Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/3934 |
Resumo: | Macrophages are a functionally heterogeneous group of cells with specialized functions depending not only on their subgroup but also on the function of the organ or tissue in which the cells are located. The concept of macrophage phenotypic heterogeneity has been investigated since the 1980s, and more recent studies have identified a diverse spectrum of phenotypic subpopulations. Several types of macrophages play a central role in the response to infectious agents and, along with other components of the immune system, determine the clinical outcome of major infectious diseases. Here, we review the functions of various macrophage phenotypic subpopulations, the concept of macrophage polarization, and the influence of these cells on the evolution of infections. In addition, we emphasize their role in the immune response in vivo and in situ, as well as the molecular effectors and signaling mechanisms used by these cells. Furthermore, we highlight the mechanisms of immune evasion triggered by infectious agents to counter the actions of macrophages and their consequences. Our aim here is to provide an overview of the role of macrophages in the pathogenesis of critical transmissible diseases and discuss how elucidation of this relationship could enhance our understanding of the host–pathogen association in organ-specific immune responses |
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Sousa, Jorge Rodrigues deVasconcelos, Pedro Fernando da CostaQuaresma, Juarez Antônio Simões2019-09-25T17:47:50Z2019-09-25T17:47:50Z2019SOUSA, Jorge Rodrigues de; VASCONCELOS, Pedro Fernando da Costa; QUARESMA, Juarez Antônio Simões. Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases. Infection and Drug Resistance, v. 12, p. 2589-2611. 20191178-6973https://patua.iec.gov.br/handle/iec/393410.2147/IDR.S208576Macrophages are a functionally heterogeneous group of cells with specialized functions depending not only on their subgroup but also on the function of the organ or tissue in which the cells are located. The concept of macrophage phenotypic heterogeneity has been investigated since the 1980s, and more recent studies have identified a diverse spectrum of phenotypic subpopulations. Several types of macrophages play a central role in the response to infectious agents and, along with other components of the immune system, determine the clinical outcome of major infectious diseases. Here, we review the functions of various macrophage phenotypic subpopulations, the concept of macrophage polarization, and the influence of these cells on the evolution of infections. In addition, we emphasize their role in the immune response in vivo and in situ, as well as the molecular effectors and signaling mechanisms used by these cells. Furthermore, we highlight the mechanisms of immune evasion triggered by infectious agents to counter the actions of macrophages and their consequences. Our aim here is to provide an overview of the role of macrophages in the pathogenesis of critical transmissible diseases and discuss how elucidation of this relationship could enhance our understanding of the host–pathogen association in organ-specific immune responsesThis work was funded by the Council for Scientific and Technological Development – CNPq/Brazil (Grant numbers 302553/2015-0 and 116427/2016-7) and Coordination of Superior Level Staff Improvement - CAPES/Brazil. Program of support for qualified production – PAPQ/ UFPA.Federal University of Pará. Tropical Medicine Center. Belém, PA, Brazil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil / State University of Pará. Center of Biological and Health Sciences. Belém, PA, Brazil.Federal University of Pará. Tropical Medicine Center. Belém, PA, Brazil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil / State University of Pará. Center of Biological and Health Sciences. Belém, PA, Brazil / University, São Paulo. School of Medicine. 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dc.title.pt_BR.fl_str_mv |
Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases |
title |
Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases |
spellingShingle |
Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases Sousa, Jorge Rodrigues de Macrófagos / citologia Ativação de Macrófagos Fenótipo Doenças Transmissíveis / imunologia |
title_short |
Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases |
title_full |
Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases |
title_fullStr |
Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases |
title_full_unstemmed |
Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases |
title_sort |
Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases |
author |
Sousa, Jorge Rodrigues de |
author_facet |
Sousa, Jorge Rodrigues de Vasconcelos, Pedro Fernando da Costa Quaresma, Juarez Antônio Simões |
author_role |
author |
author2 |
Vasconcelos, Pedro Fernando da Costa Quaresma, Juarez Antônio Simões |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Sousa, Jorge Rodrigues de Vasconcelos, Pedro Fernando da Costa Quaresma, Juarez Antônio Simões |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Macrófagos / citologia Ativação de Macrófagos Fenótipo Doenças Transmissíveis / imunologia |
topic |
Macrófagos / citologia Ativação de Macrófagos Fenótipo Doenças Transmissíveis / imunologia |
description |
Macrophages are a functionally heterogeneous group of cells with specialized functions depending not only on their subgroup but also on the function of the organ or tissue in which the cells are located. The concept of macrophage phenotypic heterogeneity has been investigated since the 1980s, and more recent studies have identified a diverse spectrum of phenotypic subpopulations. Several types of macrophages play a central role in the response to infectious agents and, along with other components of the immune system, determine the clinical outcome of major infectious diseases. Here, we review the functions of various macrophage phenotypic subpopulations, the concept of macrophage polarization, and the influence of these cells on the evolution of infections. In addition, we emphasize their role in the immune response in vivo and in situ, as well as the molecular effectors and signaling mechanisms used by these cells. Furthermore, we highlight the mechanisms of immune evasion triggered by infectious agents to counter the actions of macrophages and their consequences. Our aim here is to provide an overview of the role of macrophages in the pathogenesis of critical transmissible diseases and discuss how elucidation of this relationship could enhance our understanding of the host–pathogen association in organ-specific immune responses |
publishDate |
2019 |
dc.date.accessioned.fl_str_mv |
2019-09-25T17:47:50Z |
dc.date.available.fl_str_mv |
2019-09-25T17:47:50Z |
dc.date.issued.fl_str_mv |
2019 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SOUSA, Jorge Rodrigues de; VASCONCELOS, Pedro Fernando da Costa; QUARESMA, Juarez Antônio Simões. Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases. Infection and Drug Resistance, v. 12, p. 2589-2611. 2019 |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/3934 |
dc.identifier.issn.-.fl_str_mv |
1178-6973 |
dc.identifier.doi.-.fl_str_mv |
10.2147/IDR.S208576 |
identifier_str_mv |
SOUSA, Jorge Rodrigues de; VASCONCELOS, Pedro Fernando da Costa; QUARESMA, Juarez Antônio Simões. Functional aspects, phenotypic heterogeneity, and tissue immune response of macrophages in infectious diseases. Infection and Drug Resistance, v. 12, p. 2589-2611. 2019 1178-6973 10.2147/IDR.S208576 |
url |
https://patua.iec.gov.br/handle/iec/3934 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Dove Medical Press |
publisher.none.fl_str_mv |
Dove Medical Press |
dc.source.none.fl_str_mv |
reponame:Repositório Digital do Instituto Evandro Chagas (Patuá) instname:Instituto Evandro Chagas (IEC) instacron:IEC |
instname_str |
Instituto Evandro Chagas (IEC) |
instacron_str |
IEC |
institution |
IEC |
reponame_str |
Repositório Digital do Instituto Evandro Chagas (Patuá) |
collection |
Repositório Digital do Instituto Evandro Chagas (Patuá) |
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clariceneta@iec.gov.br || Biblioteca@iec.gov.br |
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