Epidemiology of the Epstein–Barr Virus in autoimmune inflammatory rheumatic diseases in Northern Brazil
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/4515 |
Resumo: | The present study aimed to describe the seroprevalence infection, Epstein-Barr virus (EBV) genotypes, relate the infection's profile with the epidemiological and corticotherapy data of patients with Autoimmune inflammatory rheumatic diseases (AIRD). A cross-sectional study was carried out with 139 individuals, 92 with systemic lupus erythematosus (SLE), 27 with rheumatoid arthritis (RA) and 20 with other autoimmune diseases, who were undergoing clinical follow-up in Brazil. Serological tests for the detection of EBV anti-VCA IgM and IgG antibodies, as well as the amplification of a segment of the EBV EBNA-3c gene by conventional PCR were performed to identify the infection and the viral subtype. The Epstein-Barr nuclear antigen 3 (EBNA3C) gene participates of maintenance of viral latency and infected B-lymphocytes immortalization by unclear signaling cascades. The association of active/latent EBV infection with EBV infection profile was assessed by Fisher's exact test and multiple logistic regression. The seroprevalence of EBV anti-VCA IgG was 100%, while that of anti-VCA IgM was 1.43% (2/139). Active-phase infection was confirmed by the presence of EBV DNA in 40.29% of the population evaluated (56/139), with 45.65% (42/92) in SLE, 25.92% (7/27) in the RA and in 35% (7/20) in other autoimmune diseases. It was observed that individuals with SLE had a higher prevalence of active/lytic EBV infection and that oral corticosteroid therapy at a dose lower than 20 mg/day increased the risk of EBV activity by up to 11 times. Only the presence of EBV-1 was identified. Thus, EBV lytic infection was higher in individuals with SLE when compared to other autoimmune diseases with rheumatologic involvement and the lytic activity of the virus precedes corticosteroid-induced immunosuppression. |
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França, Samires Avelino de SouzaViana, Julimar Benedita Gomes de OliveiraGóes, Hilda Carla AzevedoFonseca, Ricardo Roberto de SouzaLaurentino, Rogério ValoisCosta, Igor BrasilOliveira Filho, Aldemir Branco deMachado, Luiz Fernando Almeida2022-05-20T13:55:35Z2022-05-20T13:55:35Z2022FRANÇA, Samires Avelino de Souza et al. Epidemiology of the Epstein–Barr Virus in autoimmune inflammatory rheumatic diseases in Northern Brazil. Viruses, v. 14, n. 4, p. 1-20, Mar. 2022.1999-4915https://patua.iec.gov.br/handle/iec/451510.3390/v14040694.The present study aimed to describe the seroprevalence infection, Epstein-Barr virus (EBV) genotypes, relate the infection's profile with the epidemiological and corticotherapy data of patients with Autoimmune inflammatory rheumatic diseases (AIRD). A cross-sectional study was carried out with 139 individuals, 92 with systemic lupus erythematosus (SLE), 27 with rheumatoid arthritis (RA) and 20 with other autoimmune diseases, who were undergoing clinical follow-up in Brazil. Serological tests for the detection of EBV anti-VCA IgM and IgG antibodies, as well as the amplification of a segment of the EBV EBNA-3c gene by conventional PCR were performed to identify the infection and the viral subtype. The Epstein-Barr nuclear antigen 3 (EBNA3C) gene participates of maintenance of viral latency and infected B-lymphocytes immortalization by unclear signaling cascades. The association of active/latent EBV infection with EBV infection profile was assessed by Fisher's exact test and multiple logistic regression. The seroprevalence of EBV anti-VCA IgG was 100%, while that of anti-VCA IgM was 1.43% (2/139). Active-phase infection was confirmed by the presence of EBV DNA in 40.29% of the population evaluated (56/139), with 45.65% (42/92) in SLE, 25.92% (7/27) in the RA and in 35% (7/20) in other autoimmune diseases. It was observed that individuals with SLE had a higher prevalence of active/lytic EBV infection and that oral corticosteroid therapy at a dose lower than 20 mg/day increased the risk of EBV activity by up to 11 times. Only the presence of EBV-1 was identified. Thus, EBV lytic infection was higher in individuals with SLE when compared to other autoimmune diseases with rheumatologic involvement and the lytic activity of the virus precedes corticosteroid-induced immunosuppression.