Fatores de risco ambientais para o câncer gástrico: a visão do toxicologista
Autor(a) principal: | |
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Data de Publicação: | 1997 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Cadernos de Saúde Pública |
Texto Completo: | https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/962 |
Resumo: | Carcinogenesis is a highly complex process involving both inherited risk factors and environmental ones such as diet, smoking, occupation, and exposure to radiation and chemical agents. Experimental toxicology identifies potentially carcinogenic chemicals and thus makes it possible to introduce regulatory measures aimed at reducing human exposure to them. Carcinogenesis can be viewed as consisting of three distinct sequences: initiation, promotion, and progression. Neoplastic conversion (initiation) occurs when a genetic event (e.g., point mutations, chromosomal rearrangements, insertion or deletion of genes, and gene amplification) results in oncogene activation and/or lack of expression - or inactivation of products - of tumor suppressor genes. Promotion involves clonal expansion of initiated cells and requires cell proliferation. Effective strategies for reducing risk of gastric cancer or neoplasias at other sites should include both control of known carcinogens and chemical prevention through rational interventions in the carcinogenic process. The toxicologist's challenge is thus to devise better and less expensive predictive assays and to elucidate the mechanisms underlying chemical carcinogenesis. |
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Fatores de risco ambientais para o câncer gástrico: a visão do toxicologistaCarcinogênese QuímicaAmbienteTumores de EstômagoToxicologiaCarcinogenesis is a highly complex process involving both inherited risk factors and environmental ones such as diet, smoking, occupation, and exposure to radiation and chemical agents. Experimental toxicology identifies potentially carcinogenic chemicals and thus makes it possible to introduce regulatory measures aimed at reducing human exposure to them. Carcinogenesis can be viewed as consisting of three distinct sequences: initiation, promotion, and progression. Neoplastic conversion (initiation) occurs when a genetic event (e.g., point mutations, chromosomal rearrangements, insertion or deletion of genes, and gene amplification) results in oncogene activation and/or lack of expression - or inactivation of products - of tumor suppressor genes. Promotion involves clonal expansion of initiated cells and requires cell proliferation. Effective strategies for reducing risk of gastric cancer or neoplasias at other sites should include both control of known carcinogens and chemical prevention through rational interventions in the carcinogenic process. The toxicologist's challenge is thus to devise better and less expensive predictive assays and to elucidate the mechanisms underlying chemical carcinogenesis.A carcinogênese é um processo altamente complexo do qual participam fatores de risco herdados e fatores de risco ambientais, tais como a alimentação, o hábito de fumar, a ocupação, e a exposição a radiação e a agentes químicos. A toxicologia experimental identifica as substâncias químicas potencialmente carcinogênicas e torna possível medidas regulatórias que objetivam reduzir a exposição humana a elas. A carcinogênese pode ser vista como consistindo de três seqüências distintas: a iniciação, a promoção e a progressão. A conversão neoplásica (iniciação) ocorre quando um evento genético (mutações, rearranjos cromossômicos, inserções ou deleções de genes e amplificação de genes) resulta em ativação de oncogenes e/ou em falta de expressão - ou inativação de produtos - de genes supressores de tumores. A promoção envolve a expansão clonal das células "iniciadas" e exige a proliferação celular. Estratégias efetivas para reduzir os riscos de câncer gástrico e os riscos de neoplasias de outras localizações devem incluir o controle de carcinógenos conhecidos, assim como a quimioprevenção, por meio de intervenções racionais no processo carcinogênico. Neste sentido, o desafio a ser enfrentado pelo toxicologista envolve o desenvolvimento de ensaios preditivos melhores e mais baratos e a elucidação dos mecanismos subjacentes à carcinogênese química.Reports in Public HealthCadernos de Saúde Pública1997-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlapplication/pdfhttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/962Reports in Public