Physical training reverses changes in hepatic mitochondrial diameter of Alloxan-induced diabetic rats
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Einstein (São Paulo) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082018000300205 |
Resumo: | ABSTRACT Objective To investigate the effects of physical training on metabolic and morphological parameters of diabetic rats. Methods Wistar rats were randomized into four groups: sedentary control, trained control, sedentary diabetic and trained diabetic. Diabetes mellitus was induced by Alloxan (35mg/kg) administration for sedentary diabetic and Trained Diabetic Groups. The exercise protocol consisted of swimming with a load of 2.5% of body weight for 60 minutes per day (5 days per week) for the trained control and Trained Diabetic Groups, during 6 weeks. At the end of the experiment, the rats were sacrificed and blood was collected for determinations of serum glucose, insulin, albumin and total protein. Liver samples were extracted for measurements of glycogen, protein, DNA and mitochondrial diameter determination. Results The sedentary diabetic animals presented decreased body weight, blood insulin, and hepatic glycogen, as well as increased glycemia and mitochondrial diameter. The physical training protocol in diabetic animals was efficient to recovery body weight and liver glycogen, and to decrease the hepatic mitochondrial diameter. Conclusion Physical training ameliorated hepatic metabolism and promoted important morphologic adaptations as mitochondrial diameter in liver of the diabetic rats. |
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Physical training reverses changes in hepatic mitochondrial diameter of Alloxan-induced diabetic ratsDiabetes mellitusExerciseLiverWistar, ratsABSTRACT Objective To investigate the effects of physical training on metabolic and morphological parameters of diabetic rats. Methods Wistar rats were randomized into four groups: sedentary control, trained control, sedentary diabetic and trained diabetic. Diabetes mellitus was induced by Alloxan (35mg/kg) administration for sedentary diabetic and Trained Diabetic Groups. The exercise protocol consisted of swimming with a load of 2.5% of body weight for 60 minutes per day (5 days per week) for the trained control and Trained Diabetic Groups, during 6 weeks. At the end of the experiment, the rats were sacrificed and blood was collected for determinations of serum glucose, insulin, albumin and total protein. Liver samples were extracted for measurements of glycogen, protein, DNA and mitochondrial diameter determination. Results The sedentary diabetic animals presented decreased body weight, blood insulin, and hepatic glycogen, as well as increased glycemia and mitochondrial diameter. The physical training protocol in diabetic animals was efficient to recovery body weight and liver glycogen, and to decrease the hepatic mitochondrial diameter. Conclusion Physical training ameliorated hepatic metabolism and promoted important morphologic adaptations as mitochondrial diameter in liver of the diabetic rats.Instituto Israelita de Ensino e Pesquisa Albert Einstein2018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082018000300205einstein (São Paulo) v.16 n.3 2018reponame:Einstein (São Paulo)instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)instacron:IIEPAE10.1590/s1679-45082018ao4353info:eu-repo/semantics/openAccessKuga,Gabriel KeineGaspar,Rafael CalaisMuñoz,Vitor RosettoNakandakari,Susana Castelo Branco RamosBreda,LeonardoSandoval,Bruna MarinaCaetano,Flávio HenriqueLeme,José Alexandre Curiacos de AlmeidaPauli,José RodrigoGomes,Ricardo Joséeng2018-08-02T00:00:00Zoai:scielo:S1679-45082018000300205Revistahttps://journal.einstein.br/pt-br/ONGhttps://old.scielo.br/oai/scielo-oai.php||revista@einstein.br2317-63851679-4508opendoar:2018-08-02T00:00Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE)false |
dc.title.none.fl_str_mv |
Physical training reverses changes in hepatic mitochondrial diameter of Alloxan-induced diabetic rats |
title |