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Ministry of Education—Brazil—Grant code 001 and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). CNPq Grantee (#314209/2021-2). Public Notice PAPQ, PROPESP/FADESP of the Federal University of Pará.Federal University of Pará. Biology of Infectious and Parasitic Agents Post-Graduate Program. Belém, PA, Brazil / Federal University of Pará. Institute of Biological Sciences. Virology Laboratory. Belém , PA, BrazilFederal University of Pará. Institute of Biological Sciences. Virology Laboratory. Belém, PA, BrazilFederal University of Pará. Biology of Infectious and Parasitic Agents Post-Graduate Program. Belém, PA, Brazil / Federal University of Pará. Institute of Biological Sciences. Virology Laboratory. Belém , PA, BrazilFederal University of Pará. Biology of Infectious and Parasitic Agents Post-Graduate Program. Belém, PA, Brazil / Federal University of Pará. Institute of Biological Sciences. Virology Laboratory. Belém , PA, BrazilFederal University of Pará. Institute of Biological Sciences. Virology Laboratory. Belém , PA, BrazilMinistério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, BrasilFederal University of Pará. Institute for Coastal Studies. Study and Research Group on Vulnerable Populations. Bragança, PA, BrazilFederal University of Pará. Biology of Infectious and Parasitic Agents Post-Graduate Program. Belém, PA, Brazil / Federal University of Pará. Institute of Biological Sciences. Virology Laboratory. Belém , PA, BrazilengMDPIEpidemiology of the Epstein–Barr Virus in autoimmune inflammatory rheumatic diseases in Northern Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInfecções por Vírus Epstein-Barr / patologiaDoenças AutoimunesDoenças Reumáticas / patologiaArtrite ReumatoideLúpus Eritematoso Sistêmicoinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALEpidemiology of the Epstein–Barr Virus in autoimmune inflammatory rheumatic diseases in Northern Brazil.pdfEpidemiology of the Epstein–Barr Virus in autoimmune inflammatory rheumatic diseases in Northern Brazil.pdfapplication/pdf280946https://patua.iec.gov.br/bitstreams/6268ffb6-18c9-4027-95fd-4002580aeb5b/download8fa20ddffa6a91aaf978035231ac8ec6MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/6713d415-a43e-4d8b-9798-8ed924e9f727/download11832eea31b16df8613079d742d61793MD52TEXTEpidemiology of the Epstein–Barr Virus in autoimmune inflammatory rheumatic diseases in Northern Brazil.pdf.txtEpidemiology of the Epstein–Barr Virus in autoimmune inflammatory rheumatic diseases in Northern Brazil.pdf.txtExtracted texttext/plain41505https://patua.iec.gov.br/bitstreams/b3b1c8f3-fd3e-4fd1-a4a9-99e2cc5e02f9/download29fc574193641c87afd579cd0b67ff7aMD55THUMBNAILEpidemiology of the Epstein–Barr Virus in autoimmune inflammatory rheumatic diseases in Northern Brazil.pdf.jpgEpidemiology of the Epstein–Barr Virus in autoimmune inflammatory rheumatic diseases in Northern Brazil.pdf.jpgGenerated Thumbnailimage/jpeg5825https://patua.iec.gov.br/bitstreams/5d2f85ce-81d0-4f50-8a97-8a37ee52c8e6/download8a220b5eeaa2bb1b5174ba7e9977680cMD56iec/45152022-10-20 21:06:55.529oai:patua.iec.gov.br:iec/4515https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T21:06:55Repositório Digital do Instituto Evandro Chagas (Patuá) - 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dc.title.pt_BR.fl_str_mv |
Epidemiology of the Epstein–Barr Virus in autoimmune inflammatory rheumatic diseases in Northern Brazil |
title |
Epidemiology of the Epstein–Barr Virus in autoimmune inflammatory rheumatic diseases in Northern Brazil |
spellingShingle |
Epidemiology of the Epstein–Barr Virus in autoimmune inflammatory rheumatic diseases in Northern Brazil França, Samires Avelino de Souza Infecções por Vírus Epstein-Barr / patologia Doenças Autoimunes Doenças Reumáticas / patologia Artrite Reumatoide Lúpus Eritematoso Sistêmico |
title_short |
Epidemiology of the Epstein–Barr Virus in autoimmune inflammatory rheumatic diseases in Northern Brazil |
title_full |
Epidemiology of the Epstein–Barr Virus in autoimmune inflammatory rheumatic diseases in Northern Brazil |
title_fullStr |
Epidemiology of the Epstein–Barr Virus in autoimmune inflammatory rheumatic diseases in Northern Brazil |
title_full_unstemmed |
Epidemiology of the Epstein–Barr Virus in autoimmune inflammatory rheumatic diseases in Northern Brazil |
