The 2010 Meningococcal outbreak in Bahia, Brazil, was caused by 2 different STs belonging to Clonal Complex ST-103

Detalhes bibliográficos
Autor(a) principal: de Filippis, Ivano
Data de Publicação: 2012
Outros Autores: Silva, Rita de Cássia Vilasboas, de Sá, Márcia Falcão Modesto Ungar, Sardinha, Guilherme Gonçalves, Cordeiro, Soraia M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Vigilância Sanitária em Debate
Texto Completo: https://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/9
Resumo: An outbreak of meningococcal disease in the North-East (NE) region of Brazil with eleven cases and seven deaths was reported in 2009. From the eleven cases, five serogroup C meningococcal strains were isolated, four were classified as belonging to the hypervirulent clonal complex ST-103 (cc103) and one strain was not associated with any clonal complex. DNA sequencing of the genes encoding outer membrane proteins PorA and FetA showed genotype P1.5-1,10-1,36-2;F3-9 for all five strains. cc103 was first detected in the southern region of Brazil in 2007, but not associated with outbreaks. MLST analysis detected three new STs among the isolates, showing the ongoing evolution of cc103 and the need of monitoring its spread in the population.
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spelling The 2010 Meningococcal outbreak in Bahia, Brazil, was caused by 2 different STs belonging to Clonal Complex ST-103The 2010 Meningococcal outbreak in Bahia, Brazil, was caused by 2 different STs belonging to Clonal Complex ST-103Neisseria meningitidisDoença MeningocócicaClone HipervirulentoComplexo ClonalSurto de meningite menigocócicaNeisseria meningitidisMeningococcal diseaseHypervirulent cloneClonal complexMeningococcal outbreakAn outbreak of meningococcal disease in the North-East (NE) region of Brazil with eleven cases and seven deaths was reported in 2009. From the eleven cases, five serogroup C meningococcal strains were isolated, four were classified as belonging to the hypervirulent clonal complex ST-103 (cc103) and one strain was not associated with any clonal complex. DNA sequencing of the genes encoding outer membrane proteins PorA and FetA showed genotype P1.5-1,10-1,36-2;F3-9 for all five strains. cc103 was first detected in the southern region of Brazil in 2007, but not associated with outbreaks. MLST analysis detected three new STs among the isolates, showing the ongoing evolution of cc103 and the need of monitoring its spread in the population.Título em português: O surto de meningite meningocócica de 2010 na Bahia foi causado por dois ST diferentes pertencentes ao Complexo Clonal ST-103Um surto de doença meningocócica foi detectado em 2009 no estado da Bahia (NE) com onze casos confirmados e sete óbitos. A partir do material coletado dos onze casos foi possível isolar cinco cepas de meningococos do sorogrupo C, sendo quatro pertencentes ao complexo clonal hipervirulento ST-103 (cc103), enquanto que uma cepa não foi associada a nenhum complexo clonal. O sequenciamento dos genes codificantes das proteínas de membrana PorA e FetA resultou no genótipo P1.5-1,10-1,36-2;F3-9 para todas as cepas. O cc103 foi isolado pela primeira vez na região sul do Brasil em 2007, mas não de um surto. A análise por MLST detectou a presença de três novos entre os isolados, o que mostra a contínua evolução do clone cc103 e a necessidade do monitoramento de seu avanço na população susceptível.Instituto Nacional de Controle de Qualidade em Saúde2012-12-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion"Peer-reviewed article""Artículo revisado por pares""Artigo avaliado pelos pares"application/pdfhttps://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/910.3395/vd.v1n1.9Health Surveillance under Debate: Society, Science & Technology ; Vol. 1 No. 1 (2013): February; 21-24Vigilancia en Salud en Debate: Sociedad, Ciencia y Tecnología; Vol. 1 Núm. 1 (2013): Febrero; 21-24Vigil Sanit Debate, Rio de Janeiro; v. 1 n. 1 (2013): Fevereiro; 21-242317-269Xreponame:Vigilância Sanitária em Debateinstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZenghttps://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/9/10Copyright (c) 2012 Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia (Health Surveillance under Debate: Society, Science & Technology) – Visa em Debatehttps://creativecommons.org/licenses/by-nc-nd/4.0info:eu-repo/semantics/openAccessde Filippis, IvanoSilva, Rita de Cássia Vilasboasde Sá, Márcia Falcão Modesto UngarSardinha, Guilherme GonçalvesCordeiro, Soraia M.2023-06-27T14:54:35Zoai:ojs.visaemdebate.incqs.fiocruz.br:article/9Revistahttps://visaemdebate.incqs.fiocruz.br/index.php/visaemdebatePUBhttps://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/oaiincqs.visaemdebate@fiocruz.br || gisele.neves@fiocruz.br2317-269X2317-269Xopendoar:2023-06-27T14:54:35Vigilância Sanitária em Debate - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.none.fl_str_mv The 2010 Meningococcal outbreak in Bahia, Brazil, was caused by 2 different STs belonging to Clonal Complex ST-103
