Effect of sodium selenite on bone repair in tibiae of irradiated rats
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Dental Journal |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402009000300002 |
Resumo: | This study evaluated the radioprotective effect of sodium selenite on the bone repair process in tibiae of female rats. For such purpose, 100 female Wistar rats (Rattus norvegicus, albinus) were randomly assigned to 4 groups (n=25), according to the treatment received: administration of distilled water (control); administration of sodium selenite; gamma radiation; and administration of sodium selenite plus gamma radiation. A bone defect was prepared on both tibiae of all animals. Three days after surgery, the gamma radiation and selenium/gamma radiation groups received 8 Gy gamma rays on the lower limbs. Five animals per group were sacrificed 7, 14, 21, 28 days after surgery for evaluation of the repair process by bone volumetric density analysis. The 5 animals remaining in each group were sacrificed 45 days postoperatively for examination of the mature bone by scanning electron microscopy. Based on all analyzed parameters, the results of the present study suggest that sodium selenite exerted a radioprotective effect in the bone repair of tibia of irradiated rats. |
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Brazilian Dental Journal |
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Effect of sodium selenite on bone repair in tibiae of irradiated ratssodium seleniteionizing radiationradiation-protective-agentsbonefracture healingThis study evaluated the radioprotective effect of sodium selenite on the bone repair process in tibiae of female rats. For such purpose, 100 female Wistar rats (Rattus norvegicus, albinus) were randomly assigned to 4 groups (n=25), according to the treatment received: administration of distilled water (control); administration of sodium selenite; gamma radiation; and administration of sodium selenite plus gamma radiation. A bone defect was prepared on both tibiae of all animals. Three days after surgery, the gamma radiation and selenium/gamma radiation groups received 8 Gy gamma rays on the lower limbs. Five animals per group were sacrificed 7, 14, 21, 28 days after surgery for evaluation of the repair process by bone volumetric density analysis. The 5 animals remaining in each group were sacrificed 45 days postoperatively for examination of the mature bone by scanning electron microscopy. Based on all analyzed parameters, the results of the present study suggest that sodium selenite exerted a radioprotective effect in the bone repair of tibia of irradiated rats.Fundação Odontológica de Ribeirão Preto2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402009000300002Brazilian Dental Journal v.20 n.3 2009reponame:Brazilian Dental Journalinstname:Fundação Odontológica de Ribeirão Preto (FUNORP)instacron:FUNORP10.1590/S0103-64402009000300002info:eu-repo/semantics/openAccessRocha,Anna Silvia Setti daRamos-Perez,Flávia Maria de MoraesBóscolo,Frab NorbertoManzi,Flavio RicardoCchicarelo,MarilianiAlmeida,Solange Mariaeng2009-09-21T00:00:00Zoai:scielo:S0103-64402009000300002Revistahttps://www.scielo.br/j/bdj/https://old.scielo.br/oai/scielo-oai.phpbdj@forp.usp.br||sergio@fosjc.unesp.br1806-47600103-6440opendoar:2009-09-21T00:00Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)false |
dc.title.none.fl_str_mv |
Effect of sodium selenite on bone repair in tibiae of irradiated rats |
title |
Effect of sodium selenite on bone repair in tibiae of irradiated rats |
spellingShingle |
Effect of sodium selenite on bone repair in tibiae of irradiated rats Rocha,Anna Silvia Setti da sodium selenite ionizing radiation radiation-protective-agents bone fracture healing |
title_short |
Effect of sodium selenite on bone repair in tibiae of irradiated rats |
title_full |
Effect of sodium selenite on bone repair in tibiae of irradiated rats |
title_fullStr |
Effect of sodium selenite on bone repair in tibiae of irradiated rats |
title_full_unstemmed |
Effect of sodium selenite on bone repair in tibiae of irradiated rats |
title_sort |
Effect of sodium selenite on bone repair in tibiae of irradiated rats |
author |
Rocha,Anna Silvia Setti da |
author_facet |
Rocha,Anna Silvia Setti da Ramos-Perez,Flávia Maria de Moraes Bóscolo,Frab Norberto Manzi,Flavio Ricardo Cchicarelo,Mariliani Almeida,Solange Maria |
author_role |
author |
author2 |
Ramos-Perez,Flávia Maria de Moraes Bóscolo,Frab Norberto Manzi,Flavio Ricardo Cchicarelo,Mariliani Almeida,Solange Maria |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Rocha,Anna Silvia Setti da Ramos-Perez,Flávia Maria de Moraes Bóscolo,Frab Norberto Manzi,Flavio Ricardo Cchicarelo,Mariliani Almeida,Solange Maria |
dc.subject.por.fl_str_mv |
sodium selenite ionizing radiation radiation-protective-agents bone fracture healing |
topic |
sodium selenite ionizing radiation radiation-protective-agents bone fracture healing |
description |
This study evaluated the radioprotective effect of sodium selenite on the bone repair process in tibiae of female rats. For such purpose, 100 female Wistar rats (Rattus norvegicus, albinus) were randomly assigned to 4 groups (n=25), according to the treatment received: administration of distilled water (control); administration of sodium selenite; gamma radiation; and administration of sodium selenite plus gamma radiation. A bone defect was prepared on both tibiae of all animals. Three days after surgery, the gamma radiation and selenium/gamma radiation groups received 8 Gy gamma rays on the lower limbs. Five animals per group were sacrificed 7, 14, 21, 28 days after surgery for evaluation of the repair process by bone volumetric density analysis. The 5 animals remaining in each group were sacrificed 45 days postoperatively for examination of the mature bone by scanning electron microscopy. Based on all analyzed parameters, the results of the present study suggest that sodium selenite exerted a radioprotective effect in the bone repair of tibia of irradiated rats. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402009000300002 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402009000300002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-64402009000300002 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Fundação Odontológica de Ribeirão Preto |
publisher.none.fl_str_mv |
Fundação Odontológica de Ribeirão Preto |
dc.source.none.fl_str_mv |
Brazilian Dental Journal v.20 n.3 2009 reponame:Brazilian Dental Journal instname:Fundação Odontológica de Ribeirão Preto (FUNORP) instacron:FUNORP |
instname_str |
Fundação Odontológica de Ribeirão Preto (FUNORP) |
instacron_str |
FUNORP |
institution |
FUNORP |
reponame_str |
Brazilian Dental Journal |
collection |
Brazilian Dental Journal |
repository.name.fl_str_mv |
Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP) |
repository.mail.fl_str_mv |
bdj@forp.usp.br||sergio@fosjc.unesp.br |
_version_ |
1754204090973290496 |