Vaccine development against neglected tropical diseases

Detalhes bibliográficos
Autor(a) principal: Expedito José de Albuquerque Luna
Data de Publicação: 2020
Outros Autores: Sérgio Roberto de Souza Leão da Costa Campos
Tipo de documento: Artigo
Idioma: eng
por
Título da fonte: Cadernos de Saúde Pública
Texto Completo: https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/7523
Resumo: Neglected tropical diseases constitute a heterogeneous group of diseases that have as a common characteristic to affect poor and unassisted populations with little vocalization capacity and political power. As a result, they receive little attention from the pharmaceutical industry and academia. The present study aimed to summarize the state of the art regarding vaccine development for three relevant neglected tropical diseases in Brazil: Chagas disease, schistosomiasis (Schistosoma mansoni), and leishmaniasis. To this end, we conducted a narrative review of the scientific literature, including publications that allowed us to outline a current overview on the vaccine development for the three diseases. Vaccines against the three diseases are in different stages of development. Vaccine development projects against American trypanosomiasis have yet to reach the clinical evaluation phase. For schistosomiasis, we have candidates for the vaccine in the advanced phase of clinical evaluation. For leishmaniasis, there are already licensed veterinary vaccines, and product candidates for human vaccine in the intermediate stage of clinical evaluation. The reduced funding for these projects has contributed to slow product development.
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spelling Vaccine development against neglected tropical diseasesO desenvolvimento de vacinas contra as doenças tropicais negligenciadasVaccinesNeglected DiseasesChagas DiseaseSchistosomiasis MansoniLeishmaniasisVacinasDoenças NegligenciadasDoença de ChagasEsquistossomose MansoniLeishmanioseNeglected tropical diseases constitute a heterogeneous group of diseases that have as a common characteristic to affect poor and unassisted populations with little vocalization capacity and political power. As a result, they receive little attention from the pharmaceutical industry and academia. The present study aimed to summarize the state of the art regarding vaccine development for three relevant neglected tropical diseases in Brazil: Chagas disease, schistosomiasis (Schistosoma mansoni), and leishmaniasis. To this end, we conducted a narrative review of the scientific literature, including publications that allowed us to outline a current overview on the vaccine development for the three diseases. Vaccines against the three diseases are in different stages of development. Vaccine development projects against American trypanosomiasis have yet to reach the clinical evaluation phase. For schistosomiasis, we have candidates for the vaccine in the advanced phase of clinical evaluation. For leishmaniasis, there are already licensed veterinary vaccines, and product candidates for human vaccine in the intermediate stage of clinical evaluation. The reduced funding for these projects has contributed to slow product development.Las enfermedades tropicales desatendidas constituyen un grupo heterogéneo de enfermedades, que presentan como característica común el hecho de que afectan a poblaciones pobres y desasistidas, con poca capacidad de interlocución y poder político. En consecuencia, reciben poca atención de la industria farmacéutica, así como de la academia. Este estudio tuvo como propósito resumir el estado de la cuestión, respecto al desarrollo de vacunas para tres enfermedades tropicales desatendidas relevantes en Brasil como son: la enfermedad de Chagas, la esquistosomiasis y leishmaniosis. Para ello, se realizó una revisión narrativa de la literatura científica, en la que se incluyeron publicaciones que permitieron trazar un panorama actual del desarrollo de vacunas para las tres enfermedades. Estas vacunas están en estadios distintos de desarrollo. Los proyectos de desarrollo de vacunas contra la tripanosomiasis americana todavía no llegaron a la fase clínica de evaluación. Ya en el caso de la esquistosomiasis hay candidatos a la vacuna en fase avanzada de evaluación clínica. Para las leishmaniosis ya existen vacunas veterinarias licenciadas y productos candidatos a la vacuna humana en etapa intermedia de evaluación clínica. La reducida financiación para esos proyectos ha contribuido al retraso en el desarrollo de los productos.As doenças tropicais negligenciadas constituem um grupo heterogêneo de enfermidades que apresentam como característica comum afetarem populações pobres e desassistidas, com pouca capacidade de vocalização e de poder político. Em consequência, recebem pouca atenção da indústria farmacêutica e da academia. O presente estudo teve como propósito resumir o estado da arte quanto ao desenvolvimento de vacinas para três doenças tropicais negligenciadas de relevância no Brasil, a doença de Chagas, a esquistossomose mansoni e as leishmanioses. Para tanto, realizou-se uma revisão narrativa da literatura científica, na qual foram incluídas publicações que permitiram traçar um panorama atual do desenvolvimento de vacinas para as três doenças. Essas vacinas estão em estágios distintos de desenvolvimento. Os