Effects of cigarette smoke on the Meckel's cartilage of rat fetus: morphologic, morphometric and stereologic study

Detalhes bibliográficos
Autor(a) principal: Brandini,Daniela Atili
Data de Publicação: 2005
Outros Autores: Sala,Miguel Angel, Lopes,Ruberval Armando, Semprini,Marisa, Contrera,Mary Garcia Duarte
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Dental Journal
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402005000100011
Resumo: The purpose of this study was to investigate the effects of cigarette smoke on the development of the embryo mandible (Meckel's) cartilage in rat fetuses. When inhaled by female Wistar rats between the 9th and the 12th day of pregnancy, cigarette smoke (5 cigarettes a day) caused intrauterine growth retardation, providing smaller fetuses and placentas. In fetuses from the experimental group, the histopathologic examination revealed a poorly developed Meckel's cartilage with smaller chondroblasts showing a scanty cytoplasm with spherical and paler central nuclei, as well as more abundant cartilage matrix. Morphometric analysis revealed that Meckel's cartilage lacunae were smaller in the fetuses from the experimental group, although not showing any remarkable alteration in shape. The results suggested that inhalation of cigarette smoke by pregnant rats during the organogenic period induced growth retardation and delayed cellular differentiation in rat fetal Meckel's cartilage.
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spelling Effects of cigarette smoke on the Meckel's cartilage of rat fetus: morphologic, morphometric and stereologic studyMeckel's cartilagecigarette smokemorphometryrat fetusThe purpose of this study was to investigate the effects of cigarette smoke on the development of the embryo mandible (Meckel's) cartilage in rat fetuses. When inhaled by female Wistar rats between the 9th and the 12th day of pregnancy, cigarette smoke (5 cigarettes a day) caused intrauterine growth retardation, providing smaller fetuses and placentas. In fetuses from the experimental group, the histopathologic examination revealed a poorly developed Meckel's cartilage with smaller chondroblasts showing a scanty cytoplasm with spherical and paler central nuclei, as well as more abundant cartilage matrix. Morphometric analysis revealed that Meckel's cartilage lacunae were smaller in the fetuses from the experimental group, although not showing any remarkable alteration in shape. The results suggested that inhalation of cigarette smoke by pregnant rats during the organogenic period induced growth retardation and delayed cellular differentiation in rat fetal Meckel's cartilage.Fundação Odontológica de Ribeirão Preto2005-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402005000100011Brazilian Dental Journal v.16 n.1 2005reponame:Brazilian Dental Journalinstname:Fundação Odontológica de Ribeirão Preto (FUNORP)instacron:FUNORP10.1590/S0103-64402005000100011info:eu-repo/semantics/openAccessBrandini,Daniela AtiliSala,Miguel AngelLopes,Ruberval ArmandoSemprini,MarisaContrera,Mary Garcia Duarteeng2005-08-17T00:00:00Zoai:scielo:S0103-64402005000100011Revistahttps://www.scielo.br/j/bdj/https://old.scielo.br/oai/scielo-oai.phpbdj@forp.usp.br||sergio@fosjc.unesp.br1806-47600103-6440opendoar:2005-08-17T00:00Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)false
dc.title.none.fl_str_mv Effects of cigarette smoke on the Meckel's cartilage of rat fetus: morphologic, morphometric and stereologic study
title Effects of cigarette smoke on the Meckel's cartilage of rat fetus: morphologic, morphometric and stereologic study
spellingShingle Effects of cigarette smoke on the Meckel's cartilage of rat fetus: morphologic, morphometric and stereologic study
Brandini,Daniela Atili
Meckel's cartilage
cigarette smoke
morphometry
rat fetus
title_short Effects of cigarette smoke on the Meckel's cartilage of rat fetus: morphologic, morphometric and stereologic study
title_full Effects of cigarette smoke on the Meckel's cartilage of rat fetus: morphologic, morphometric and stereologic study
title_fullStr Effects of cigarette smoke on the Meckel's cartilage of rat fetus: morphologic, morphometric and stereologic study
title_full_unstemmed Effects of cigarette smoke on the Meckel's cartilage of rat fetus: morphologic, morphometric and stereologic study
title_sort Effects of cigarette smoke on the Meckel's cartilage of rat fetus: morphologic, morphometric and stereologic study
author Brandini,Daniela Atili
author_facet Brandini,Daniela Atili
Sala,Miguel Angel
Lopes,Ruberval Armando
Semprini,Marisa
Contrera,Mary Garcia Duarte
author_role author
author2 Sala,Miguel Angel
Lopes,Ruberval Armando
Semprini,Marisa
Contrera,Mary Garcia Duarte
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Brandini,Daniela Atili
Sala,Miguel Angel
Lopes,Ruberval Armando
Semprini,Marisa
Contrera,Mary Garcia Duarte
dc.subject.por.fl_str_mv Meckel's cartilage
cigarette smoke
morphometry
rat fetus
topic Meckel's cartilage
cigarette smoke
morphometry
rat fetus
description The purpose of this study was to investigate the effects of cigarette smoke on the development of the embryo mandible (Meckel's) cartilage in rat fetuses. When inhaled by female Wistar rats between the 9th and the 12th day of pregnancy, cigarette smoke (5 cigarettes a day) caused intrauterine growth retardation, providing smaller fetuses and placentas. In fetuses from the experimental group, the histopathologic examination revealed a poorly developed Meckel's cartilage with smaller chondroblasts showing a scanty cytoplasm with spherical and paler central nuclei, as well as more abundant cartilage matrix. Morphometric analysis revealed that Meckel's cartilage lacunae were smaller in the fetuses from the experimental group, although not showing any remarkable alteration in shape. The results suggested that inhalation of cigarette smoke by pregnant rats during the organogenic period induced growth retardation and delayed cellular differentiation in rat fetal Meckel's cartilage.
publishDate 2005
dc.date.none.fl_str_mv 2005-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402005000100011
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402005000100011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-64402005000100011
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Fundação Odontológica de Ribeirão Preto
publisher.none.fl_str_mv Fundação Odontológica de Ribeirão Preto
dc.source.none.fl_str_mv Brazilian Dental Journal v.16 n.1 2005
reponame:Brazilian Dental Journal
instname:Fundação Odontológica de Ribeirão Preto (FUNORP)
instacron:FUNORP
instname_str Fundação Odontológica de Ribeirão Preto (FUNORP)
instacron_str FUNORP
institution FUNORP
reponame_str Brazilian Dental Journal
collection Brazilian Dental Journal
repository.name.fl_str_mv Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)
repository.mail.fl_str_mv bdj@forp.usp.br||sergio@fosjc.unesp.br
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