The role of lipoic acid in the protection against of metallic pollutant effects in the shrimp Litopenaeus vannamei (Crustacea, Decapoda)
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FURG (RI FURG) |
Texto Completo: | http://repositorio.furg.br/handle/1/4320 |
Resumo: | The effects of cadmium (Cd) and arsenic (As), dosed alone or in combination have been poorly investigated in crustaceans. Besides, it is not known if dietary supplementation of exogenous antioxidants, like lipoic acid (LA), might prevent or even reverse toxic effects of Cd and As. The objective of the present study was to evaluate the role of lipoic acid in modulating biochemical responses after Cd and As exposures in Litopenaeus vannamei. Muscle from shrimp exposed to Cd alone or Cd + As showed a decrease in glutathione (GSH) levels, while the pre-treatment with LA reversed this situation. In this tissue, the pre-treatment with LA also induced an increase in glutathione-S-transferase (GST) activity in all groups. In hepatopancreas it was observed a marked accumulation of Cd and As, a decrease in the reactive oxygen species (ROS) concentration in response to Cd exposure alone (−LA); concomitant in the same group it was observed an increment of metallothionein-like content. As exposure induced an increase in GSH levels but LA reversed this increase. Also, LA showed to increase the GST activity in all groups treated. Besides, in this organ LA showed to augment total antioxidant competence. Obtained results indicate that LA can be used as a chemo-protectant against oxidative insults in shrimp. |
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The role of lipoic acid in the protection against of metallic pollutant effects in the shrimp Litopenaeus vannamei (Crustacea, Decapoda)Litopenaeus vannameiAntioxidant responsesLipoic acidArsenicCadmiumChemopreventionThe effects of cadmium (Cd) and arsenic (As), dosed alone or in combination have been poorly investigated in crustaceans. Besides, it is not known if dietary supplementation of exogenous antioxidants, like lipoic acid (LA), might prevent or even reverse toxic effects of Cd and As. The objective of the present study was to evaluate the role of lipoic acid in modulating biochemical responses after Cd and As exposures in Litopenaeus vannamei. Muscle from shrimp exposed to Cd alone or Cd + As showed a decrease in glutathione (GSH) levels, while the pre-treatment with LA reversed this situation. In this tissue, the pre-treatment with LA also induced an increase in glutathione-S-transferase (GST) activity in all groups. In hepatopancreas it was observed a marked accumulation of Cd and As, a decrease in the reactive oxygen species (ROS) concentration in response to Cd exposure alone (−LA); concomitant in the same group it was observed an increment of metallothionein-like content. As exposure induced an increase in GSH levels but LA reversed this increase. Also, LA showed to increase the GST activity in all groups treated. Besides, in this organ LA showed to augment total antioxidant competence. Obtained results indicate that LA can be used as a chemo-protectant against oxidative insults in shrimp.2014-01-23T16:34:59Z2014-01-23T16:34:59Z2013info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfLOBATO, Roberta Oliveira. Et al. The role of lipoic acid in the protection against of metallic pollutant effects in the shrimp Litopenaeus vannamei (Crustacea, Decapoda). Comparative Biochemistry and Physiology, v. 165, n. 4, p. 491-497, 2013. Disponível em: <http://ac.els-cdn.com/S1095643313000731/1-s2.0-S1095643313000731-main.pdf?_tid=3c2b3fb2-7c4f-11e3-9539-00000aacb35d&acdnat=1389616730_4a95081699520a757e36ad7ac57a826e>. Acesso em: 13 jan. 2014.1095-6433http://repositorio.furg.br/handle/1/432010.1016/j.cbpa.2013.03.015engLobato, Roberta de OliveiraNunes, Silvana ManskeWasielesky Junior, Wilson Francisco BrittoFattorini, DanieleRegoli, FrancescoMonserrat, José MaríaLima, Juliane Venturainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FURG (RI FURG)instname:Universidade Federal do Rio Grande (FURG)instacron:FURG2023-01-17T11:18:22Zoai:repositorio.furg.br:1/4320Repositório InstitucionalPUBhttps://repositorio.furg.br/oai/request || http://200.19.254.174/oai/requestopendoar:2023-01-17T11:18:22Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG)false |
dc.title.none.fl_str_mv |
The role of lipoic acid in the protection against of metallic pollutant effects in the shrimp Litopenaeus vannamei (Crustacea, Decapoda) |
title |
The role of lipoic acid in the protection against of metallic pollutant effects in the shrimp Litopenaeus vannamei (Crustacea, Decapoda) |
spellingShingle |
The role of lipoic acid in the protection against of metallic pollutant effects in the shrimp Litopenaeus vannamei (Crustacea, Decapoda) Lobato, Roberta de Oliveira Litopenaeus vannamei Antioxidant responses Lipoic acid Arsenic Cadmium Chemoprevention |
