Biological characterization of Trypanosoma cruzi strains

Detalhes bibliográficos
Autor(a) principal: Martínez-Díaz,Rafael A
Data de Publicação: 2001
Outros Autores: Escario,José A, Nogal-Ruiz,Juan J, Gómez-Barrio,Alicia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762001000100006
Resumo: Biological parameters of five Trypanosoma cruzi strains from different sources were determined in order to know the laboratory behaviour of natural populations. The parameters evaluated were growth kinetics of epimastigotes, differentiation into metacyclic forms, infectivity in mammalian cells grown in vitro and parasite susceptibility to nifurtimox, benznidazole and gentian violet. Differences in transformation to metacyclic, in the percentage of infected cells as well as in the number of amastigotes per cell were observed among the strains. Regarding to pharmacological assays, Y strain was the most sensitive to the three assayed compounds. These data demonstrate the heterogeneity of natural populations of T. cruzi, the only responsible of infection in humans.
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spelling Biological characterization of Trypanosoma cruzi strainsTrypanosoma cruzistrainscharacterizationBiological parameters of five Trypanosoma cruzi strains from different sources were determined in order to know the laboratory behaviour of natural populations. The parameters evaluated were growth kinetics of epimastigotes, differentiation into metacyclic forms, infectivity in mammalian cells grown in vitro and parasite susceptibility to nifurtimox, benznidazole and gentian violet. Differences in transformation to metacyclic, in the percentage of infected cells as well as in the number of amastigotes per cell were observed among the strains. Regarding to pharmacological assays, Y strain was the most sensitive to the three assayed compounds. These data demonstrate the heterogeneity of natural populations of T. cruzi, the only responsible of infection in humans.Instituto Oswaldo Cruz, Ministério da Saúde2001-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762001000100006Memórias do Instituto Oswaldo Cruz v.96 n.1 2001reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762001000100006info:eu-repo/semantics/openAccessMartínez-Díaz,Rafael AEscario,José ANogal-Ruiz,Juan JGómez-Barrio,Aliciaeng2020-04-25T17:48:30Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:10:05.961Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Biological characterization of Trypanosoma cruzi strains
title Biological characterization of Trypanosoma cruzi strains
spellingShingle Biological characterization of Trypanosoma cruzi strains
Martínez-Díaz,Rafael A
Trypanosoma cruzi
strains
characterization
title_short Biological characterization of Trypanosoma cruzi strains
title_full Biological characterization of Trypanosoma cruzi strains
title_fullStr Biological characterization of Trypanosoma cruzi strains
title_full_unstemmed Biological characterization of Trypanosoma cruzi strains
title_sort Biological characterization of Trypanosoma cruzi strains
author Martínez-Díaz,Rafael A
author_facet Martínez-Díaz,Rafael A
Escario,José A
Nogal-Ruiz,Juan J
Gómez-Barrio,Alicia
author_role author
author2 Escario,José A
Nogal-Ruiz,Juan J
Gómez-Barrio,Alicia
author2_role author
author
author
dc.contributor.author.fl_str_mv Martínez-Díaz,Rafael A
Escario,José A
Nogal-Ruiz,Juan J
Gómez-Barrio,Alicia
dc.subject.por.fl_str_mv Trypanosoma cruzi
strains
characterization
topic Trypanosoma cruzi
strains
characterization
dc.description.none.fl_txt_mv Biological parameters of five Trypanosoma cruzi strains from different sources were determined in order to know the laboratory behaviour of natural populations. The parameters evaluated were growth kinetics of epimastigotes, differentiation into metacyclic forms, infectivity in mammalian cells grown in vitro and parasite susceptibility to nifurtimox, benznidazole and gentian violet. Differences in transformation to metacyclic, in the percentage of infected cells as well as in the number of amastigotes per cell were observed among the strains. Regarding to pharmacological assays, Y strain was the most sensitive to the three assayed compounds. These data demonstrate the heterogeneity of natural populations of T. cruzi, the only responsible of infection in humans.
description Biological parameters of five Trypanosoma cruzi strains from different sources were determined in order to know the laboratory behaviour of natural populations. The parameters evaluated were growth kinetics of epimastigotes, differentiation into metacyclic forms, infectivity in mammalian cells grown in vitro and parasite susceptibility to nifurtimox, benznidazole and gentian violet. Differences in transformation to metacyclic, in the percentage of infected cells as well as in the number of amastigotes per cell were observed among the strains. Regarding to pharmacological assays, Y strain was the most sensitive to the three assayed compounds. These data demonstrate the heterogeneity of natural populations of T. cruzi, the only responsible of infection in humans.
publishDate 2001
dc.date.none.fl_str_mv 2001-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762001000100006
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762001000100006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762001000100006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.96 n.1 2001
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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