projetos de desenvolvimento de vacinas contra a tripanossomíase americana ainda não chegaram à fase clínica de avaliação. Já para a esquistossomose há candidatos à vacina em fase avançada de avaliação clínica. Para as leishmanioses já existem vacinas veterinárias licenciadas e produtos candidatos à vacina humana em etapa intermediária de avaliação clínica. O reduzido financiamento para esses projetos tem contribuído para retardar o desenvolvimento dos produtos.Reports in Public HealthCadernos de Saúde Pública2020-11-20info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmltext/htmlapplication/pdfapplication/pdfhttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/7523Reports in Public Health; Vol. 36 No. 14 (2020): Supplement 2Cadernos de Saúde Pública; v. 36 n. 14 (2020): Suplemento 21678-44640102-311Xreponame:Cadernos de Saúde Públicainstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZengporhttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/7523/16694https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/7523/16695https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/7523/16696https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/7523/16697Expedito José de Albuquerque LunaSérgio Roberto de Souza Leão da Costa Camposinfo:eu-repo/semantics/openAccess2024-03-06T15:30:01Zoai:ojs.teste-cadernos.ensp.fiocruz.br:article/7523Revistahttps://cadernos.ensp.fiocruz.br/ojs/index.php/csphttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/oaicadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br1678-44640102-311Xopendoar:2024-03-06T13:08:39.396868Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)true
dc.title.none.fl_str_mv Vaccine development against neglected tropical diseases
O desenvolvimento de vacinas contra as doenças tropicais negligenciadas
title Vaccine development against neglected tropical diseases
spellingShingle Vaccine development against neglected tropical diseases
Expedito José de Albuquerque Luna
Vaccines
Neglected Diseases
Chagas Disease
Schistosomiasis Mansoni
Leishmaniasis
Vacinas
Doenças Negligenciadas
Doença de Chagas
Esquistossomose Mansoni
Leishmaniose
title_short Vaccine development against neglected tropical diseases
title_full Vaccine development against neglected tropical diseases
title_fullStr Vaccine development against neglected tropical diseases
title_full_unstemmed Vaccine development against neglected tropical diseases
title_sort Vaccine development against neglected tropical diseases
author Expedito José de Albuquerque Luna
author_facet Expedito José de Albuquerque Luna
Sérgio Roberto de Souza Leão da Costa Campos
author_role author
author2 Sérgio Roberto de Souza Leão da Costa Campos
author2_role author
dc.contributor.author.fl_str_mv Expedito José de Albuquerque Luna
Sérgio Roberto de Souza Leão da Costa Campos
dc.subject.por.fl_str_mv Vaccines
Neglected Diseases
Chagas Disease
Schistosomiasis Mansoni
Leishmaniasis
Vacinas
Doenças Negligenciadas
Doença de Chagas
Esquistossomose Mansoni
Leishmaniose
topic Vaccines
Neglected Diseases
Chagas Disease
Schistosomiasis Mansoni
Leishmaniasis
Vacinas
Doenças Negligenciadas
Doença de Chagas
Esquistossomose Mansoni
Leishmaniose
description Neglected tropical diseases constitute a heterogeneous group of diseases that have as a common characteristic to affect poor and unassisted populations with little vocalization capacity and political power. As a result, they receive little attention from the pharmaceutical industry and academia. The present study aimed to summarize the state of the art regarding vaccine development for three relevant neglected tropical diseases in Brazil: Chagas disease, schistosomiasis (Schistosoma mansoni), and leishmaniasis. To this end, we conducted a narrative review of the scientific literature, including publications that allowed us to outline a current overview on the vaccine development for the three diseases. Vaccines against the three diseases are in different stages of development. Vaccine development projects against American trypanosomiasis have yet to reach the clinical evaluation phase. For schistosomiasis, we have candidates for the vaccine in the advanced phase of clinical evaluation. For leishmaniasis, there are already licensed veterinary vaccines, and product candidates for human vaccine in the intermediate stage of clinical evaluation. The reduced funding for these projects has contributed to slow product development.
publishDate 2020
dc.date.none.fl_str_mv 2020-11-20
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dc.language.iso.fl_str_mv eng
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language eng
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https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/7523/16695
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/7523/16696
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dc.publisher.none.fl_str_mv Reports in Public Health
Cadernos de Saúde Pública
publisher.none.fl_str_mv Reports in Public Health
Cadernos de Saúde Pública
dc.source.none.fl_str_mv Reports in Public Health; Vol. 36 No. 14 (2020): Supplement 2
Cadernos de Saúde Pública; v. 36 n. 14 (2020): Suplemento 2
1678-4464
0102-311X
reponame:Cadernos de Saúde Pública
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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