The effects of cow's milk protein allergy in children and newborns: from etiology to treatment
Autor(a) principal: | |
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Data de Publicação: | 2024 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Brazilian Journal of Implantology and Health Sciences |
Texto Completo: | https://bjihs.emnuvens.com.br/bjihs/article/view/1281 |
Resumo: | Cow's milk protein allergy (CMPA) is the most common food allergy in children under 3 years of age, involving immunological reactions against milk proteins, especially alpha-lactalbumin and casein. Cow's milk is part of "The Big-8", eight main allergens that include egg, soy, wheat, peanuts, tree nuts, fish and shellfish. The manifestations of CMPA can be: IgE-mediated, non-IgE-mediated and mixed. Those mediated by IgE antibodies are well characterized reactions. The process by which non-IgE-mediated allergy develops is not yet fully established. It includes all manifestations of hypersensitivity in which IgE antibodies do not play a role, with gastrointestinal symptoms being the main examples of this mechanism. A detailed clinical history, combined with the immediate hypersensitivity skin test (prick test) and adequate interpretation of specific serum IgE, is essential to diagnose cow's milk protein allergy (CMPA). In specific cases, the oral challenge test may be necessary. When the reaction is mediated by IgE, the prick test is usually the starting point. A negative result practically excludes IgE-mediated CMPA, while a positive result suggests the possibility but requires confirmation. CMPA treatment is based on the exclusion of cow's milk proteins from the diet, inhalation and contact with the skin must also be avoided, and the patient's nutritional needs must be maintained. For newborns and breast-fed infants, a restricted diet is recommended for the nursing mother. This work is an integrative literature review. The databases of scientific articles were used to carry out the searches: Us National Library of Medicine (PUBMED) and Scientific Electronic Library (Scielo). Therefore, this magazine's main objective is to address the causes, clinical manifestations and treatment of allergy to cow's milk protein. |
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The effects of cow's milk protein allergy in children and newborns: from etiology to treatmentLos efectos de la alergia a las proteínas de la leche de vaca en niños y recién nacidos: de la etiología al tratamientoOs efeitos da alergia a proteína do leite de vaca em crianças e recém nascido: da etiologia ao tratamento Palavras-Chave: Alergia, Leite, Vaca.Keywords: Allergy, Milk, Cow.Palabras clave: Alergia, Leche, Vaca.Cow's milk protein allergy (CMPA) is the most common food allergy in children under 3 years of age, involving immunological reactions against milk proteins, especially alpha-lactalbumin and casein. Cow's milk is part of "The Big-8", eight main allergens that include egg, soy, wheat, peanuts, tree nuts, fish and shellfish. The manifestations of CMPA can be: IgE-mediated, non-IgE-mediated and mixed. Those mediated by IgE antibodies are well characterized reactions. The process by which non-IgE-mediated allergy develops is not yet fully established. It includes all manifestations of hypersensitivity in which IgE antibodies do not play a role, with gastrointestinal symptoms being the main examples of this mechanism. A detailed clinical history, combined with the immediate hypersensitivity skin test (prick test) and adequate interpretation of specific serum IgE, is essential to diagnose cow's milk protein allergy (CMPA). In specific cases, the oral challenge test may be necessary. When the reaction is mediated by IgE, the prick test is usually the starting point. A negative result practically excludes IgE-mediated CMPA, while a positive result suggests the possibility but requires confirmation. CMPA treatment is based on the exclusion of cow's milk proteins from the diet, inhalation and contact with the skin must also be avoided, and the patient's nutritional needs must be maintained. For newborns and