Towards therapeutic alternatives for mercury neurotoxicity in the amazon: unraveling the pre-clinical effects of the superfruit açaí (euterpe oleracea, mart.) as juice for human consumption
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/3976 |
Resumo: | Methylmercury (MeHg) exposure is a serious problem of public health, especially in the Amazon. Exposure in riverine populations is responsible for neurobehavioral abnormalities. It was hypothesized that consumption of Amazonian fruits could protect by reducing mercury accumulation. This work analyzed the effects of commercial samples of Euterpe oleracea (EO) for human consumption (10 μL/g) against MeHg i.p. exposure (2.5 mg/Kg), using neurobehavioral (open field, rotarod and pole tests), biochemical (lipid peroxidation and nitrite levels), aging-related (telomerase reverse transcriptase (TERT) mRNA expression) and toxicokinetic (MeHg content) parameters in mice. Both the pole and rotarod tests were the most sensitive tests accompanied by increased lipid peroxidation and nitrite levels in brains. MeHg reduced TERT mRNA about 50% demonstrating a strong pro-aging effect. The EO intake, similar to that of human populations, prevented all alterations, without changing the mercury content, but avoiding neurotoxicity and premature aging of the Central Nervous System (CNS). Contrary to the hypothesis found in the literature on the possible chelating properties of Amazonian fruits consumption, the effect of EO would be essentially pharmacodynamics, and possible mechanisms are discussed. Our data already support the regular consumption of EO as an excellent option for exposed Amazonian populations to have additional protection against MeHg intoxication |
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Crespo-López, Maria ElenaSoares, Ericks SousaMacchi, Barbarella de MatosSantos-Sacramento, LeticiaTakeda, Priscila YukiLopes-Araújo, AmandaParaense, Ricardo Sousa de OliveiraSouza-Monteiro, José RogérioOliveira, Marcus Augusto deLuz, Diandra AraújoMaia, Cristiane do Socorro FerrazRogez, HervéLima, Marcelo de OliveiraPereira, João PauloOliveira, Diomar CavalcanteBurbano, Rommel RodriguesLima, Rafael RodriguesNascimento, José Luiz Martins doArrifano, Gabriela de Paula2019-11-18T17:07:57Z2019-11-18T17:07:57Z2019CRESPO-LÓPEZ, Maria Elena et al. Towards therapeutic alternatives for mercury neurotoxicity in the amazon: unraveling the pre-clinical effects of the superfruit açaí (euterpe oleracea, mart.) as juice for human consumption. Nutrients, v. 11, n. 11, p. 1-19, 2019.2072-6643https://patua.iec.gov.br/handle/iec/397610.3390/nu11112585Methylmercury (MeHg) exposure is a serious problem of public health, especially in the Amazon. Exposure in riverine populations is responsible for neurobehavioral abnormalities. It was hypothesized that consumption of Amazonian fruits could protect by reducing mercury accumulation. This work analyzed the effects of commercial samples of Euterpe oleracea (EO) for human consumption (10 μL/g) against MeHg i.p. exposure (2.5 mg/Kg), using neurobehavioral (open field, rotarod and pole tests), biochemical (lipid peroxidation and nitrite levels), aging-related (telomerase reverse transcriptase (TERT) mRNA expression) and toxicokinetic (MeHg content) parameters in mice. Both the pole and rotarod tests were the most sensitive tests accompanied by increased lipid peroxidation and nitrite levels in brains. MeHg reduced TERT mRNA about 50% demonstrating a strong pro-aging effect. The EO intake, similar to that of human populations, prevented all alterations, without changing the mercury content, but avoiding neurotoxicity and premature aging of the Central Nervous System (CNS). Contrary to the hypothesis found in the literature on the possible chelating properties of Amazonian fruits consumption, the effect of EO would be essentially pharmacodynamics, and possible mechanisms are discussed. Our data already support the regular consumption of EO as an excellent option for exposed Amazonian populations to have additional protection against MeHg intoxicationConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, grant numbers 27724/2018-2 and 307564/2017-7), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, grant numbers 88887.200500/2018-00 and 88881.172137/2018-01), and Pró-reitoria de Pesquisa da Universidade Federal do Pará (PROPESP—UFPA, s/n)Federal University of Pará. Laboratory of Molecular Pharmacology. Belém, PA, Brazil.Federal University of Pará. Laboratory of Molecular Pharmacology. Belém, PA, Brazil / Federal University of Santa Catarina. Center of Biological Sciences. Laboratory of Neurochemical Investigation. Florianópolis, SC, Brazil.Federal University of Pará. Laboratory of Molecular and Cellular Neurochemistry. Belém, PA, Brazil.Federal University of Pará. Laboratory of Molecular Pharmacology. Belém, PA, Brazil.Federal University of Pará. Laboratory of Molecular Pharmacology. Belém, PA, Brazil.Federal University of Pará. Laboratory of Molecular Pharmacology. Belém, PA, Brazil.Federal University of Pará. Laboratory of Molecular Pharmacology. Belém, PA, Brazil.Federal University of Pará. Laboratory of Molecular Pharmacology. Belém, PA, Brazil.Federal University of Pará. Laboratory of Molecular Pharmacology. Belém, PA, Brazil / University of Oxford. Department of Pharmacology. Laboratory of Experimental Neuropathology. Oxford, OX. UK.Federal University of Pará. Laboratory of Pharmacology of Inflammation and Behavior. Belém, PA, Brazil.Federal University of Pará. Laboratory of Pharmacology of Inflammation and Behavior. Belém, PA, Brazil.Federal University of Pará. Centre for Valorisation of Amazonian Bioactive Compounds. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ophir Loyola Hospital. Laboratory of Molecular Biology. Belém, PA, Brazil.Federal University of Pará. Laboratory of Functional and Structural Biology. Belém, PA, Brazil.Federal University of Pará. Laboratory of Molecular and Cellular Neurochemistry. Belém, PA, BrazilFederal University of Pará. Laboratory of Molecular Pharmacology. Belém, PA, Brazil / University of Oxford. Department of Pharmacology. Laboratory of Experimental Neuropathology. 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dc.title.pt_BR.fl_str_mv |
Towards therapeutic alternatives for mercury neurotoxicity in the amazon: unraveling the pre-clinical effects of the superfruit açaí (euterpe oleracea, mart.) as juice for human consumption |
title |
Towards therapeutic alternatives for mercury neurotoxicity in the amazon: unraveling the pre-clinical effects of the superfruit açaí (euterpe oleracea, mart.) as juice for human consumption |
spellingShingle |
Towards therapeutic alternatives for mercury neurotoxicity in the amazon: unraveling the pre-clinical effects of the superfruit açaí (euterpe oleracea, mart.) as juice for human consumption Crespo-López, Maria Elena Euterpe / metabolismo Euterpe / efeitos dos fármacos Ingestão de Alimentos Sucos de Frutas e Vegetais Antioxidantes Sistema Nervoso Central / efeitos dos fármacos Intoxicação do Sistema Nervoso por Mercúrio Compostos de Metilmercúrio / toxicidade Envelhecimento / metabolismo |
title_short |
Towards therapeutic alternatives for mercury neurotoxicity in the amazon: unraveling the pre-clinical effects of the superfruit açaí (euterpe oleracea, mart.) as juice for human consumption |
title_full |
Towards therapeutic alternatives for mercury neurotoxicity in the amazon: unraveling the pre-clinical effects of the superfruit açaí (euterpe oleracea, mart.) as juice for human consumption |
title_fullStr |
Towards therapeutic alternatives for mercury neurotoxicity in the amazon: unraveling the pre-clinical effects of the superfruit açaí (euterpe oleracea, mart.) as juice for human consumption |
title_full_unstemmed |
Towards therapeutic alternatives for mercury neurotoxicity in the amazon: unraveling the pre-clinical effects of the superfruit açaí (euterpe oleracea, mart.) as juice for human consumption |
title_sort |
Towards therapeutic alternatives for mercury neurotoxicity in the amazon: unraveling the pre-clinical effects of the superfruit açaí (euterpe oleracea, mart.) as juice for human consumption |
author |
Crespo-López, Maria Elena |
author_facet |
Crespo-López, Maria Elena Soares, Ericks Sousa Macchi, Barbarella de Matos Santos-Sacramento, Leticia Takeda, Priscila Yuki Lopes-Araújo, Amanda Paraense, Ricardo Sousa de Oliveira Souza-Monteiro, José Rogério Oliveira, Marcus Augusto de Luz, Diandra Araújo Maia, Cristiane do Socorro Ferraz Rogez, Hervé Lima, Marcelo de Oliveira Pereira, João Paulo Oliveira, Diomar Cavalcante Burbano, Rommel Rodrigues Lima, Rafael Rodrigues Nascimento, José Luiz Martins do Arrifano, Gabriela de Paula |
