Genomic and phylogenetic characterization of brazilian yellow fever virus strains

Detalhes bibliográficos
Autor(a) principal: Nunes, Márcio Roberto Teixeira
Data de Publicação: 2012
Outros Autores: Palacios, Gustavo, Cardoso, Jedson Ferreira, Martins, Lívia Caricio, Sousa Junior, Edivaldo C, Lima, Clayton P. S. de, Medeiros, Daniele Barbosa de Almeida, Savji, Nazir, Desai, Aaloki, Rodrigues, Sueli Guerreiro, Carvalho, Valéria Lima, Lipkin, W. Ian
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: https://patua.iec.gov.br/handle/iec/378
Resumo: Globally, yellow fever virus infects nearly 200,000 people, leading to 30,000 deaths annually. Although the virus is endemic to Latin America, only a single genome from this region has been sequenced. Here, we report 12 Brazilian yellow fever virus completegenomes, their genetic traits, phylogenetic characterization, and phylogeographic dynamics. Variable 3= noncoding region (3=NCR) patterns and specific mutations throughout the open reading frame altered predicted secondary structures. Our findingssuggest that whereas the introduction of yellow fever virus in Brazil led to genotype I-predominant dispersal throughout South and Central Americas, genotype II remained confined to Bolivia, Peru, and the western Brazilian Amazon.
id IEC-2_3f99db35328a3f5cf0ce0c798a5b596f
oai_identifier_str oai:patua.iec.gov.br:iec/378
network_acronym_str IEC-2
network_name_str Repositório Digital do Instituto Evandro Chagas (Patuá)
repository_id_str
spelling Nunes, Márcio Roberto TeixeiraPalacios, GustavoCardoso, Jedson FerreiraMartins, Lívia CaricioSousa Junior, Edivaldo CLima, Clayton P. S. deMedeiros, Daniele Barbosa de AlmeidaSavji, NazirDesai, AalokiRodrigues, Sueli GuerreiroCarvalho, Valéria LimaLipkin, W. Ian2016-01-26T11:22:40Z2016-01-26T11:22:40Z2012NUNES, Márcio Roberto Teixeira et al. Genomic and phylogenetic characterization of brazilian yellow fever virus strains. Journal of Virology, v. 86, n. 24, p. 13263-13271, Dec. 2012https://patua.iec.gov.br/handle/iec/37810.1128/JVI.00565-12Globally, yellow fever virus infects nearly 200,000 people, leading to 30,000 deaths annually. Although the virus is endemic to Latin America, only a single genome from this region has been sequenced. Here, we report 12 Brazilian yellow fever virus completegenomes, their genetic traits, phylogenetic characterization, and phylogeographic dynamics. Variable 3= noncoding region (3=NCR) patterns and specific mutations throughout the open reading frame altered predicted secondary structures. Our findingssuggest that whereas the introduction of yellow fever virus in Brazil led to genotype I-predominant dispersal throughout South and Central Americas, genotype II remained confined to Bolivia, Peru, and the western Brazilian Amazon.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Columbia University. New York, USA.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Columbia University. New York, USA.Columbia University. New York, USA.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Columbia University. New York, USA.application/pdfengAmerican Society for MicrobiologyGenomic and phylogenetic characterization of brazilian yellow fever virus strainsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFebre Amarela / transmissãoVírus da Febre Amarelainfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALGenomic and phylogenetic characterization of brazilian yellow fever virus strains . pdfapplication/pdf2874212https://patua.iec.gov.br/bitstreams/5d1effb1-0b1b-422b-8364-560c22c73739/download10f7d345ad811672561ea5b875556c83MD51TEXTfile_1.pdf.txtfile_1.pdf.txtExtracted texttext/plain40671https://patua.iec.gov.br/bitstreams/14f35e48-8bef-41e5-a50c-acddb2ff0070/downloadee2c0c87f3949ba8fab275bba7f61c0aMD52Genomic and phylogenetic characterization of brazilian yellow fever virus strains . pdf.txtGenomic and phylogenetic characterization of brazilian yellow fever virus strains . pdf.txtExtracted texttext/plain42741https://patua.iec.gov.br/bitstreams/2e2b031c-e4fc-45f2-b7a2-45870d78604f/downloade5ec40bd22176521e95ceed310c38fa2MD57THUMBNAILfile_1.pdf.jpgfile_1.pdf.jpgIM Thumbnailimage/jpeg4723https://patua.iec.gov.br/bitstreams/3b03e71d-192c-454e-8fb3-25f1b8d238ae/download5cc3fa389a2f19c96eeb33efae264b01MD53Genomic and phylogenetic characterization of brazilian yellow fever virus strains . pdf.jpgGenomic and phylogenetic characterization of brazilian yellow fever virus strains . pdf.jpgGenerated Thumbnailimage/jpeg6024https://patua.iec.gov.br/bitstreams/5cb1c2a5-610c-402f-94c9-fc5f2f8e6247/download656da929f1d4d25696edef2af0d2a98dMD58LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/93b0f087-b923-4a8b-a0d3-9995b9b13212/download11832eea31b16df8613079d742d61793MD56iec/3782022-10-20 22:14:12.3oai:patua.iec.gov.br:iec/378https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T22:14:12Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)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