The 2010 Meningococcal outbreak in Bahia, Brazil, was caused by 2 different STs belonging to Clonal Complex ST-103
title The 2010 Meningococcal outbreak in Bahia, Brazil, was caused by 2 different STs belonging to Clonal Complex ST-103
spellingShingle The 2010 Meningococcal outbreak in Bahia, Brazil, was caused by 2 different STs belonging to Clonal Complex ST-103
de Filippis, Ivano
Neisseria meningitidis
Doença Meningocócica
Clone Hipervirulento
Complexo Clonal
Surto de meningite menigocócica
Neisseria meningitidis
Meningococcal disease
Hypervirulent clone
Clonal complex
Meningococcal outbreak
title_short The 2010 Meningococcal outbreak in Bahia, Brazil, was caused by 2 different STs belonging to Clonal Complex ST-103
title_full The 2010 Meningococcal outbreak in Bahia, Brazil, was caused by 2 different STs belonging to Clonal Complex ST-103
title_fullStr The 2010 Meningococcal outbreak in Bahia, Brazil, was caused by 2 different STs belonging to Clonal Complex ST-103
title_full_unstemmed The 2010 Meningococcal outbreak in Bahia, Brazil, was caused by 2 different STs belonging to Clonal Complex ST-103
title_sort The 2010 Meningococcal outbreak in Bahia, Brazil, was caused by 2 different STs belonging to Clonal Complex ST-103
author de Filippis, Ivano
author_facet de Filippis, Ivano
Silva, Rita de Cássia Vilasboas
de Sá, Márcia Falcão Modesto Ungar
Sardinha, Guilherme Gonçalves
Cordeiro, Soraia M.
author_role author
author2 Silva, Rita de Cássia Vilasboas
de Sá, Márcia Falcão Modesto Ungar
Sardinha, Guilherme Gonçalves
Cordeiro, Soraia M.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv de Filippis, Ivano
Silva, Rita de Cássia Vilasboas
de Sá, Márcia Falcão Modesto Ungar
Sardinha, Guilherme Gonçalves
Cordeiro, Soraia M.
dc.subject.por.fl_str_mv Neisseria meningitidis
Doença Meningocócica
Clone Hipervirulento
Complexo Clonal
Surto de meningite menigocócica
Neisseria meningitidis
Meningococcal disease
Hypervirulent clone
Clonal complex
Meningococcal outbreak
topic Neisseria meningitidis
Doença Meningocócica
Clone Hipervirulento
Complexo Clonal
Surto de meningite menigocócica
Neisseria meningitidis
Meningococcal disease
Hypervirulent clone
Clonal complex
Meningococcal outbreak
description An outbreak of meningococcal disease in the North-East (NE) region of Brazil with eleven cases and seven deaths was reported in 2009. From the eleven cases, five serogroup C meningococcal strains were isolated, four were classified as belonging to the hypervirulent clonal complex ST-103 (cc103) and one strain was not associated with any clonal complex. DNA sequencing of the genes encoding outer membrane proteins PorA and FetA showed genotype P1.5-1,10-1,36-2;F3-9 for all five strains. cc103 was first detected in the southern region of Brazil in 2007, but not associated with outbreaks. MLST analysis detected three new STs among the isolates, showing the ongoing evolution of cc103 and the need of monitoring its spread in the population.
publishDate 2012
dc.date.none.fl_str_mv 2012-12-13
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
"Peer-reviewed article"
"Artículo revisado por pares"
"Artigo avaliado pelos pares"
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/9
10.3395/vd.v1n1.9
url https://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/9
identifier_str_mv 10.3395/vd.v1n1.9
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://visaemdebate.incqs.fiocruz.br/index.php/visaemdebate/article/view/9/10
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Instituto Nacional de Controle de Qualidade em Saúde
publisher.none.fl_str_mv Instituto Nacional de Controle de Qualidade em Saúde
dc.source.none.fl_str_mv Health Surveillance under Debate: Society, Science & Technology ; Vol. 1 No. 1 (2013): February; 21-24
Vigilancia en Salud en Debate: Sociedad, Ciencia y Tecnología; Vol. 1 Núm. 1 (2013): Febrero; 21-24
Vigil Sanit Debate, Rio de Janeiro; v. 1 n. 1 (2013): Fevereiro; 21-24
2317-269X
reponame:Vigilância Sanitária em Debate
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Vigilância Sanitária em Debate
collection Vigilância Sanitária em Debate
repository.name.fl_str_mv Vigilância Sanitária em Debate - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv incqs.visaemdebate@fiocruz.br || gisele.neves@fiocruz.br
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