Trisomy 21 and Down syndrome: a short review

Detalhes bibliográficos
Autor(a) principal: Sommer,CA.
Data de Publicação: 2008
Outros Autores: Henrique-Silva,F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842008000200031
Resumo: Even though the molecular mechanisms underlying the Down syndrome (DS) phenotypes remain obscure, the characterization of the genes and conserved non-genic sequences of HSA21 together with large-scale gene expression studies in DS tissues are enhancing our understanding of this complex disorder. Also, mouse models of DS provide invaluable tools to correlate genes or chromosome segments to specific phenotypes. Here we discuss the possible contribution of HSA21 genes to DS and data from global gene expression studies of trisomic samples.
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spelling Trisomy 21 and Down syndrome: a short reviewDown syndrometrisomyHSA21gene-expression analysisEven though the molecular mechanisms underlying the Down syndrome (DS) phenotypes remain obscure, the characterization of the genes and conserved non-genic sequences of HSA21 together with large-scale gene expression studies in DS tissues are enhancing our understanding of this complex disorder. Also, mouse models of DS provide invaluable tools to correlate genes or chromosome segments to specific phenotypes. Here we discuss the possible contribution of HSA21 genes to DS and data from global gene expression studies of trisomic samples.Instituto Internacional de Ecologia2008-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842008000200031Brazilian Journal of Biology v.68 n.2 2008reponame:Brazilian Journal of Biologyinstname:Instituto Internacional de Ecologia (IIE)instacron:IIE10.1590/S1519-69842008000200031info:eu-repo/semantics/openAccessSommer,CA.Henrique-Silva,F.eng2008-07-21T00:00:00Zoai:scielo:S1519-69842008000200031Revistahttps://www.scielo.br/j/bjb/https://old.scielo.br/oai/scielo-oai.phpbjb@bjb.com.br||bjb@bjb.com.br1678-43751519-6984opendoar:2008-07-21T00:00Brazilian Journal of Biology - Instituto Internacional de Ecologia (IIE)false
dc.title.none.fl_str_mv Trisomy 21 and Down syndrome: a short review
title Trisomy 21 and Down syndrome: a short review
spellingShingle Trisomy 21 and Down syndrome: a short review
Sommer,CA.
Down syndrome
trisomy
HSA21
gene-expression analysis
title_short Trisomy 21 and Down syndrome: a short review
title_full Trisomy 21 and Down syndrome: a short review
title_fullStr Trisomy 21 and Down syndrome: a short review
title_full_unstemmed Trisomy 21 and Down syndrome: a short review
title_sort Trisomy 21 and Down syndrome: a short review
author Sommer,CA.
author_facet Sommer,CA.
Henrique-Silva,F.
author_role author
author2 Henrique-Silva,F.
author2_role author
dc.contributor.author.fl_str_mv Sommer,CA.
Henrique-Silva,F.
dc.subject.por.fl_str_mv Down syndrome
trisomy
HSA21
gene-expression analysis
topic Down syndrome
trisomy
HSA21
gene-expression analysis
description Even though the molecular mechanisms underlying the Down syndrome (DS) phenotypes remain obscure, the characterization of the genes and conserved non-genic sequences of HSA21 together with large-scale gene expression studies in DS tissues are enhancing our understanding of this complex disorder. Also, mouse models of DS provide invaluable tools to correlate genes or chromosome segments to specific phenotypes. Here we discuss the possible contribution of HSA21 genes to DS and data from global gene expression studies of trisomic samples.
publishDate 2008
dc.date.none.fl_str_mv 2008-05-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842008000200031
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842008000200031
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1519-69842008000200031
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Instituto Internacional de Ecologia
publisher.none.fl_str_mv Instituto Internacional de Ecologia
dc.source.none.fl_str_mv Brazilian Journal of Biology v.68 n.2 2008
reponame:Brazilian Journal of Biology
instname:Instituto Internacional de Ecologia (IIE)
instacron:IIE
instname_str Instituto Internacional de Ecologia (IIE)
instacron_str IIE
institution IIE
reponame_str Brazilian Journal of Biology
collection Brazilian Journal of Biology
repository.name.fl_str_mv Brazilian Journal of Biology - Instituto Internacional de Ecologia (IIE)
repository.mail.fl_str_mv bjb@bjb.com.br||bjb@bjb.com.br
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