Mercury exposure, serum antinuclear / antinucleolar antibodies, and serum cytokine levels in mining populations in Amazonian Brazil: a cross-sectional study

Detalhes bibliográficos
Autor(a) principal: Gardner, Renee M
Data de Publicação: 2010
Outros Autores: Nyland, Jennifer F, Silva, Ines A, Ventura, Ana Maria Revorêdo da Silva, Souza, José Maria de, Silbergeld, Ellen K
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: https://patua.iec.gov.br/handle/iec/3564
Resumo: Mercury is an immunotoxic substance that has been shown to induce autoimmune disease in rodent models, characterized by lymphoproliferation, overproduction of immunoglobulin (IgG and IgE), and high circulating levels of auto-antibodies directed at antigens located in the nucleus (antinuclear auto-antibodies, or ANA) or the nucleolus (antinucleolar auto-antibodies, or ANoA). We have reported elevated levels of ANA and ANoA in human populations exposed to mercury in artisanal gold mining, though other confounding variables that may also modulate ANA/ANoA levels were not well controlled. The goal of this study is to specifically test whether occupational and environmental conditions (other than mercury exposure) that are associated with artisanal gold mining affect the prevalence of markers of autoimmune dysfunction. We measured ANA, ANoA, and cytokine concentrations in serum and compared results from mercury-exposed artisanal gold miners to those from diamond and emerald miners working under similar conditions and with similar socio-economic status and risks of infectious disease. Mercury-exposed gold miners had higher prevalence of detectable ANA and ANoA and higher titers of ANA and ANoA as compared to diamond and emerald miners with no occupational mercury exposure. Also, mercury-exposed gold miners with detectable ANA or ANoA in serum had significantly higher concentrations of pro-inflammatory cytokines IL-1beta, TNF-alpha, and IFN-gamma in serum as compared to the diamond and emerald miners. This study provides further evidence that mercury exposure may lead to autoimmune dysfunction and systemic inflammation in affected populations
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spelling Gardner, Renee MNyland, Jennifer FSilva, Ines AVentura, Ana Maria Revorêdo da SilvaSouza, José Maria deSilbergeld, Ellen K2019-01-22T13:25:24Z2019-01-22T13:25:24Z2010GARDNER, Renee M. et al. Mercury exposure, serum antinuclear / antinucleolar antibodies, and serum cytokine levels in mining populations in Amazonian Brazil: a cross-sectional study. Environmental Research, v. 110, n. 4, p. 345-354, 2010.0013-9351https://patua.iec.gov.br/handle/iec/356410.1016/j.envres.2010.02.001Mercury is an immunotoxic substance that has been shown to induce autoimmune disease in rodent models, characterized by lymphoproliferation, overproduction of immunoglobulin (IgG and IgE), and high circulating levels of auto-antibodies directed at antigens located in the nucleus (antinuclear auto-antibodies, or ANA) or the nucleolus (antinucleolar auto-antibodies, or ANoA). We have reported elevated levels of ANA and ANoA in human populations exposed to mercury in artisanal gold mining, though other confounding variables that may also modulate ANA/ANoA levels were not well controlled. The goal of this study is to specifically test whether occupational and environmental conditions (other than mercury exposure) that are associated with artisanal gold mining affect the prevalence of markers of autoimmune dysfunction. We measured ANA, ANoA, and cytokine concentrations in serum and compared results from mercury-exposed artisanal gold miners to those from diamond and emerald miners working under similar conditions and with similar socio-economic status and risks of infectious disease. Mercury-exposed gold miners had higher prevalence of detectable ANA and ANoA and higher titers of ANA and ANoA as compared to diamond and emerald miners with no occupational mercury exposure. Also, mercury-exposed gold miners with detectable ANA or ANoA in serum had significantly higher concentrations of pro-inflammatory cytokines IL-1beta, TNF-alpha, and IFN-gamma in serum as compared to the diamond and emerald miners. This study provides further evidence that mercury exposure may lead to autoimmune dysfunction and systemic inflammation in affected populationsJohns Hopkins Bloomberg School of Public Health. Department of Environmental Health Sciences. Baltimore, MD, USA.Johns Hopkins Bloomberg School of Public Health. Department of Environmental Health Sciences. Baltimore, MD, USA / University of South Carolina School of Medicine. Department of Pathology, Microbiology & Immunology. Columbia, SC, USA.Johns Hopkins Bloomberg School of Public Health. Department of Environmental Health Sciences. Baltimore, MD, USA.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Johns Hopkins Bloomberg School of Public Health. Department of Environmental Health Sciences. Baltimore, MD, USA.engElsevierMercury exposure, serum antinuclear / antinucleolar antibodies, and serum cytokine levels in mining populations in Amazonian Brazil: a cross-sectional studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMercúrio / toxicidadeBiomarcadoresDiamanteEstudos Transversaisinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALMercury exposure, serum antinuclear / antinucleolar antibodies, and serum cytokine levels in mining populations in Amazonian Brazil: a cross-sectional study.pdfMercury exposure, serum antinuclear / antinucleolar antibodies, and serum cytokine levels in mining populations in Amazonian Brazil: a cross-sectional study.pdfapplication/pdf885850https://patua.iec.gov.br/bitstreams/2a70acbd-8d2a-411c-9b47-abf94888ba49/download3d1b4e87191916d3eb200db5f7e735f6MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/aa172564-fc51-4280-b949-5adc638b5875/download11832eea31b16df8613079d742d61793MD52TEXTMercury exposure, serum antinuclear / antinucleolar antibodies, and serum cytokine levels in mining populations in Amazonian Brazil: a cross-sectional study.pdf.txtMercury exposure, serum antinuclear / antinucleolar antibodies, and serum cytokine levels in mining populations in Amazonian Brazil: a cross-sectional study.pdf.txtExtracted texttext/plain59685https://patua.iec.gov.br/bitstreams/c2db78d6-9a65-47dd-8414-c9a4608e72a2/download79363794e94c07cded669a5c279d6980MD55THUMBNAILMercury exposure, serum antinuclear / antinucleolar antibodies, and serum cytokine levels in mining populations in Amazonian Brazil: a cross-sectional study.pdf.jpgMercury exposure, serum antinuclear / antinucleolar antibodies, and serum cytokine levels in mining populations in Amazonian Brazil: a cross-sectional study.pdf.jpgGenerated Thumbnailimage/jpeg6000https://patua.iec.gov.br/bitstreams/ae3d0796-adf3-41bc-834b-95b1eb803fff/download7adcc3fc4dac4b13f177e561338cc127MD56iec/35642022-10-20 22:49:11.861oai:patua.iec.gov.br:iec/3564https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T22:49:11Repositório Digital do Instituto Evandro Chagas (Patuá) - 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dc.title.pt_BR.fl_str_mv Mercury exposure, serum antinuclear / antinucleolar antibodies, and serum cytokine levels in mining populations in Amazonian Brazil: a cross-sectional study
title Mercury exposure, serum antinuclear / antinucleolar antibodies, and serum cytokine levels in mining populations in Amazonian Brazil: a cross-sectional study
spellingShingle Mercury exposure, serum antinuclear / antinucleolar antibodies, and serum cytokine levels in mining populations in Amazonian Brazil: a cross-sectional study
Gardner, Renee M
Mercúrio / toxicidade
Biomarcadores
Diamante
Estudos Transversais
title_short Mercury exposure, serum antinuclear / antinucleolar antibodies, and serum cytokine levels in mining populations in Amazonian Brazil: a cross-sectional study
title_full Mercury exposure, serum antinuclear / antinucleolar antibodies, and serum cytokine levels in mining populations in Amazonian Brazil: a cross-sectional study
title_fullStr Mercury exposure, serum antinuclear / antinucleolar antibodies, and serum cytokine levels in mining populations in Amazonian Brazil: a cross-sectional study
title_full_unstemmed Mercury exposure, serum antinuclear / antinucleolar antibodies, and serum cytokine levels in mining populations in Amazonian Brazil: a cross-sectional study
title_sort Mercury exposure, serum antinuclear / antinucleolar antibodies, and serum cytokine levels in mining populations in Amazonian Brazil: a cross-sectional study
author Gardner, Renee M
author_facet Gardner, Renee M
Nyland, Jennifer F
Silva, Ines A
Ventura, Ana Maria Revorêdo da Silva
Souza, José Maria de
Silbergeld, Ellen K
author_role author
author2 Nyland, Jennifer F
Silva, Ines A
Ventura, Ana Maria Revorêdo da Silva
Souza, José Maria de
Silbergeld, Ellen K
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Gardner, Renee M
Nyland, Jennifer F
Silva, Ines A
Ventura, Ana Maria Revorêdo da Silva
Souza, José Maria de
Silbergeld, Ellen K
dc.subject.decsPrimary.pt_BR.fl_str_mv Mercúrio / toxicidade
Biomarcadores
Diamante
Estudos Transversais
topic Mercúrio / toxicidade
Biomarcadores
Diamante
Estudos Transversais
description Mercury is an immunotoxic substance that has been shown to induce autoimmune disease in rodent models, characterized by lymphoproliferation, overproduction of immunoglobulin (IgG and IgE), and high circulating levels of auto-antibodies directed at antigens located in the nucleus (antinuclear auto-antibodies, or ANA) or the nucleolus (antinucleolar auto-antibodies, or ANoA). We have reported elevated levels of ANA and ANoA in human populations exposed to mercury in artisanal gold mining, though other confounding variables that may also modulate ANA/ANoA levels were not well controlled. The goal of this study is to specifically test whether occupational and environmental conditions (other than mercury exposure) that are associated with artisanal gold mining affect the prevalence of markers of autoimmune dysfunction. We measured ANA, ANoA, and cytokine concentrations in serum and compared results from mercury-exposed artisanal gold miners to those from diamond and emerald miners working under similar conditions and with similar socio-economic status and risks of infectious disease. Mercury-exposed gold miners had higher prevalence of detectable ANA and ANoA and higher titers of ANA and ANoA as compared to diamond and emerald miners with no occupational mercury exposure. Also, mercury-exposed gold miners with detectable ANA or ANoA in serum had significantly higher concentrations of pro-inflammatory cytokines IL-1beta, TNF-alpha, and IFN-gamma in serum as compared to the diamond and emerald miners. This study provides further evidence that mercury exposure may lead to autoimmune dysfunction and systemic inflammation in affected populations
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2019-01-22T13:25:24Z
dc.date.available.fl_str_mv 2019-01-22T13:25:24Z
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dc.identifier.citation.fl_str_mv GARDNER, Renee M. et al. Mercury exposure, serum antinuclear / antinucleolar antibodies, and serum cytokine levels in mining populations in Amazonian Brazil: a cross-sectional study. Environmental Research, v. 110, n. 4, p. 345-354, 2010.
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/3564
dc.identifier.issn.-.fl_str_mv 0013-9351
dc.identifier.doi.-.fl_str_mv 10.1016/j.envres.2010.02.001
identifier_str_mv GARDNER, Renee M. et al. Mercury exposure, serum antinuclear / antinucleolar antibodies, and serum cytokine levels in mining populations in Amazonian Brazil: a cross-sectional study. Environmental Research, v. 110, n. 4, p. 345-354, 2010.
0013-9351
10.1016/j.envres.2010.02.001
url https://patua.iec.gov.br/handle/iec/3564
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