Fish Balistes capriscus skin extract-induced relaxation in mesenteric arterial bed of rat

• Autor(a) principal: Cavalli, Lissandra Souto
• Data de Publicação: 2003
• Outros Autores: Possette, Paula Lidiane de Souza, Schmidt, Bruno Mariano da Silva, Kruel, Carla Willemann, Grando, Muriel, Furlong, Eliana Badiale, Vaz, Marta Regina Cezar, Barros, Daniela Marti, Baisch, Ana Luiza Muccillo
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da FURG (RI FURG)
• Texto Completo: http://repositorio.furg.br/handle/1/589
• topic: Nonadrenergic; Mesenteric arterial bed; Vasodilatation

The vasorelaxing activity of the aqueous extract of fish Balistes capriscus skin (AEBc) on mesenteric arterial bed (MAB) of rats was studied. The bolus injections of AEBc (bolus of 5.1, 10.2, 20.5, and 41.1 mg) significantly inhibited, in a concentration-dependent manner, the maximal contractile response induced by methoxamine (30 M) in MAB. The vasodilatation action of AEBc is not mediated through -adrenoceptors or cyclo-oxigenase, since it was not affected by propranolol (20 M) or diclofenac sodium (3 M). The vasodilator response induced by subsequent addition of AEBc Balistes capriscus in bolus was significantly reduced in water infusion for endothelium removal. Treatment with an inhibitor of NO synthase (l-NAME, 10 M) decreased AEBc effect. The guanylate cyclase inhibitor methylene blue (MB, 100 M) had no significant effect on AEBc-induced vasodilatation. These results suggest that the vasorelaxing effect of AEBc is mediated by endothelium-dependent (NO/EDRF) and endothelium-independent neurally induced vasorelaxation from nonadrenergic and noncholinergic nerves (NO).