Diagnosis of Chagas disease: what has been achieved? What remains to be done with regard to diagnosis and follow up studies?
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Memórias do Instituto Oswaldo Cruz |
Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000900017 |
Resumo: | In the acute phase and in the chronic forms of Chagas disease, the etiological diagnosis may be performed by detection of the parasite using direct or indirect parasitological methods and by the presence of antibodies in the serum by way of serological tests. Several techniques are easily available, ranging from the simplest wet smear preparation to immuno-enzymatic assays with recombinant antigens that will meet most diagnostic needs. Other tests under evaluation include a molecular test using polymerase chain reaction, which has shown promising results and may be used as a confirmatory test both in the acute and chronic phases of the disease. Better rapid tests are needed for diagnosis, some of which are already under evaluation. Additionally, there is a need for tools that can identify patients cured shortly after specific treatment. Other needs include a marker for prognosis and early diagnosis of congenital transmission. |
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Memórias do Instituto Oswaldo Cruz |
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Diagnosis of Chagas disease: what has been achieved? What remains to be done with regard to diagnosis and follow up studies?Chagas diseaseTrypanosoma cruzietiological diagnosisIn the acute phase and in the chronic forms of Chagas disease, the etiological diagnosis may be performed by detection of the parasite using direct or indirect parasitological methods and by the presence of antibodies in the serum by way of serological tests. Several techniques are easily available, ranging from the simplest wet smear preparation to immuno-enzymatic assays with recombinant antigens that will meet most diagnostic needs. Other tests under evaluation include a molecular test using polymerase chain reaction, which has shown promising results and may be used as a confirmatory test both in the acute and chronic phases of the disease. Better rapid tests are needed for diagnosis, some of which are already under evaluation. Additionally, there is a need for tools that can identify patients cured shortly after specific treatment. Other needs include a marker for prognosis and early diagnosis of congenital transmission.Instituto Oswaldo Cruz, Ministério da Saúde2009-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000900017Memórias do Instituto Oswaldo Cruz v.104 suppl.1 2009reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762009000900017info:eu-repo/semantics/openAccessGomes,Yara MLorena,Virginia MBLuquetti,Alejandro Oeng2020-04-25T17:50:36Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:16:39.179Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue |
dc.title.none.fl_str_mv |
Diagnosis of Chagas disease: what has been achieved? What remains to be done with regard to diagnosis and follow up studies? |
title |
Diagnosis of Chagas disease: what has been achieved? What remains to be done with regard to diagnosis and follow up studies? |
spellingShingle |
Diagnosis of Chagas disease: what has been achieved? What remains to be done with regard to diagnosis and follow up studies? Gomes,Yara M Chagas disease Trypanosoma cruzi etiological diagnosis |
title_short |
Diagnosis of Chagas disease: what has been achieved? What remains to be done with regard to diagnosis and follow up studies? |
title_full |
Diagnosis of Chagas disease: what has been achieved? What remains to be done with regard to diagnosis and follow up studies? |
title_fullStr |
Diagnosis of Chagas disease: what has been achieved? What remains to be done with regard to diagnosis and follow up studies? |
title_full_unstemmed |
Diagnosis of Chagas disease: what has been achieved? What remains to be done with regard to diagnosis and follow up studies? |
title_sort |
Diagnosis of Chagas disease: what has been achieved? What remains to be done with regard to diagnosis and follow up studies? |
author |
Gomes,Yara M |
author_facet |
Gomes,Yara M Lorena,Virginia MB Luquetti,Alejandro O |
author_role |
author |
author2 |
Lorena,Virginia MB Luquetti,Alejandro O |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Gomes,Yara M Lorena,Virginia MB Luquetti,Alejandro O |
dc.subject.por.fl_str_mv |
Chagas disease Trypanosoma cruzi etiological diagnosis |
topic |
Chagas disease Trypanosoma cruzi etiological diagnosis |
dc.description.none.fl_txt_mv |
In the acute phase and in the chronic forms of Chagas disease, the etiological diagnosis may be performed by detection of the parasite using direct or indirect parasitological methods and by the presence of antibodies in the serum by way of serological tests. Several techniques are easily available, ranging from the simplest wet smear preparation to immuno-enzymatic assays with recombinant antigens that will meet most diagnostic needs. Other tests under evaluation include a molecular test using polymerase chain reaction, which has shown promising results and may be used as a confirmatory test both in the acute and chronic phases of the disease. Better rapid tests are needed for diagnosis, some of which are already under evaluation. Additionally, there is a need for tools that can identify patients cured shortly after specific treatment. Other needs include a marker for prognosis and early diagnosis of congenital transmission. |
description |
In the acute phase and in the chronic forms of Chagas disease, the etiological diagnosis may be performed by detection of the parasite using direct or indirect parasitological methods and by the presence of antibodies in the serum by way of serological tests. Several techniques are easily available, ranging from the simplest wet smear preparation to immuno-enzymatic assays with recombinant antigens that will meet most diagnostic needs. Other tests under evaluation include a molecular test using polymerase chain reaction, which has shown promising results and may be used as a confirmatory test both in the acute and chronic phases of the disease. Better rapid tests are needed for diagnosis, some of which are already under evaluation. Additionally, there is a need for tools that can identify patients cured shortly after specific treatment. Other needs include a marker for prognosis and early diagnosis of congenital transmission. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-07-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000900017 |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000900017 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0074-02762009000900017 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
dc.source.none.fl_str_mv |
Memórias do Instituto Oswaldo Cruz v.104 suppl.1 2009 reponame:Memórias do Instituto Oswaldo Cruz instname:Fundação Oswaldo Cruz instacron:FIOCRUZ |
reponame_str |
Memórias do Instituto Oswaldo Cruz |
collection |
Memórias do Instituto Oswaldo Cruz |
instname_str |
Fundação Oswaldo Cruz |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
repository.name.fl_str_mv |
Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz |
repository.mail.fl_str_mv |
|
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1669937706821484544 |