Effects of cigarette smoke on the Meckel's cartilage of rat fetus: morphologic, morphometric and stereologic study
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Dental Journal |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402005000100011 |
Resumo: | The purpose of this study was to investigate the effects of cigarette smoke on the development of the embryo mandible (Meckel's) cartilage in rat fetuses. When inhaled by female Wistar rats between the 9th and the 12th day of pregnancy, cigarette smoke (5 cigarettes a day) caused intrauterine growth retardation, providing smaller fetuses and placentas. In fetuses from the experimental group, the histopathologic examination revealed a poorly developed Meckel's cartilage with smaller chondroblasts showing a scanty cytoplasm with spherical and paler central nuclei, as well as more abundant cartilage matrix. Morphometric analysis revealed that Meckel's cartilage lacunae were smaller in the fetuses from the experimental group, although not showing any remarkable alteration in shape. The results suggested that inhalation of cigarette smoke by pregnant rats during the organogenic period induced growth retardation and delayed cellular differentiation in rat fetal Meckel's cartilage. |
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Brazilian Dental Journal |
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Effects of cigarette smoke on the Meckel's cartilage of rat fetus: morphologic, morphometric and stereologic studyMeckel's cartilagecigarette smokemorphometryrat fetusThe purpose of this study was to investigate the effects of cigarette smoke on the development of the embryo mandible (Meckel's) cartilage in rat fetuses. When inhaled by female Wistar rats between the 9th and the 12th day of pregnancy, cigarette smoke (5 cigarettes a day) caused intrauterine growth retardation, providing smaller fetuses and placentas. In fetuses from the experimental group, the histopathologic examination revealed a poorly developed Meckel's cartilage with smaller chondroblasts showing a scanty cytoplasm with spherical and paler central nuclei, as well as more abundant cartilage matrix. Morphometric analysis revealed that Meckel's cartilage lacunae were smaller in the fetuses from the experimental group, although not showing any remarkable alteration in shape. The results suggested that inhalation of cigarette smoke by pregnant rats during the organogenic period induced growth retardation and delayed cellular differentiation in rat fetal Meckel's cartilage.Fundação Odontológica de Ribeirão Preto2005-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402005000100011Brazilian Dental Journal v.16 n.1 2005reponame:Brazilian Dental Journalinstname:Fundação Odontológica de Ribeirão Preto (FUNORP)instacron:FUNORP10.1590/S0103-64402005000100011info:eu-repo/semantics/openAccessBrandini,Daniela AtiliSala,Miguel AngelLopes,Ruberval ArmandoSemprini,MarisaContrera,Mary Garcia Duarteeng2005-08-17T00:00:00Zoai:scielo:S0103-64402005000100011Revistahttps://www.scielo.br/j/bdj/https://old.scielo.br/oai/scielo-oai.phpbdj@forp.usp.br||sergio@fosjc.unesp.br1806-47600103-6440opendoar:2005-08-17T00:00Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)false |
dc.title.none.fl_str_mv |
Effects of cigarette smoke on the Meckel's cartilage of rat fetus: morphologic, morphometric and stereologic study |
title |
Effects of cigarette smoke on the Meckel's cartilage of rat fetus: morphologic, morphometric and stereologic study |
spellingShingle |
Effects of cigarette smoke on the Meckel's cartilage of rat fetus: morphologic, morphometric and stereologic study Brandini,Daniela Atili Meckel's cartilage cigarette smoke morphometry rat fetus |
title_short |
Effects of cigarette smoke on the Meckel's cartilage of rat fetus: morphologic, morphometric and stereologic study |
title_full |
Effects of cigarette smoke on the Meckel's cartilage of rat fetus: morphologic, morphometric and stereologic study |
title_fullStr |
Effects of cigarette smoke on the Meckel's cartilage of rat fetus: morphologic, morphometric and stereologic study |
title_full_unstemmed |
Effects of cigarette smoke on the Meckel's cartilage of rat fetus: morphologic, morphometric and stereologic study |
title_sort |
Effects of cigarette smoke on the Meckel's cartilage of rat fetus: morphologic, morphometric and stereologic study |
author |
Brandini,Daniela Atili |
author_facet |
Brandini,Daniela Atili Sala,Miguel Angel Lopes,Ruberval Armando Semprini,Marisa Contrera,Mary Garcia Duarte |
author_role |
author |
author2 |
Sala,Miguel Angel Lopes,Ruberval Armando Semprini,Marisa Contrera,Mary Garcia Duarte |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Brandini,Daniela Atili Sala,Miguel Angel Lopes,Ruberval Armando Semprini,Marisa Contrera,Mary Garcia Duarte |
dc.subject.por.fl_str_mv |
Meckel's cartilage cigarette smoke morphometry rat fetus |
topic |
Meckel's cartilage cigarette smoke morphometry rat fetus |
description |
The purpose of this study was to investigate the effects of cigarette smoke on the development of the embryo mandible (Meckel's) cartilage in rat fetuses. When inhaled by female Wistar rats between the 9th and the 12th day of pregnancy, cigarette smoke (5 cigarettes a day) caused intrauterine growth retardation, providing smaller fetuses and placentas. In fetuses from the experimental group, the histopathologic examination revealed a poorly developed Meckel's cartilage with smaller chondroblasts showing a scanty cytoplasm with spherical and paler central nuclei, as well as more abundant cartilage matrix. Morphometric analysis revealed that Meckel's cartilage lacunae were smaller in the fetuses from the experimental group, although not showing any remarkable alteration in shape. The results suggested that inhalation of cigarette smoke by pregnant rats during the organogenic period induced growth retardation and delayed cellular differentiation in rat fetal Meckel's cartilage. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402005000100011 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402005000100011 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-64402005000100011 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Fundação Odontológica de Ribeirão Preto |
publisher.none.fl_str_mv |
Fundação Odontológica de Ribeirão Preto |
dc.source.none.fl_str_mv |
Brazilian Dental Journal v.16 n.1 2005 reponame:Brazilian Dental Journal instname:Fundação Odontológica de Ribeirão Preto (FUNORP) instacron:FUNORP |
instname_str |
Fundação Odontológica de Ribeirão Preto (FUNORP) |
instacron_str |
FUNORP |
institution |
FUNORP |
reponame_str |
Brazilian Dental Journal |
collection |
Brazilian Dental Journal |
repository.name.fl_str_mv |
Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP) |
repository.mail.fl_str_mv |
bdj@forp.usp.br||sergio@fosjc.unesp.br |
_version_ |
1754204090054737920 |