Current understanding of the role of cholesterol in the life cycle of Alphaviruses

Detalhes bibliográficos
Autor(a) principal: Sousa Jr, Ivanildo P
Data de Publicação: 2021
Outros Autores: Carvalho, Carlos A. M, Gomes, Andre M. O
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: https://patua.iec.gov.br/handle/iec/4251
Resumo: Enveloped viruses rely on different lipid classes present in cell membranes to accomplish several steps of their life cycle in the host. Particularly for alphaviruses, a medically important group of arboviruses, which are part of the Togaviridae family, cholesterol seems to be a critical lipid exploited during infection, although its relevance may vary depending on which stage of the virus life cycle is under consideration and whether infection takes place in vertebrate or invertebrate hosts. In this review, the role of cholesterol in both early and late events of alphavirus infection and how viral replication may affect cholesterol metabolism are summarized, taking into account studies on Old World and New World alphaviruses in different cell lines. Moreover, the importance of cholesterol for the structural stability of alphavirus particles is also discussed, shedding light on the role played by this lipid when they leave the host cell.
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spelling Sousa Jr, Ivanildo PCarvalho, Carlos A. MGomes, Andre M. O2021-02-08T18:21:31Z2021-02-08T18:21:31Z2021SOUSA JR., Ivanildo P.; CARVALHO, Carlos A. M.; GOMES, Andre M. O. Current understanding of the role of cholesterol in the life cycle of Alphaviruses. Viruses, v. 13, n. 1, p. 1-12, 2021.1999-4915https://patua.iec.gov.br/handle/iec/425110.3390/v13010035.Enveloped viruses rely on different lipid classes present in cell membranes to accomplish several steps of their life cycle in the host. Particularly for alphaviruses, a medically important group of arboviruses, which are part of the Togaviridae family, cholesterol seems to be a critical lipid exploited during infection, although its relevance may vary depending on which stage of the virus life cycle is under consideration and whether infection takes place in vertebrate or invertebrate hosts. In this review, the role of cholesterol in both early and late events of alphavirus infection and how viral replication may affect cholesterol metabolism are summarized, taking into account studies on Old World and New World alphaviruses in different cell lines. Moreover, the importance of cholesterol for the structural stability of alphavirus particles is also discussed, shedding light on the role played by this lipid when they leave the host cell.This work was supported by the Brazilian research funding agencies Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Capes).Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Enterovírus. Rio de Janeiro, RJ, Brazil.Universidade do Estado do Pará. Departamento de Patologia. Centro de Ciências Biológicas e da Saúde. Belém, PA, Brazil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil / Instituto Euro-Americano de Educação. Centro Universitário Metropolitano da Amazônia, Ciência e Tecnologia. Belém, PA, Brazil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Centro de Ciências da Saúde. Rio de Janeiro, RJ, Brazil / Universidade Federal do Rio de Janeiro. Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem. Centro Nacional de Biologia Estrutural e Bioimagem. 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dc.title.pt_BR.fl_str_mv Current understanding of the role of cholesterol in the life cycle of Alphaviruses
title Current understanding of the role of cholesterol in the life cycle of Alphaviruses
spellingShingle Current understanding of the role of cholesterol in the life cycle of Alphaviruses
Sousa Jr, Ivanildo P
Alphavirus / patogenicidade
Colesterol / análise
Infecções por Alphavirus / sangue
title_short Current understanding of the role of cholesterol in the life cycle of Alphaviruses
title_full Current understanding of the role of cholesterol in the life cycle of Alphaviruses
title_fullStr Current understanding of the role of cholesterol in the life cycle of Alphaviruses
title_full_unstemmed Current understanding of the role of cholesterol in the life cycle of Alphaviruses
title_sort Current understanding of the role of cholesterol in the life cycle of Alphaviruses
author Sousa Jr, Ivanildo P
author_facet Sousa Jr, Ivanildo P
Carvalho, Carlos A. M
Gomes, Andre M. O
author_role author
author2 Carvalho, Carlos A. M
Gomes, Andre M. O
author2_role author
author
dc.contributor.author.fl_str_mv Sousa Jr, Ivanildo P
Carvalho, Carlos A. M
Gomes, Andre M. O
dc.subject.decsPrimary.pt_BR.fl_str_mv Alphavirus / patogenicidade
Colesterol / análise
Infecções por Alphavirus / sangue
topic Alphavirus / patogenicidade
Colesterol / análise
Infecções por Alphavirus / sangue
description Enveloped viruses rely on different lipid classes present in cell membranes to accomplish several steps of their life cycle in the host. Particularly for alphaviruses, a medically important group of arboviruses, which are part of the Togaviridae family, cholesterol seems to be a critical lipid exploited during infection, although its relevance may vary depending on which stage of the virus life cycle is under consideration and whether infection takes place in vertebrate or invertebrate hosts. In this review, the role of cholesterol in both early and late events of alphavirus infection and how viral replication may affect cholesterol metabolism are summarized, taking into account studies on Old World and New World alphaviruses in different cell lines. Moreover, the importance of cholesterol for the structural stability of alphavirus particles is also discussed, shedding light on the role played by this lipid when they leave the host cell.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-02-08T18:21:31Z
dc.date.available.fl_str_mv 2021-02-08T18:21:31Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv SOUSA JR., Ivanildo P.; CARVALHO, Carlos A. M.; GOMES, Andre M. O. Current understanding of the role of cholesterol in the life cycle of Alphaviruses. Viruses, v. 13, n. 1, p. 1-12, 2021.
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/4251
dc.identifier.issn.-.fl_str_mv 1999-4915
dc.identifier.doi.-.fl_str_mv 10.3390/v13010035.
identifier_str_mv SOUSA JR., Ivanildo P.; CARVALHO, Carlos A. M.; GOMES, Andre M. O. Current understanding of the role of cholesterol in the life cycle of Alphaviruses. Viruses, v. 13, n. 1, p. 1-12, 2021.
1999-4915
10.3390/v13010035.
url https://patua.iec.gov.br/handle/iec/4251
dc.language.iso.fl_str_mv eng
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