title_short |
The role of lipoic acid in the protection against of metallic pollutant effects in the shrimp Litopenaeus vannamei (Crustacea, Decapoda) |
title_full |
The role of lipoic acid in the protection against of metallic pollutant effects in the shrimp Litopenaeus vannamei (Crustacea, Decapoda) |
title_fullStr |
The role of lipoic acid in the protection against of metallic pollutant effects in the shrimp Litopenaeus vannamei (Crustacea, Decapoda) |
title_full_unstemmed |
The role of lipoic acid in the protection against of metallic pollutant effects in the shrimp Litopenaeus vannamei (Crustacea, Decapoda) |
title_sort |
The role of lipoic acid in the protection against of metallic pollutant effects in the shrimp Litopenaeus vannamei (Crustacea, Decapoda) |
author |
Lobato, Roberta de Oliveira |
author_facet |
Lobato, Roberta de Oliveira Nunes, Silvana Manske Wasielesky Junior, Wilson Francisco Britto Fattorini, Daniele Regoli, Francesco Monserrat, José María Lima, Juliane Ventura |
author_role |
author |
author2 |
Nunes, Silvana Manske Wasielesky Junior, Wilson Francisco Britto Fattorini, Daniele Regoli, Francesco Monserrat, José María Lima, Juliane Ventura |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Lobato, Roberta de Oliveira Nunes, Silvana Manske Wasielesky Junior, Wilson Francisco Britto Fattorini, Daniele Regoli, Francesco Monserrat, José María Lima, Juliane Ventura |
dc.subject.por.fl_str_mv |
Litopenaeus vannamei Antioxidant responses Lipoic acid Arsenic Cadmium Chemoprevention |
topic |
Litopenaeus vannamei Antioxidant responses Lipoic acid Arsenic Cadmium Chemoprevention |
description |
The effects of cadmium (Cd) and arsenic (As), dosed alone or in combination have been poorly investigated in crustaceans. Besides, it is not known if dietary supplementation of exogenous antioxidants, like lipoic acid (LA), might prevent or even reverse toxic effects of Cd and As. The objective of the present study was to evaluate the role of lipoic acid in modulating biochemical responses after Cd and As exposures in Litopenaeus vannamei. Muscle from shrimp exposed to Cd alone or Cd + As showed a decrease in glutathione (GSH) levels, while the pre-treatment with LA reversed this situation. In this tissue, the pre-treatment with LA also induced an increase in glutathione-S-transferase (GST) activity in all groups. In hepatopancreas it was observed a marked accumulation of Cd and As, a decrease in the reactive oxygen species (ROS) concentration in response to Cd exposure alone (−LA); concomitant in the same group it was observed an increment of metallothionein-like content. As exposure induced an increase in GSH levels but LA reversed this increase. Also, LA showed to increase the GST activity in all groups treated. Besides, in this organ LA showed to augment total antioxidant competence. Obtained results indicate that LA can be used as a chemo-protectant against oxidative insults in shrimp. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013 2014-01-23T16:34:59Z 2014-01-23T16:34:59Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
LOBATO, Roberta Oliveira. Et al. The role of lipoic acid in the protection against of metallic pollutant effects in the shrimp Litopenaeus vannamei (Crustacea, Decapoda). Comparative Biochemistry and Physiology, v. 165, n. 4, p. 491-497, 2013. Disponível em: <http://ac.els-cdn.com/S1095643313000731/1-s2.0-S1095643313000731-main.pdf?_tid=3c2b3fb2-7c4f-11e3-9539-00000aacb35d&acdnat=1389616730_4a95081699520a757e36ad7ac57a826e>. Acesso em: 13 jan. 2014. 1095-6433 http://repositorio.furg.br/handle/1/4320 10.1016/j.cbpa.2013.03.015 |
identifier_str_mv |
LOBATO, Roberta Oliveira. Et al. The role of lipoic acid in the protection against of metallic pollutant effects in the shrimp Litopenaeus vannamei (Crustacea, Decapoda). Comparative Biochemistry and Physiology, v. 165, n. 4, p. 491-497, 2013. Disponível em: <http://ac.els-cdn.com/S1095643313000731/1-s2.0-S1095643313000731-main.pdf?_tid=3c2b3fb2-7c4f-11e3-9539-00000aacb35d&acdnat=1389616730_4a95081699520a757e36ad7ac57a826e>. Acesso em: 13 jan. 2014. 1095-6433 10.1016/j.cbpa.2013.03.015 |
url |
http://repositorio.furg.br/handle/1/4320 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FURG (RI FURG) instname:Universidade Federal do Rio Grande (FURG) instacron:FURG |
instname_str |
Universidade Federal do Rio Grande (FURG) |
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FURG |
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FURG |
reponame_str |
Repositório Institucional da FURG (RI FURG) |
collection |
Repositório Institucional da FURG (RI FURG) |
repository.name.fl_str_mv |
Repositório Institucional da FURG (RI FURG) - Universidade Federal do Rio Grande (FURG) |
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