Analysis of genetic variability of Plasmodium vivax isolates from different Brazilian Amazon areas using tandem repeats
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/3571 |
Resumo: | Few genetic markers have been described to analyze populations of Plasmodium vivax . The genetic variability of P. vivax has been analyzed mainly among isolates taken from areas ranging from hyper- to holoendemic areas. These studies of genetic variability have neglected many areas with different epidemiologic profiles. The purpose of this study was to analyze the genetic variability of P. vivax isolates from four different Brazilian Amazon areas. We chose to study the five most polymorphic tandem repeats (TRs) identified so far. All TRs studied were polymorphic in at least one studied population, with a modal allele at nearly all loci. Expected heterozygosity ranged from 0.462 to 0.666 and did not correlate with the repeat array length. The genetic distances among the populations varied from 0.027 to 0.241, and did not correlate with their geographic separation. Tandem repeats identified in P. vivax isolates failed to allow geographic clustering. |
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Rezende, Antônio MSantos, Eduardo TarazonaCouto, Álvaro D'AlmeidaFontes, Cór Jésus FSouza, José Maria deCarvalho, Luzia HBrito, Cristiana F. A2019-01-22T18:06:19Z2019-01-22T18:06:19Z2009REZENDE, Antônio M. et al. Analysis of genetic variability of Plasmodium vivax isolates from different Brazilian Amazon areas using tandem repeats. American Journal of Tropical Medicine and Hygiene, v. 80, n. 5, p. 729-733, 2009.0002-9637https://patua.iec.gov.br/handle/iec/3571Few genetic markers have been described to analyze populations of Plasmodium vivax . The genetic variability of P. vivax has been analyzed mainly among isolates taken from areas ranging from hyper- to holoendemic areas. These studies of genetic variability have neglected many areas with different epidemiologic profiles. The purpose of this study was to analyze the genetic variability of P. vivax isolates from four different Brazilian Amazon areas. We chose to study the five most polymorphic tandem repeats (TRs) identified so far. All TRs studied were polymorphic in at least one studied population, with a modal allele at nearly all loci. Expected heterozygosity ranged from 0.462 to 0.666 and did not correlate with the repeat array length. The genetic distances among the populations varied from 0.027 to 0.241, and did not correlate with their geographic separation. Tandem repeats identified in P. vivax isolates failed to allow geographic clustering.This work was supported by the Fundação de Amparo à Pesquisa de Minas Gerais (Fapemig), the Conselho Nacional de Pesquisa (CNPq), and PAPES/FIOCRUZ.Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratoryo of Malaria. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Biologia Geral. Belo Horizonte, MG, Brazil.Faculdade SEAMA. Macapá, AP, Brazil.Universidade Federal do Mato Grosso. Departamento de Clínica Médica. Cuiabá, MT, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Laboratory of Malaria. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Laboratory of Malaria. Belo Horizonte, MG, Brazil.engAmerican Society of Tropical Medicine and HygieneAnalysis of genetic variability of Plasmodium vivax isolates from different Brazilian Amazon areas using tandem repeatsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMalária Vivax / parasitologiaPlasmodium vivax / genéticaVariação GenéticaMalária Vivax / epidemiologiaBrasil / epidemiologiainfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALAnalysis of genetic variability of Plasmodium vivax isolates from different Brazilian Amazon areas using tandem repeats.pdfAnalysis of genetic variability of Plasmodium vivax isolates from different Brazilian Amazon areas using tandem repeats.pdfapplication/pdf552468https://patua.iec.gov.br/bitstreams/c2912118-e596-477b-8294-b64242a161e7/downloadc29b7dda474d34cbc69abb7116d6f1b5MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/37ad84fe-dfbf-48c7-b9db-bc07537f5e6d/download11832eea31b16df8613079d742d61793MD52TEXTAnalysis of genetic variability of Plasmodium vivax isolates from different Brazilian Amazon areas using tandem repeats.pdf.txtAnalysis of genetic variability of Plasmodium vivax isolates from different Brazilian Amazon areas using tandem repeats.pdf.txtExtracted texttext/plain31050https://patua.iec.gov.br/bitstreams/f1304860-b784-476b-a8b3-fc22fbf014b7/downloadbb4698982762289a3f6eb38426d0e34bMD55THUMBNAILAnalysis of genetic variability of Plasmodium vivax isolates from different Brazilian Amazon areas using tandem repeats.pdf.jpgAnalysis of genetic variability of Plasmodium vivax isolates from different Brazilian Amazon areas using tandem repeats.pdf.jpgGenerated Thumbnailimage/jpeg5922https://patua.iec.gov.br/bitstreams/861e94e5-691d-4b88-a0fa-b76ca83e1706/download7066fe5308051ebae0311217c4618610MD56iec/35712022-10-20 23:15:49.69oai:patua.iec.gov.br:iec/3571https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T23:15:49Repositório Digital do Instituto Evandro Chagas (Patuá) - 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dc.title.pt_BR.fl_str_mv |