breast-fed infants, a restricted diet is recommended for the nursing mother. This work is an integrative literature review. The databases of scientific articles were used to carry out the searches: Us National Library of Medicine (PUBMED) and Scientific Electronic Library (Scielo). Therefore, this magazine's main objective is to address the causes, clinical manifestations and treatment of allergy to cow's milk protein.La alergia a las proteínas de la leche de vaca (APLV) es la alergia alimentaria más común en niños menores de 3 años y implica reacciones inmunológicas contra las proteínas de la leche, especialmente la alfa-lactoalbúmina y la caseína. La leche de vaca es parte de "The Big-8", ocho alérgenos principales que incluyen huevo, soja, trigo, maní, nueces, pescado y mariscos.Las manifestaciones de la APLV pueden ser: mediadas por IgE, no mediadas por IgE y mixtas. Las mediadas por anticuerpos IgE son reacciones bien caracterizadas. El proceso por el cual se desarrolla la alergia no mediada por IgE aún no está completamente establecido e incluye todas las manifestaciones de hipersensibilidad en las que los anticuerpos IgE no desempeñan ningún papel, siendo los síntomas gastrointestinales los principales ejemplos de este mecanismo.Una historia clínica detallada, combinada con la prueba cutánea de hipersensibilidad inmediata (prick test) y la interpretación adecuada de la IgE sérica específica, es esencial para diagnosticar la alergia a las proteínas de la leche de vaca (APLV). En casos concretos podrá ser necesaria la prueba de provocación oral. Cuando la reacción está mediada por IgE, la prueba de punción suele ser el punto de partida. Un resultado negativo prácticamente excluye la APLV mediada por IgE, mientras que un resultado positivo sugiere la posibilidad pero requiere confirmación.El tratamiento con APLV se basa en la exclusión de las proteínas de la leche de vaca de la dieta, también se debe evitar la inhalación y el contacto con la piel y mantener las necesidades nutricionales del paciente. Para los recién nacidos y los lactantes, se recomienda una dieta restringida para la madre lactante. Este trabajo es una revisión integradora de la literatura. Para realizar las búsquedas se utilizaron las bases de datos de artículos científicos: Biblioteca Nacional de Medicina de Estados Unidos (PUBMED) y Biblioteca Electrónica Científica (Scielo). Por ello, el principal objetivo de esta revista es abordar las causas, manifestaciones clínicas y tratamiento de la alergia a la proteína de la leche de vaca.A alergia à proteína do leite de vaca (APLV) é a alergia alimentar mais comum em crianças menores de 3 anos, envolvendo reações imunológicas contra as proteínas do leite, especialmente alfa-lactoalbumina e caseína. O leite de vaca faz parte dos "The big-8", oito principais alergênicos que incluem ovo, soja, trigo, amendoim, frutos secos, peixe e marisco. As manifestações da APLV podem ser: mediadas por IgE, não mediadas por IgE e mistas. As mediadas por anticorpos IgE são reações bem caracterizadas. O processo pelo qual a alergia não IgE mediada se desenvolve ainda não está totalmente estabelecido, inclui todas as manifestações de hipersensibilidade em que os anticorpos IgE não têm participação, sendo os sintomas gastrointestinais os principais exemplos desse mecanismo. A história clínica detalhada, combinada com o teste cutâneo de hipersensibilidade imediata (prick test) e interpretação adequada da IgE sérica específica, é fundamental para diagnosticar a alergia à proteína do leite de vaca (APLV). Em casos específicos, o teste de provocação oral pode ser necessário. Quando a reação é mediada por IgE, o prick test é geralmente o ponto de partida. Um resultado negativo praticamente exclui a APLV mediada por IgE, enquanto um positivo sugere a possibilidade, mas requer confirmação. O tratamento da APLV baseia-se na exclusão das proteínas do leite de vaca da dieta, devendo-se também evitar a inalação e o contato com a pele, e manter as necessidades nutricionais do paciente. Para os RN e lactentes em aleitamento materno, recomenda- -se a dieta de restrição