dc.title.pt_BR.fl_str_mv Genomic and phylogenetic characterization of brazilian yellow fever virus strains
title Genomic and phylogenetic characterization of brazilian yellow fever virus strains
spellingShingle Genomic and phylogenetic characterization of brazilian yellow fever virus strains
Nunes, Márcio Roberto Teixeira
Febre Amarela / transmissão
Vírus da Febre Amarela
title_short Genomic and phylogenetic characterization of brazilian yellow fever virus strains
title_full Genomic and phylogenetic characterization of brazilian yellow fever virus strains
title_fullStr Genomic and phylogenetic characterization of brazilian yellow fever virus strains
title_full_unstemmed Genomic and phylogenetic characterization of brazilian yellow fever virus strains
title_sort Genomic and phylogenetic characterization of brazilian yellow fever virus strains
author Nunes, Márcio Roberto Teixeira
author_facet Nunes, Márcio Roberto Teixeira
Palacios, Gustavo
Cardoso, Jedson Ferreira
Martins, Lívia Caricio
Sousa Junior, Edivaldo C
Lima, Clayton P. S. de
Medeiros, Daniele Barbosa de Almeida
Savji, Nazir
Desai, Aaloki
Rodrigues, Sueli Guerreiro
Carvalho, Valéria Lima
Lipkin, W. Ian
author_role author
author2 Palacios, Gustavo
Cardoso, Jedson Ferreira
Martins, Lívia Caricio
Sousa Junior, Edivaldo C
Lima, Clayton P. S. de
Medeiros, Daniele Barbosa de Almeida
Savji, Nazir
Desai, Aaloki
Rodrigues, Sueli Guerreiro
Carvalho, Valéria Lima
Lipkin, W. Ian
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nunes, Márcio Roberto Teixeira
Palacios, Gustavo
Cardoso, Jedson Ferreira
Martins, Lívia Caricio
Sousa Junior, Edivaldo C
Lima, Clayton P. S. de
Medeiros, Daniele Barbosa de Almeida
Savji, Nazir
Desai, Aaloki
Rodrigues, Sueli Guerreiro
Carvalho, Valéria Lima
Lipkin, W. Ian
dc.subject.decsPrimary.pt_BR.fl_str_mv Febre Amarela / transmissão
Vírus da Febre Amarela
topic Febre Amarela / transmissão
Vírus da Febre Amarela
description Globally, yellow fever virus infects nearly 200,000 people, leading to 30,000 deaths annually. Although the virus is endemic to Latin America, only a single genome from this region has been sequenced. Here, we report 12 Brazilian yellow fever virus completegenomes, their genetic traits, phylogenetic characterization, and phylogeographic dynamics. Variable 3= noncoding region (3=NCR) patterns and specific mutations throughout the open reading frame altered predicted secondary structures. Our findingssuggest that whereas the introduction of yellow fever virus in Brazil led to genotype I-predominant dispersal throughout South and Central Americas, genotype II remained confined to Bolivia, Peru, and the western Brazilian Amazon.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2016-01-26T11:22:40Z
dc.date.available.fl_str_mv 2016-01-26T11:22:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv NUNES, Márcio Roberto Teixeira et al. Genomic and phylogenetic characterization of brazilian yellow fever virus strains. Journal of Virology, v. 86, n. 24, p. 13263-13271, Dec. 2012
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/378
dc.identifier.doi.-.fl_str_mv 10.1128/JVI.00565-12
identifier_str_mv NUNES, Márcio Roberto Teixeira et al. Genomic and phylogenetic characterization of brazilian yellow fever virus strains. Journal of Virology, v. 86, n. 24, p. 13263-13271, Dec. 2012
10.1128/JVI.00565-12
url https://patua.iec.gov.br/handle/iec/378
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:Repositório Digital do Instituto Evandro Chagas (Patuá)
instname:Instituto Evandro Chagas (IEC)
instacron:IEC
instname_str Instituto Evandro Chagas (IEC)
instacron_str IEC
institution IEC
reponame_str Repositório Digital do Instituto Evandro Chagas (Patuá)
collection Repositório Digital do Instituto Evandro Chagas (Patuá)
bitstream.url.fl_str_mv https://patua.iec.gov.br/bitstreams/5d1effb1-0b1b-422b-8364-560c22c73739/download
https://patua.iec.gov.br/bitstreams/14f35e48-8bef-41e5-a50c-acddb2ff0070/download
https://patua.iec.gov.br/bitstreams/2e2b031c-e4fc-45f2-b7a2-45870d78604f/download
https://patua.iec.gov.br/bitstreams/3b03e71d-192c-454e-8fb3-25f1b8d238ae/download
https://patua.iec.gov.br/bitstreams/5cb1c2a5-610c-402f-94c9-fc5f2f8e6247/download
https://patua.iec.gov.br/bitstreams/93b0f087-b923-4a8b-a0d3-9995b9b13212/download
bitstream.checksum.fl_str_mv 10f7d345ad811672561ea5b875556c83
ee2c0c87f3949ba8fab275bba7f61c0a
e5ec40bd22176521e95ceed310c38fa2
5cc3fa389a2f19c96eeb33efae264b01
656da929f1d4d25696edef2af0d2a98d
11832eea31b16df8613079d742d61793
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)
repository.mail.fl_str_mv clariceneta@iec.gov.br || Biblioteca@iec.gov.br
_version_ 1809190046268391424