Mini review: immunologic functions of dual oxidases in mucosal systems of vertebrates
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Biology |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842020000400948 |
Resumo: | Abstract Mucosal epithelial cells act as the first immunologic barrier of organisms, and contact directly with pathogens. Therefore, hosts must have differential strategies to combat pathogens efficiently. Reactive oxygen species (ROS), as a kind of oxidizing agents, participates in the early stage of killing pathogens quickly. Recent reports have revealed that dual oxidase (DUOX) plays a key role in mucosal immunity. And the DUOX is a transmembrane protein which produces ROS as their primary enzymatic products. This process is an important pattern for eliminating pathogens. In this review, we highlight the DUOX immunologic functions in the respiratory and digestive tract of vertebrates. |
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Brazilian Journal of Biology |
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Mini review: immunologic functions of dual oxidases in mucosal systems of vertebratesNADPH oxidasesdual oxidaseinnate immunitymucosal immunityAbstract Mucosal epithelial cells act as the first immunologic barrier of organisms, and contact directly with pathogens. Therefore, hosts must have differential strategies to combat pathogens efficiently. Reactive oxygen species (ROS), as a kind of oxidizing agents, participates in the early stage of killing pathogens quickly. Recent reports have revealed that dual oxidase (DUOX) plays a key role in mucosal immunity. And the DUOX is a transmembrane protein which produces ROS as their primary enzymatic products. This process is an important pattern for eliminating pathogens. In this review, we highlight the DUOX immunologic functions in the respiratory and digestive tract of vertebrates.Instituto Internacional de Ecologia2020-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842020000400948Brazilian Journal of Biology v.80 n.4 2020reponame:Brazilian Journal of Biologyinstname:Instituto Internacional de Ecologia (IIE)instacron:IIE10.1590/1519-6984.208749info:eu-repo/semantics/openAccessYang,H. T.Huang,Y. H.Yang,G. W.eng2020-12-03T00:00:00Zoai:scielo:S1519-69842020000400948Revistahttps://www.scielo.br/j/bjb/https://old.scielo.br/oai/scielo-oai.phpbjb@bjb.com.br||bjb@bjb.com.br1678-43751519-6984opendoar:2020-12-03T00:00Brazilian Journal of Biology - Instituto Internacional de Ecologia (IIE)false |
dc.title.none.fl_str_mv |
Mini review: immunologic functions of dual oxidases in mucosal systems of vertebrates |
title |
Mini review: immunologic functions of dual oxidases in mucosal systems of vertebrates |
spellingShingle |
Mini review: immunologic functions of dual oxidases in mucosal systems of vertebrates Yang,H. T. NADPH oxidases dual oxidase innate immunity mucosal immunity |
title_short |
Mini review: immunologic functions of dual oxidases in mucosal systems of vertebrates |
title_full |
Mini review: immunologic functions of dual oxidases in mucosal systems of vertebrates |
title_fullStr |
Mini review: immunologic functions of dual oxidases in mucosal systems of vertebrates |
title_full_unstemmed |
Mini review: immunologic functions of dual oxidases in mucosal systems of vertebrates |
title_sort |
Mini review: immunologic functions of dual oxidases in mucosal systems of vertebrates |
author |
Yang,H. T. |
author_facet |
Yang,H. T. Huang,Y. H. Yang,G. W. |
author_role |
author |
author2 |
Huang,Y. H. Yang,G. W. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Yang,H. T. Huang,Y. H. Yang,G. W. |
dc.subject.por.fl_str_mv |
NADPH oxidases dual oxidase innate immunity mucosal immunity |
topic |
NADPH oxidases dual oxidase innate immunity mucosal immunity |
description |
Abstract Mucosal epithelial cells act as the first immunologic barrier of organisms, and contact directly with pathogens. Therefore, hosts must have differential strategies to combat pathogens efficiently. Reactive oxygen species (ROS), as a kind of oxidizing agents, participates in the early stage of killing pathogens quickly. Recent reports have revealed that dual oxidase (DUOX) plays a key role in mucosal immunity. And the DUOX is a transmembrane protein which produces ROS as their primary enzymatic products. This process is an important pattern for eliminating pathogens. In this review, we highlight the DUOX immunologic functions in the respiratory and digestive tract of vertebrates. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842020000400948 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1519-69842020000400948 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1519-6984.208749 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Internacional de Ecologia |
publisher.none.fl_str_mv |
Instituto Internacional de Ecologia |
dc.source.none.fl_str_mv |
Brazilian Journal of Biology v.80 n.4 2020 reponame:Brazilian Journal of Biology instname:Instituto Internacional de Ecologia (IIE) instacron:IIE |
instname_str |
Instituto Internacional de Ecologia (IIE) |
instacron_str |
IIE |
institution |
IIE |
reponame_str |
Brazilian Journal of Biology |
collection |
Brazilian Journal of Biology |
repository.name.fl_str_mv |
Brazilian Journal of Biology - Instituto Internacional de Ecologia (IIE) |
repository.mail.fl_str_mv |
bjb@bjb.com.br||bjb@bjb.com.br |
_version_ |
1752129887072681985 |