Analysis of genetic variability of Plasmodium vivax isolates from different Brazilian Amazon areas using tandem repeats |
title |
Analysis of genetic variability of Plasmodium vivax isolates from different Brazilian Amazon areas using tandem repeats |
spellingShingle |
Analysis of genetic variability of Plasmodium vivax isolates from different Brazilian Amazon areas using tandem repeats Rezende, Antônio M Malária Vivax / parasitologia Plasmodium vivax / genética Variação Genética Malária Vivax / epidemiologia Brasil / epidemiologia |
title_short |
Analysis of genetic variability of Plasmodium vivax isolates from different Brazilian Amazon areas using tandem repeats |
title_full |
Analysis of genetic variability of Plasmodium vivax isolates from different Brazilian Amazon areas using tandem repeats |
title_fullStr |
Analysis of genetic variability of Plasmodium vivax isolates from different Brazilian Amazon areas using tandem repeats |
title_full_unstemmed |
Analysis of genetic variability of Plasmodium vivax isolates from different Brazilian Amazon areas using tandem repeats |
title_sort |
Analysis of genetic variability of Plasmodium vivax isolates from different Brazilian Amazon areas using tandem repeats |
author |
Rezende, Antônio M |
author_facet |
Rezende, Antônio M Santos, Eduardo Tarazona Couto, Álvaro D'Almeida Fontes, Cór Jésus F Souza, José Maria de Carvalho, Luzia H Brito, Cristiana F. A |
author_role |
author |
author2 |
Santos, Eduardo Tarazona Couto, Álvaro D'Almeida Fontes, Cór Jésus F Souza, José Maria de Carvalho, Luzia H Brito, Cristiana F. A |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Rezende, Antônio M Santos, Eduardo Tarazona Couto, Álvaro D'Almeida Fontes, Cór Jésus F Souza, José Maria de Carvalho, Luzia H Brito, Cristiana F. A |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Malária Vivax / parasitologia Plasmodium vivax / genética Variação Genética Malária Vivax / epidemiologia Brasil / epidemiologia |
topic |
Malária Vivax / parasitologia Plasmodium vivax / genética Variação Genética Malária Vivax / epidemiologia Brasil / epidemiologia |
description |
Few genetic markers have been described to analyze populations of Plasmodium vivax . The genetic variability of P. vivax has been analyzed mainly among isolates taken from areas ranging from hyper- to holoendemic areas. These studies of genetic variability have neglected many areas with different epidemiologic profiles. The purpose of this study was to analyze the genetic variability of P. vivax isolates from four different Brazilian Amazon areas. We chose to study the five most polymorphic tandem repeats (TRs) identified so far. All TRs studied were polymorphic in at least one studied population, with a modal allele at nearly all loci. Expected heterozygosity ranged from 0.462 to 0.666 and did not correlate with the repeat array length. The genetic distances among the populations varied from 0.027 to 0.241, and did not correlate with their geographic separation. Tandem repeats identified in P. vivax isolates failed to allow geographic clustering. |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009 |
dc.date.accessioned.fl_str_mv |
2019-01-22T18:06:19Z |
dc.date.available.fl_str_mv |
2019-01-22T18:06:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
REZENDE, Antônio M. et al. Analysis of genetic variability of Plasmodium vivax isolates from different Brazilian Amazon areas using tandem repeats. American Journal of Tropical Medicine and Hygiene, v. 80, n. 5, p. 729-733, 2009. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/3571 |
dc.identifier.issn.-.fl_str_mv |
0002-9637 |
identifier_str_mv |
REZENDE, Antônio M. et al. Analysis of genetic variability of Plasmodium vivax isolates from different Brazilian Amazon areas using tandem repeats. American Journal of Tropical Medicine and Hygiene, v. 80, n. 5, p. 729-733, 2009. 0002-9637 |
url |
https://patua.iec.gov.br/handle/iec/3571 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
American Society of Tropical Medicine and Hygiene |
publisher.none.fl_str_mv |
American Society of Tropical Medicine and Hygiene |
dc.source.none.fl_str_mv |
reponame:Repositório Digital do Instituto Evandro Chagas (Patuá) instname:Instituto Evandro Chagas (IEC) instacron:IEC |
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Instituto Evandro Chagas (IEC) |
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IEC |
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IEC |
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Repositório Digital do Instituto Evandro Chagas (Patuá) |
collection |
Repositório Digital do Instituto Evandro Chagas (Patuá) |
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