Enhancement of sodium intestinal secretion in relation to absorption in malnourished rats: hyperosmolar challenge

• Autor(a) principal: ANGELIS,Rebeca C de
• Data de Publicação: 1999
• Outros Autores: CAMPOS,José Vicente Martins, ROGANO,Regina N., GIULI,Geza G., TERRA,Ilza C. M., SCIALFA,Julieta H., KLEMPS-FILHO,Itamar
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Arquivos de gastroenterologia (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28031999000400010
• topic: Intestinal secretions; Nutrition disorders; Sodium; Intestinal absorption; Rats

Two experimental models were tried in young malnourished rats in order to study effect of an hyperosmolar challenge in the small intestine on the bi-directional fluxes of sodium. Weanling rats were fed with energy restricted diets. In model I 1 mL of NaCl 900 mOsm/kg was introduced in the small intestine of the rats and left from 5 up to 70 min, in order to determine the moment of higher net Na+ secretion, which occurred at 10 min. In model II, the bi-directional fluxes of Na+ and Cl- were studied using NaCl or mannitol 900 mOsm/kg under the effect of mecholil, atropine or 2-4 dinitrophenol, for 10 min. Mecholil decreased the Na+ absorption enhancing the net secretion. Control rats were used as reference. In the restricted diets animals occurred an increase of the net secretion stimulated by NaCl 900 mOsm/kg, and this effect was enhanced by mecholil. It is suggested that in malnutrition there is an impairment in Na- intestinal absorption.