Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas disease

Detalhes bibliográficos
Autor(a) principal: Macedo,Andréa M
Data de Publicação: 2004
Outros Autores: Machado,Carlos R, Oliveira,Riva P, Pena,Sérgio DJ
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Memórias do Instituto Oswaldo Cruz
Texto Completo: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000100001
Resumo: Chagas disease, caused by the protozoan Trypanosoma cruzi, has a variable clinical course, ranging from symptomless infection to severe chronic disease with cardiovascular or gastrointestinal involvement or, occasionally, overwhelming acute episodes. The factors influencing this clinical variability have not been elucidated, but it is likely that the genetic variability of both the host and the parasite are of importance. In this work we review the the genetic structure of T. cruzi populations and analyze the importance of genetic variation of the parasite in the pathogenesis of the disease under the light of the histotropic-clonal model.
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spelling Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas diseaseTrypanosoma cruzigenetic variabilitymismatch repairpopulation structurepathogenesisChagas diseaseChagas disease, caused by the protozoan Trypanosoma cruzi, has a variable clinical course, ranging from symptomless infection to severe chronic disease with cardiovascular or gastrointestinal involvement or, occasionally, overwhelming acute episodes. The factors influencing this clinical variability have not been elucidated, but it is likely that the genetic variability of both the host and the parasite are of importance. In this work we review the the genetic structure of T. cruzi populations and analyze the importance of genetic variation of the parasite in the pathogenesis of the disease under the light of the histotropic-clonal model.Instituto Oswaldo Cruz, Ministério da Saúde2004-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000100001Memórias do Instituto Oswaldo Cruz v.99 n.1 2004reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762004000100001info:eu-repo/semantics/openAccessMacedo,Andréa MMachado,Carlos ROliveira,Riva PPena,Sérgio DJeng2020-04-25T17:49:11Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:12:25.389Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue
dc.title.none.fl_str_mv Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas disease
title Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas disease
spellingShingle Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas disease
Macedo,Andréa M
Trypanosoma cruzi
genetic variability
mismatch repair
population structure
pathogenesis
Chagas disease
title_short Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas disease
title_full Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas disease
title_fullStr Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas disease
title_full_unstemmed Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas disease
title_sort Trypanosoma cruzi: genetic structure of populations and relevance of genetic variability to the pathogenesis of chagas disease
author Macedo,Andréa M
author_facet Macedo,Andréa M
Machado,Carlos R
Oliveira,Riva P
Pena,Sérgio DJ
author_role author
author2 Machado,Carlos R
Oliveira,Riva P
Pena,Sérgio DJ
author2_role author
author
author
dc.contributor.author.fl_str_mv Macedo,Andréa M
Machado,Carlos R
Oliveira,Riva P
Pena,Sérgio DJ
dc.subject.por.fl_str_mv Trypanosoma cruzi
genetic variability
mismatch repair
population structure
pathogenesis
Chagas disease
topic Trypanosoma cruzi
genetic variability
mismatch repair
population structure
pathogenesis
Chagas disease
dc.description.none.fl_txt_mv Chagas disease, caused by the protozoan Trypanosoma cruzi, has a variable clinical course, ranging from symptomless infection to severe chronic disease with cardiovascular or gastrointestinal involvement or, occasionally, overwhelming acute episodes. The factors influencing this clinical variability have not been elucidated, but it is likely that the genetic variability of both the host and the parasite are of importance. In this work we review the the genetic structure of T. cruzi populations and analyze the importance of genetic variation of the parasite in the pathogenesis of the disease under the light of the histotropic-clonal model.
description Chagas disease, caused by the protozoan Trypanosoma cruzi, has a variable clinical course, ranging from symptomless infection to severe chronic disease with cardiovascular or gastrointestinal involvement or, occasionally, overwhelming acute episodes. The factors influencing this clinical variability have not been elucidated, but it is likely that the genetic variability of both the host and the parasite are of importance. In this work we review the the genetic structure of T. cruzi populations and analyze the importance of genetic variation of the parasite in the pathogenesis of the disease under the light of the histotropic-clonal model.
publishDate 2004
dc.date.none.fl_str_mv 2004-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000100001
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000100001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0074-02762004000100001
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv Memórias do Instituto Oswaldo Cruz v.99 n.1 2004
reponame:Memórias do Instituto Oswaldo Cruz
instname:Fundação Oswaldo Cruz
instacron:FIOCRUZ
reponame_str Memórias do Instituto Oswaldo Cruz
collection Memórias do Instituto Oswaldo Cruz
instname_str Fundação Oswaldo Cruz
instacron_str FIOCRUZ
institution FIOCRUZ
repository.name.fl_str_mv Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz
repository.mail.fl_str_mv
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