Physical training reverses changes in hepatic mitochondrial diameter of Alloxan-induced diabetic rats |
spellingShingle |
Physical training reverses changes in hepatic mitochondrial diameter of Alloxan-induced diabetic rats Kuga,Gabriel Keine Diabetes mellitus Exercise Liver Wistar, rats |
title_short |
Physical training reverses changes in hepatic mitochondrial diameter of Alloxan-induced diabetic rats |
title_full |
Physical training reverses changes in hepatic mitochondrial diameter of Alloxan-induced diabetic rats |
title_fullStr |
Physical training reverses changes in hepatic mitochondrial diameter of Alloxan-induced diabetic rats |
title_full_unstemmed |
Physical training reverses changes in hepatic mitochondrial diameter of Alloxan-induced diabetic rats |
title_sort |
Physical training reverses changes in hepatic mitochondrial diameter of Alloxan-induced diabetic rats |
author |
Kuga,Gabriel Keine |
author_facet |
Kuga,Gabriel Keine Gaspar,Rafael Calais Muñoz,Vitor Rosetto Nakandakari,Susana Castelo Branco Ramos Breda,Leonardo Sandoval,Bruna Marina Caetano,Flávio Henrique Leme,José Alexandre Curiacos de Almeida Pauli,José Rodrigo Gomes,Ricardo José |
author_role |
author |
author2 |
Gaspar,Rafael Calais Muñoz,Vitor Rosetto Nakandakari,Susana Castelo Branco Ramos Breda,Leonardo Sandoval,Bruna Marina Caetano,Flávio Henrique Leme,José Alexandre Curiacos de Almeida Pauli,José Rodrigo Gomes,Ricardo José |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Kuga,Gabriel Keine Gaspar,Rafael Calais Muñoz,Vitor Rosetto Nakandakari,Susana Castelo Branco Ramos Breda,Leonardo Sandoval,Bruna Marina Caetano,Flávio Henrique Leme,José Alexandre Curiacos de Almeida Pauli,José Rodrigo Gomes,Ricardo José |
dc.subject.por.fl_str_mv |
Diabetes mellitus Exercise Liver Wistar, rats |
topic |
Diabetes mellitus Exercise Liver Wistar, rats |
description |
ABSTRACT Objective To investigate the effects of physical training on metabolic and morphological parameters of diabetic rats. Methods Wistar rats were randomized into four groups: sedentary control, trained control, sedentary diabetic and trained diabetic. Diabetes mellitus was induced by Alloxan (35mg/kg) administration for sedentary diabetic and Trained Diabetic Groups. The exercise protocol consisted of swimming with a load of 2.5% of body weight for 60 minutes per day (5 days per week) for the trained control and Trained Diabetic Groups, during 6 weeks. At the end of the experiment, the rats were sacrificed and blood was collected for determinations of serum glucose, insulin, albumin and total protein. Liver samples were extracted for measurements of glycogen, protein, DNA and mitochondrial diameter determination. Results The sedentary diabetic animals presented decreased body weight, blood insulin, and hepatic glycogen, as well as increased glycemia and mitochondrial diameter. The physical training protocol in diabetic animals was efficient to recovery body weight and liver glycogen, and to decrease the hepatic mitochondrial diameter. Conclusion Physical training ameliorated hepatic metabolism and promoted important morphologic adaptations as mitochondrial diameter in liver of the diabetic rats. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082018000300205 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082018000300205 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s1679-45082018ao4353 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
publisher.none.fl_str_mv |
Instituto Israelita de Ensino e Pesquisa Albert Einstein |
dc.source.none.fl_str_mv |
einstein (São Paulo) v.16 n.3 2018 reponame:Einstein (São Paulo) instname:Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) instacron:IIEPAE |
instname_str |
Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
instacron_str |
IIEPAE |
institution |
IIEPAE |
reponame_str |
Einstein (São Paulo) |
collection |
Einstein (São Paulo) |
repository.name.fl_str_mv |
Einstein (São Paulo) - Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE) |
repository.mail.fl_str_mv |
||revista@einstein.br |
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1752129909258452992 |