para a mãe nutriz. O presente trabalho trata-se de uma revisão integrativa de literatura. Foram utilizados os bancos de dados de artigos científicos para realizar as buscas: Us National Library of Medicine (PUBMED) E Scientific Eletronic Library (Scielo). Portanto, essa revista tem como objetivo principal abordar as causas, as manifestações clinicas e o tratamento da alergia a proteína do leite de vaca. Specialized Dentistry Group2024-01-19info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://bjihs.emnuvens.com.br/bjihs/article/view/128110.36557/2674-8169.2024v6n1p1457-1468Brazilian Journal of Implantology and Health Sciences ; Vol. 6 No. 1 (2024): BJIHS QUALIS B3; 1457-1468Brazilian Journal of Implantology and Health Sciences ; Vol. 6 Núm. 1 (2024): BJIHS QUALIS B3; 1457-1468Brazilian Journal of Implantology and Health Sciences ; v. 6 n. 1 (2024): BJIHS QUALIS B3; 1457-14682674-8169reponame:Brazilian Journal of Implantology and Health Sciencesinstname:Grupo de Odontologia Especializada (GOE)instacron:GOEporhttps://bjihs.emnuvens.com.br/bjihs/article/view/1281/1466Copyright (c) 2024 Thiago Zanuto, Rebeka Vitória dos Santos Machado, Orisson De Steffani Basso, Leidiane dutra Ferreira de Azevedo, Viviane Maria de Freitas Araújo, Guilherme Oliveira de Azevedo, Rafaela da Silva Gomes, Eduardo Caetano Rodio, Flavia Fernanda Oliveira dos Santos, Nathalia Perret Gentil, Sebastian Torres, Rodrigo Daniel Zanonihttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessZanuto, ThiagoRebeka Vitória dos Santos MachadoOrisson De Steffani BassoLeidiane dutra Ferreira de AzevedoViviane Maria de Freitas AraújoGuilherme Oliveira de AzevedoRafaela da Silva GomesEduardo Caetano RodioFlavia Fernanda Oliveira dos SantosNathalia Perret GentilSebastian TorresRodrigo Daniel Zanoni2024-01-19T20:42:44Zoai:ojs.bjihs.emnuvens.com.br:article/1281Revistahttps://bjihs.emnuvens.com.br/bjihsONGhttps://bjihs.emnuvens.com.br/bjihs/oaijournal.bjihs@periodicosbrasil.com.br2674-81692674-8169opendoar:2024-01-19T20:42:44Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE)false |
dc.title.none.fl_str_mv |
The effects of cow's milk protein allergy in children and newborns: from etiology to treatment Los efectos de la alergia a las proteínas de la leche de vaca en niños y recién nacidos: de la etiología al tratamiento Os efeitos da alergia a proteína do leite de vaca em crianças e recém nascido: da etiologia ao tratamento |
title |
The effects of cow's milk protein allergy in children and newborns: from etiology to treatment |
spellingShingle |
The effects of cow's milk protein allergy in children and newborns: from etiology to treatment Zanuto, Thiago Palavras-Chave: Alergia, Leite, Vaca. Keywords: Allergy, Milk, Cow. Palabras clave: Alergia, Leche, Vaca. |
title_short |
The effects of cow's milk protein allergy in children and newborns: from etiology to treatment |
title_full |
The effects of cow's milk protein allergy in children and newborns: from etiology to treatment |
title_fullStr |
The effects of cow's milk protein allergy in children and newborns: from etiology to treatment |
title_full_unstemmed |
The effects of cow's milk protein allergy in children and newborns: from etiology to treatment |
title_sort |
The effects of cow's milk protein allergy in children and newborns: from etiology to treatment |
author |
Zanuto, Thiago |
author_facet |
Zanuto, Thiago Rebeka Vitória dos Santos Machado Orisson De Steffani Basso Leidiane dutra Ferreira de Azevedo Viviane Maria de Freitas Araújo Guilherme Oliveira de Azevedo Rafaela da Silva Gomes Eduardo Caetano Rodio Flavia Fernanda Oliveira dos Santos Nathalia Perret Gentil Sebastian Torres Rodrigo Daniel Zanoni |
author_role |
author |
author2 |
Rebeka Vitória dos Santos Machado Orisson De Steffani Basso Leidiane dutra Ferreira de Azevedo Viviane Maria de Freitas Araújo Guilherme Oliveira de Azevedo Rafaela da Silva Gomes Eduardo Caetano Rodio Flavia Fernanda Oliveira dos Santos Nathalia Perret Gentil Sebastian Torres Rodrigo Daniel Zanoni |
author2_role |