author_role |
author |
author2 |
Soares, Ericks Sousa Macchi, Barbarella de Matos Santos-Sacramento, Leticia Takeda, Priscila Yuki Lopes-Araújo, Amanda Paraense, Ricardo Sousa de Oliveira Souza-Monteiro, José Rogério Oliveira, Marcus Augusto de Luz, Diandra Araújo Maia, Cristiane do Socorro Ferraz Rogez, Hervé Lima, Marcelo de Oliveira Pereira, João Paulo Oliveira, Diomar Cavalcante Burbano, Rommel Rodrigues Lima, Rafael Rodrigues Nascimento, José Luiz Martins do Arrifano, Gabriela de Paula |
author2_role |
author author author author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Crespo-López, Maria Elena Soares, Ericks Sousa Macchi, Barbarella de Matos Santos-Sacramento, Leticia Takeda, Priscila Yuki Lopes-Araújo, Amanda Paraense, Ricardo Sousa de Oliveira Souza-Monteiro, José Rogério Oliveira, Marcus Augusto de Luz, Diandra Araújo Maia, Cristiane do Socorro Ferraz Rogez, Hervé Lima, Marcelo de Oliveira Pereira, João Paulo Oliveira, Diomar Cavalcante Burbano, Rommel Rodrigues Lima, Rafael Rodrigues Nascimento, José Luiz Martins do Arrifano, Gabriela de Paula |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Euterpe / metabolismo Euterpe / efeitos dos fármacos Ingestão de Alimentos Sucos de Frutas e Vegetais Antioxidantes Sistema Nervoso Central / efeitos dos fármacos Intoxicação do Sistema Nervoso por Mercúrio Compostos de Metilmercúrio / toxicidade Envelhecimento / metabolismo |
topic |
Euterpe / metabolismo Euterpe / efeitos dos fármacos Ingestão de Alimentos Sucos de Frutas e Vegetais Antioxidantes Sistema Nervoso Central / efeitos dos fármacos Intoxicação do Sistema Nervoso por Mercúrio Compostos de Metilmercúrio / toxicidade Envelhecimento / metabolismo |
description |
Methylmercury (MeHg) exposure is a serious problem of public health, especially in the Amazon. Exposure in riverine populations is responsible for neurobehavioral abnormalities. It was hypothesized that consumption of Amazonian fruits could protect by reducing mercury accumulation. This work analyzed the effects of commercial samples of Euterpe oleracea (EO) for human consumption (10 μL/g) against MeHg i.p. exposure (2.5 mg/Kg), using neurobehavioral (open field, rotarod and pole tests), biochemical (lipid peroxidation and nitrite levels), aging-related (telomerase reverse transcriptase (TERT) mRNA expression) and toxicokinetic (MeHg content) parameters in mice. Both the pole and rotarod tests were the most sensitive tests accompanied by increased lipid peroxidation and nitrite levels in brains. MeHg reduced TERT mRNA about 50% demonstrating a strong pro-aging effect. The EO intake, similar to that of human populations, prevented all alterations, without changing the mercury content, but avoiding neurotoxicity and premature aging of the Central Nervous System (CNS). Contrary to the hypothesis found in the literature on the possible chelating properties of Amazonian fruits consumption, the effect of EO would be essentially pharmacodynamics, and possible mechanisms are discussed. Our data already support the regular consumption of EO as an excellent option for exposed Amazonian populations to have additional protection against MeHg intoxication |
publishDate |
2019 |
dc.date.accessioned.fl_str_mv |
2019-11-18T17:07:57Z |
dc.date.available.fl_str_mv |
2019-11-18T17:07:57Z |
dc.date.issued.fl_str_mv |
2019 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
CRESPO-LÓPEZ, Maria Elena et al. Towards therapeutic alternatives for mercury neurotoxicity in the amazon: unraveling the pre-clinical effects of the superfruit açaí (euterpe oleracea, mart.) as juice for human consumption. Nutrients, v. 11, n. 11, p. 1-19, 2019. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/3976 |
dc.identifier.issn.-.fl_str_mv |
2072-6643 |
dc.identifier.doi.-.fl_str_mv |
10.3390/nu11112585 |
identifier_str_mv |
CRESPO-LÓPEZ, Maria Elena et al. Towards therapeutic alternatives for mercury neurotoxicity in the amazon: unraveling the pre-clinical effects of the superfruit açaí (euterpe oleracea, mart.) as juice for human consumption. Nutrients, v. 11, n. 11, p. 1-19, 2019. 2072-6643 10.3390/nu11112585 |
url |
https://patua.iec.gov.br/handle/iec/3976 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
MDPI |
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MDPI |
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