title_sort |
Epidemiology of the Epstein–Barr Virus in autoimmune inflammatory rheumatic diseases in Northern Brazil |
author |
França, Samires Avelino de Souza |
author_facet |
França, Samires Avelino de Souza Viana, Julimar Benedita Gomes de Oliveira Góes, Hilda Carla Azevedo Fonseca, Ricardo Roberto de Souza Laurentino, Rogério Valois Costa, Igor Brasil Oliveira Filho, Aldemir Branco de Machado, Luiz Fernando Almeida |
author_role |
author |
author2 |
Viana, Julimar Benedita Gomes de Oliveira Góes, Hilda Carla Azevedo Fonseca, Ricardo Roberto de Souza Laurentino, Rogério Valois Costa, Igor Brasil Oliveira Filho, Aldemir Branco de Machado, Luiz Fernando Almeida |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
França, Samires Avelino de Souza Viana, Julimar Benedita Gomes de Oliveira Góes, Hilda Carla Azevedo Fonseca, Ricardo Roberto de Souza Laurentino, Rogério Valois Costa, Igor Brasil Oliveira Filho, Aldemir Branco de Machado, Luiz Fernando Almeida |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Infecções por Vírus Epstein-Barr / patologia Doenças Autoimunes Doenças Reumáticas / patologia Artrite Reumatoide Lúpus Eritematoso Sistêmico |
topic |
Infecções por Vírus Epstein-Barr / patologia Doenças Autoimunes Doenças Reumáticas / patologia Artrite Reumatoide Lúpus Eritematoso Sistêmico |
description |
The present study aimed to describe the seroprevalence infection, Epstein-Barr virus (EBV) genotypes, relate the infection's profile with the epidemiological and corticotherapy data of patients with Autoimmune inflammatory rheumatic diseases (AIRD). A cross-sectional study was carried out with 139 individuals, 92 with systemic lupus erythematosus (SLE), 27 with rheumatoid arthritis (RA) and 20 with other autoimmune diseases, who were undergoing clinical follow-up in Brazil. Serological tests for the detection of EBV anti-VCA IgM and IgG antibodies, as well as the amplification of a segment of the EBV EBNA-3c gene by conventional PCR were performed to identify the infection and the viral subtype. The Epstein-Barr nuclear antigen 3 (EBNA3C) gene participates of maintenance of viral latency and infected B-lymphocytes immortalization by unclear signaling cascades. The association of active/latent EBV infection with EBV infection profile was assessed by Fisher's exact test and multiple logistic regression. The seroprevalence of EBV anti-VCA IgG was 100%, while that of anti-VCA IgM was 1.43% (2/139). Active-phase infection was confirmed by the presence of EBV DNA in 40.29% of the population evaluated (56/139), with 45.65% (42/92) in SLE, 25.92% (7/27) in the RA and in 35% (7/20) in other autoimmune diseases. It was observed that individuals with SLE had a higher prevalence of active/lytic EBV infection and that oral corticosteroid therapy at a dose lower than 20 mg/day increased the risk of EBV activity by up to 11 times. Only the presence of EBV-1 was identified. Thus, EBV lytic infection was higher in individuals with SLE when compared to other autoimmune diseases with rheumatologic involvement and the lytic activity of the virus precedes corticosteroid-induced immunosuppression. |
publishDate |
2022 |
dc.date.accessioned.fl_str_mv |
2022-05-20T13:55:35Z |
dc.date.available.fl_str_mv |
2022-05-20T13:55:35Z |
dc.date.issued.fl_str_mv |
2022 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FRANÇA, Samires Avelino de Souza et al. Epidemiology of the Epstein–Barr Virus in autoimmune inflammatory rheumatic diseases in Northern Brazil. Viruses, v. 14, n. 4, p. 1-20, Mar. 2022. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/4515 |
dc.identifier.issn.-.fl_str_mv |
1999-4915 |
dc.identifier.doi.-.fl_str_mv |
10.3390/v14040694. |
identifier_str_mv |
FRANÇA, Samires Avelino de Souza et al. Epidemiology of the Epstein–Barr Virus in autoimmune inflammatory rheumatic diseases in Northern Brazil. Viruses, v. 14, n. 4, p. 1-20, Mar. 2022. 1999-4915 10.3390/v14040694. |
url |
https://patua.iec.gov.br/handle/iec/4515 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
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Repositório Digital do Instituto Evandro Chagas (Patuá) |
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Repositório Digital do Instituto Evandro Chagas (Patuá) |
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