Role of a mouse monoclonal IgE antibody in passive transfer of immunity to Schistosoma japonicum infection
Autor(a) principal: | |
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Data de Publicação: | 1987 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Memórias do Instituto Oswaldo Cruz |
Texto Completo: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761987000800045 |
Resumo: | We have been able to produce a mouse monoclonal IgE antibody specific to an adult worm antigen extracted from Schistosoma japonicum (Sj). The antibody was able to elicit passive cutaneous anaphylaxis in the rat skin against Sj with the highest titer of 1:256,000 but did not cross-react with S. mansoni antigen. The antibody recognized a 97-kDa molecule expressed on the surface of mechanically transformed schistosoma of S. japonicum. Passive transfer of the antibody into mice in the early stage of challenge infection resulted in a partial but significant reduction of recovery of adult worms. Induction of eosinophilia by an oral administration of embryonated eggs of Toxocara canis prior to challenge infection enhanced the reduction. |
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Memórias do Instituto Oswaldo Cruz |
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Role of a mouse monoclonal IgE antibody in passive transfer of immunity to Schistosoma japonicum infectionWe have been able to produce a mouse monoclonal IgE antibody specific to an adult worm antigen extracted from Schistosoma japonicum (Sj). The antibody was able to elicit passive cutaneous anaphylaxis in the rat skin against Sj with the highest titer of 1:256,000 but did not cross-react with S. mansoni antigen. The antibody recognized a 97-kDa molecule expressed on the surface of mechanically transformed schistosoma of S. japonicum. Passive transfer of the antibody into mice in the early stage of challenge infection resulted in a partial but significant reduction of recovery of adult worms. Induction of eosinophilia by an oral administration of embryonated eggs of Toxocara canis prior to challenge infection enhanced the reduction.Instituto Oswaldo Cruz, Ministério da Saúde1987-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761987000800045Memórias do Instituto Oswaldo Cruz v.82 suppl.4 1987reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02761987000800045info:eu-repo/semantics/openAccessKojima,SomeiJanecharut,TuentaHata,HidekazuNiimura,Munetoshieng2020-04-25T17:46:02Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:02:13.598Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue |
dc.title.none.fl_str_mv |
Role of a mouse monoclonal IgE antibody in passive transfer of immunity to Schistosoma japonicum infection |
title |
Role of a mouse monoclonal IgE antibody in passive transfer of immunity to Schistosoma japonicum infection |
spellingShingle |
Role of a mouse monoclonal IgE antibody in passive transfer of immunity to Schistosoma japonicum infection Kojima,Somei |
title_short |
Role of a mouse monoclonal IgE antibody in passive transfer of immunity to Schistosoma japonicum infection |
title_full |
Role of a mouse monoclonal IgE antibody in passive transfer of immunity to Schistosoma japonicum infection |
title_fullStr |
Role of a mouse monoclonal IgE antibody in passive transfer of immunity to Schistosoma japonicum infection |
title_full_unstemmed |
Role of a mouse monoclonal IgE antibody in passive transfer of immunity to Schistosoma japonicum infection |
title_sort |
Role of a mouse monoclonal IgE antibody in passive transfer of immunity to Schistosoma japonicum infection |
author |
Kojima,Somei |
author_facet |
Kojima,Somei Janecharut,Tuenta Hata,Hidekazu Niimura,Munetoshi |
author_role |
author |
author2 |
Janecharut,Tuenta Hata,Hidekazu Niimura,Munetoshi |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Kojima,Somei Janecharut,Tuenta Hata,Hidekazu Niimura,Munetoshi |
dc.description.none.fl_txt_mv |
We have been able to produce a mouse monoclonal IgE antibody specific to an adult worm antigen extracted from Schistosoma japonicum (Sj). The antibody was able to elicit passive cutaneous anaphylaxis in the rat skin against Sj with the highest titer of 1:256,000 but did not cross-react with S. mansoni antigen. The antibody recognized a 97-kDa molecule expressed on the surface of mechanically transformed schistosoma of S. japonicum. Passive transfer of the antibody into mice in the early stage of challenge infection resulted in a partial but significant reduction of recovery of adult worms. Induction of eosinophilia by an oral administration of embryonated eggs of Toxocara canis prior to challenge infection enhanced the reduction. |
description |
We have been able to produce a mouse monoclonal IgE antibody specific to an adult worm antigen extracted from Schistosoma japonicum (Sj). The antibody was able to elicit passive cutaneous anaphylaxis in the rat skin against Sj with the highest titer of 1:256,000 but did not cross-react with S. mansoni antigen. The antibody recognized a 97-kDa molecule expressed on the surface of mechanically transformed schistosoma of S. japonicum. Passive transfer of the antibody into mice in the early stage of challenge infection resulted in a partial but significant reduction of recovery of adult worms. Induction of eosinophilia by an oral administration of embryonated eggs of Toxocara canis prior to challenge infection enhanced the reduction. |
publishDate |
1987 |
dc.date.none.fl_str_mv |
1987-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761987000800045 |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761987000800045 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0074-02761987000800045 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
dc.source.none.fl_str_mv |
Memórias do Instituto Oswaldo Cruz v.82 suppl.4 1987 reponame:Memórias do Instituto Oswaldo Cruz instname:Fundação Oswaldo Cruz instacron:FIOCRUZ |
reponame_str |
Memórias do Instituto Oswaldo Cruz |
collection |
Memórias do Instituto Oswaldo Cruz |
instname_str |
Fundação Oswaldo Cruz |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
repository.name.fl_str_mv |
Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz |
repository.mail.fl_str_mv |
|
_version_ |
1669937649732812800 |