author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Zanuto, Thiago Rebeka Vitória dos Santos Machado Orisson De Steffani Basso Leidiane dutra Ferreira de Azevedo Viviane Maria de Freitas Araújo Guilherme Oliveira de Azevedo Rafaela da Silva Gomes Eduardo Caetano Rodio Flavia Fernanda Oliveira dos Santos Nathalia Perret Gentil Sebastian Torres Rodrigo Daniel Zanoni |
dc.subject.por.fl_str_mv |
Palavras-Chave: Alergia, Leite, Vaca. Keywords: Allergy, Milk, Cow. Palabras clave: Alergia, Leche, Vaca. |
topic |
Palavras-Chave: Alergia, Leite, Vaca. Keywords: Allergy, Milk, Cow. Palabras clave: Alergia, Leche, Vaca. |
description |
Cow's milk protein allergy (CMPA) is the most common food allergy in children under 3 years of age, involving immunological reactions against milk proteins, especially alpha-lactalbumin and casein. Cow's milk is part of "The Big-8", eight main allergens that include egg, soy, wheat, peanuts, tree nuts, fish and shellfish. The manifestations of CMPA can be: IgE-mediated, non-IgE-mediated and mixed. Those mediated by IgE antibodies are well characterized reactions. The process by which non-IgE-mediated allergy develops is not yet fully established. It includes all manifestations of hypersensitivity in which IgE antibodies do not play a role, with gastrointestinal symptoms being the main examples of this mechanism. A detailed clinical history, combined with the immediate hypersensitivity skin test (prick test) and adequate interpretation of specific serum IgE, is essential to diagnose cow's milk protein allergy (CMPA). In specific cases, the oral challenge test may be necessary. When the reaction is mediated by IgE, the prick test is usually the starting point. A negative result practically excludes IgE-mediated CMPA, while a positive result suggests the possibility but requires confirmation. CMPA treatment is based on the exclusion of cow's milk proteins from the diet, inhalation and contact with the skin must also be avoided, and the patient's nutritional needs must be maintained. For newborns and breast-fed infants, a restricted diet is recommended for the nursing mother. This work is an integrative literature review. The databases of scientific articles were used to carry out the searches: Us National Library of Medicine (PUBMED) and Scientific Electronic Library (Scielo). Therefore, this magazine's main objective is to address the causes, clinical manifestations and treatment of allergy to cow's milk protein. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-01-19 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/1281 10.36557/2674-8169.2024v6n1p1457-1468 |
url |
https://bjihs.emnuvens.com.br/bjihs/article/view/1281 |
identifier_str_mv |
10.36557/2674-8169.2024v6n1p1457-1468 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://bjihs.emnuvens.com.br/bjihs/article/view/1281/1466 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Specialized Dentistry Group |
publisher.none.fl_str_mv |
Specialized Dentistry Group |
dc.source.none.fl_str_mv |
Brazilian Journal of Implantology and Health Sciences ; Vol. 6 No. 1 (2024): BJIHS QUALIS B3; 1457-1468 Brazilian Journal of Implantology and Health Sciences ; Vol. 6 Núm. 1 (2024): BJIHS QUALIS B3; 1457-1468 Brazilian Journal of Implantology and Health Sciences ; v. 6 n. 1 (2024): BJIHS QUALIS B3; 1457-1468 2674-8169 reponame:Brazilian Journal of Implantology and Health Sciences instname:Grupo de Odontologia Especializada (GOE) instacron:GOE |
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Grupo de Odontologia Especializada (GOE) |
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GOE |
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GOE |
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Brazilian Journal of Implantology and Health Sciences |
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Brazilian Journal of Implantology and Health Sciences |
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Brazilian Journal of Implantology and Health Sciences - Grupo de Odontologia Especializada (GOE) |
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journal.bjihs@periodicosbrasil.com.br |
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