Health; Vol. 13 No. 5 (1997): Supplement 1Cadernos de Saúde Pública; v. 13 n. 5 (1997): Suplemento 11678-44640102-311Xreponame:Cadernos de Saúde Públicainstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZporhttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/962/1914https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/962/1915Gomes-Carneiro, Maria ReginaRibeiro-Pinto, Luís FelipePaumgartten, Francisco José Romainfo:eu-repo/semantics/openAccess2024-03-06T15:26:09Zoai:ojs.teste-cadernos.ensp.fiocruz.br:article/962Revistahttps://cadernos.ensp.fiocruz.br/ojs/index.php/csphttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/oaicadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br1678-44640102-311Xopendoar:2024-03-06T13:01:10.568977Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)true |
dc.title.none.fl_str_mv |
Fatores de risco ambientais para o câncer gástrico: a visão do toxicologista |
title |
Fatores de risco ambientais para o câncer gástrico: a visão do toxicologista |
spellingShingle |
Fatores de risco ambientais para o câncer gástrico: a visão do toxicologista Gomes-Carneiro, Maria Regina Carcinogênese Química Ambiente Tumores de Estômago Toxicologia |
title_short |
Fatores de risco ambientais para o câncer gástrico: a visão do toxicologista |
title_full |
Fatores de risco ambientais para o câncer gástrico: a visão do toxicologista |
title_fullStr |
Fatores de risco ambientais para o câncer gástrico: a visão do toxicologista |
title_full_unstemmed |
Fatores de risco ambientais para o câncer gástrico: a visão do toxicologista |
title_sort |
Fatores de risco ambientais para o câncer gástrico: a visão do toxicologista |
author |
Gomes-Carneiro, Maria Regina |
author_facet |
Gomes-Carneiro, Maria Regina Ribeiro-Pinto, Luís Felipe Paumgartten, Francisco José Roma |
author_role |
author |
author2 |
Ribeiro-Pinto, Luís Felipe Paumgartten, Francisco José Roma |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Gomes-Carneiro, Maria Regina Ribeiro-Pinto, Luís Felipe Paumgartten, Francisco José Roma |
dc.subject.por.fl_str_mv |
Carcinogênese Química Ambiente Tumores de Estômago Toxicologia |
topic |
Carcinogênese Química Ambiente Tumores de Estômago Toxicologia |
description |
Carcinogenesis is a highly complex process involving both inherited risk factors and environmental ones such as diet, smoking, occupation, and exposure to radiation and chemical agents. Experimental toxicology identifies potentially carcinogenic chemicals and thus makes it possible to introduce regulatory measures aimed at reducing human exposure to them. Carcinogenesis can be viewed as consisting of three distinct sequences: initiation, promotion, and progression. Neoplastic conversion (initiation) occurs when a genetic event (e.g., point mutations, chromosomal rearrangements, insertion or deletion of genes, and gene amplification) results in oncogene activation and/or lack of expression - or inactivation of products - of tumor suppressor genes. Promotion involves clonal expansion of initiated cells and requires cell proliferation. Effective strategies for reducing risk of gastric cancer or neoplasias at other sites should include both control of known carcinogens and chemical prevention through rational interventions in the carcinogenic process. The toxicologist's challenge is thus to devise better and less expensive predictive assays and to elucidate the mechanisms underlying chemical carcinogenesis. |
publishDate |
1997 |
dc.date.none.fl_str_mv |
1997-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/962 |
url |
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/962 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/962/1914 https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/962/1915 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html application/pdf |
dc.publisher.none.fl_str_mv |
Reports in Public Health Cadernos de Saúde Pública |
publisher.none.fl_str_mv |
Reports in Public Health Cadernos de Saúde Pública |
dc.source.none.fl_str_mv |
Reports in Public Health; Vol. 13 No. 5 (1997): Supplement 1 Cadernos de Saúde Pública; v. 13 n. 5 (1997): Suplemento 1 1678-4464 0102-311X reponame:Cadernos de Saúde Pública instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
reponame_str |
Cadernos de Saúde Pública |
collection |
Cadernos de Saúde Pública |
repository.name.fl_str_mv |
Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
cadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br |
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