown by immunohistochemistry to possess CD36, TSP and ICAM-1. These proteins were not evident in cerebral microvessels of uninfected control monkeys. Our study indicates, for the first time, that rhesus monkeys infected with P. coatneyi can be used as a primate model to study human cerebral malaria. |
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Memórias do Instituto Oswaldo Cruz |
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Plasmodium coatneyi-infected rhesus monkeys: a primate modelfor human cerebral malariaPlasmodium coatneyihuman cerebral malariaanimal modelpathologyrhesus monkeysbrainAlthough several animal models for human cerebral malaria have been proposed in the past, name have shown pathological findings that are similar to those seen in humans. In order to develop an animal model for human cerebral malaria, we studied the pathology of brains of Plasmodium coatneyi (primate malaria parasite)-infected rhesus monkeys. Our study demonstrated parazitized erythrocyte (PRBC) sequestration and cytoadherence of knobs on PRBC to endothelial cells in cerebral microvessels of these monkeys. This similar to the findings een in human cerebral malaria. Crebral microvessels with sequestred PRBC were shown by immunohistochemistry to possess CD36, TSP and ICAM-1. These proteins were not evident in cerebral microvessels of uninfected control monkeys. Our study indicates, for the first time, that rhesus monkeys infected with P. coatneyi can be used as a primate model to study human cerebral malaria.Instituto Oswaldo Cruz, Ministério da Saúde1992-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000700074Memórias do Instituto Oswaldo Cruz v.87 suppl.3 1992reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02761992000700074info:eu-repo/semantics/openAccessAikawa,MasamichiBrown,Arthur E.Smith,C. DahlemTegoshi,TatsuyaHoward,Russell J.Hasler,Thomas H.Ito,YoshihiroColins,William E.Webster,H. Kyleeng2020-04-25T17:47:00Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:05:14.94Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue |
dc.title.none.fl_str_mv |
Plasmodium coatneyi-infected rhesus monkeys: a primate modelfor human cerebral malaria |
title |
Plasmodium coatneyi-infected rhesus monkeys: a primate modelfor human cerebral malaria |
spellingShingle |
Plasmodium coatneyi-infected rhesus monkeys: a primate modelfor human cerebral malaria Aikawa,Masamichi Plasmodium coatneyi human cerebral malaria animal model pathology rhesus monkeys brain |
title_short |
Plasmodium coatneyi-infected rhesus monkeys: a primate modelfor human cerebral malaria |
title_full |
Plasmodium coatneyi-infected rhesus monkeys: a primate modelfor human cerebral malaria |
title_fullStr |
Plasmodium coatneyi-infected rhesus monkeys: a primate modelfor human cerebral malaria |
title_full_unstemmed |
Plasmodium coatneyi-infected rhesus monkeys: a primate modelfor human cerebral malaria |
title_sort |
Plasmodium coatneyi-infected rhesus monkeys: a primate modelfor human cerebral malaria |
author |
Aikawa,Masamichi |
author_facet |
Aikawa,Masamichi Brown,Arthur E. Smith,C. Dahlem Tegoshi,Tatsuya Howard,Russell J. Hasler,Thomas H. Ito,Yoshihiro Colins,William E. Webster,H. Kyle |
author_role |
author |
author2 |
Brown,Arthur E. Smith,C. Dahlem Tegoshi,Tatsuya Howard,Russell J. Hasler,Thomas H. Ito,Yoshihiro Colins,William E. Webster,H. Kyle |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Aikawa,Masamichi Brown,Arthur E. Smith,C. Dahlem Tegoshi,Tatsuya Howard,Russell J. Hasler,Thomas H. Ito,Yoshihiro Colins,William E. Webster,H. Kyle |
dc.subject.por.fl_str_mv |
Plasmodium coatneyi human cerebral malaria animal model pathology rhesus monkeys brain |
topic |
Plasmodium coatneyi human cerebral malaria animal model pathology rhesus monkeys brain |
dc.description.none.fl_txt_mv |
Although several animal models for human cerebral malaria have been proposed in the past, name have shown pathological findings that are similar to those seen in humans. In order to develop an animal model for human cerebral malaria, we studied the pathology of brains of Plasmodium coatneyi (primate malaria parasite)-infected rhesus monkeys. Our study demonstrated parazitized erythrocyte (PRBC) sequestration and cytoadherence of knobs on PRBC to endothelial cells in cerebral microvessels of these monkeys. This similar to the findings een in human cerebral malaria. Crebral microvessels with sequestred PRBC were shown by immunohistochemistry to possess CD36, TSP and ICAM-1. These proteins were not evident in cerebral microvessels of uninfected control monkeys. Our study indicates, for the first time, that rhesus monkeys infected with P. coatneyi can be used as a primate model to study human cerebral malaria. |
description |
Although several animal models for human cerebral malaria have been proposed in the past, name have shown pathological findings that are similar to those seen in humans. In order to develop an animal model for human cerebral malaria, we studied the pathology of brains of Plasmodium coatneyi (primate malaria parasite)-infected rhesus monkeys. Our study demonstrated parazitized erythrocyte (PRBC) sequestration and cytoadherence of knobs on PRBC to endothelial cells in cerebral microvessels of these monkeys. This similar to the findings een in human cerebral malaria. Crebral microvessels with sequestred PRBC were shown by immunohistochemistry to possess CD36, TSP and ICAM-1. These proteins were not evident in cerebral microvessels of uninfected control monkeys. Our study indicates, for the first time, that rhesus monkeys infected with P. coatneyi can be used as a primate model to study human cerebral malaria. |
publishDate |
1992 |
dc.date.none.fl_str_mv |
1992-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000700074 |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761992000700074 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0074-02761992000700074 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
dc.source.none.fl_str_mv |
Memórias do Instituto Oswaldo Cruz v.87 suppl.3 1992 reponame:Memórias do Instituto Oswaldo Cruz instname:Fundação Oswaldo Cruz instacron:FIOCRUZ |
reponame_str |
Memórias do Instituto Oswaldo Cruz |
collection |
Memórias do Instituto Oswaldo Cruz |
instname_str |
Fundação Oswaldo Cruz |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
repository.name.fl_str_mv |
Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz |
repository.mail.fl_str_mv |
|
_version_ |
1669937660543631360 |