Mycophenolate mofetil may protect against Pneumocystis carinii pneumonia in renal transplanted patients

Detalhes bibliográficos
Autor(a) principal: Azevedo, Luiz Sergio
Data de Publicação: 2005
Outros Autores: Castro, Maria Cristina R., Paula, Flavio J., Ianhez, Luiz Estevam, David-Neto, Elias
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/30907
Resumo: Pneumocystis carinii pneumonia (PCP) is usually prevented in transplanted patients by prophylactic trimethoprim-sulfamethoxazol (TMS). Mycophenolate mofetil (MMF) has been shown to have a strong protective effect against PCP in rats. This effect is also suggested in humans by the absence of PCP in patients receiving MMF. After January 1998 MMF has been used with no TMS prophylaxis in renal transplanted patients. In azathioprine (AZA) treated patients TMS prophylaxis was maintained. The incidence of PCP was analyzed in both groups. Data were collected in order to have a minimum 6-month follow-up. Two hundred and seventy-two patients were eligible for analysis. No PCP occurred either in patients under MMF without TMS prophylaxis nor in patients under AZA. MMF may have an effective protective role against PCP as no patient under MMF, despite not receiving TMS coverage, developed PCP. A larger, controlled, trial is warranted to consolidate this information.
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spelling Mycophenolate mofetil may protect against Pneumocystis carinii pneumonia in renal transplanted patients Micofenolato mofetil pode proteger contra a pneumonia por Pneumocystis carinii em transplantados renais Kidney transplantationMycophenolate mofetilPneumocystis cariniiPneumoniaImmunosuppression Pneumocystis carinii pneumonia (PCP) is usually prevented in transplanted patients by prophylactic trimethoprim-sulfamethoxazol (TMS). Mycophenolate mofetil (MMF) has been shown to have a strong protective effect against PCP in rats. This effect is also suggested in humans by the absence of PCP in patients receiving MMF. After January 1998 MMF has been used with no TMS prophylaxis in renal transplanted patients. In azathioprine (AZA) treated patients TMS prophylaxis was maintained. The incidence of PCP was analyzed in both groups. Data were collected in order to have a minimum 6-month follow-up. Two hundred and seventy-two patients were eligible for analysis. No PCP occurred either in patients under MMF without TMS prophylaxis nor in patients under AZA. MMF may have an effective protective role against PCP as no patient under MMF, despite not receiving TMS coverage, developed PCP. A larger, controlled, trial is warranted to consolidate this information. A pneumonia por Pneumocystis carinii (PPC) em transplantados renais é, habitualmente, prevenida pelo uso profilático de trimetoprim-sulfametoxazol (TMS). Foi demonstrado que o micofenolato mofetil (MMF) exerce um poderoso efeito protetor sobre a PPC experimental em ratos. Este efeito também foi sugerido em humanos pela ausência de PPC em pacientes recebendo MMF. A partir de janeiro de 1998 passamos a usar o MMF em transplantados renais sem profilaxia por TMS. Nos pacientes recebendo azatioprina (AZA) a profilaxia com TMS continuou a ser empregada. A incidência de PPC foi analisada em ambos os grupos. Os dados foram coletados após um mínimo de seis meses de seguimento. Foram analisados 272 pacientes. Não ocorreu nenhum caso de PPC tanto nos pacientes recebendo MMF como naqueles recebendo AZA. O MMF pode ter exercido um efeito protetor contra a PPC, já que nenhum paciente sob MMF e sem receber profilaxia por TMS desenvolveu PPC. Estudos maiores e controlados se fazem necessários para confirmar estas informações. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2005-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/30907Revista do Instituto de Medicina Tropical de São Paulo; Vol. 47 No. 3 (2005); 143-145 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 47 Núm. 3 (2005); 143-145 Revista do Instituto de Medicina Tropical de São Paulo; v. 47 n. 3 (2005); 143-145 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/30907/32791Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessAzevedo, Luiz SergioCastro, Maria Cristina R.Paula, Flavio J.Ianhez, Luiz EstevamDavid-Neto, Elias2012-07-07T18:36:32Zoai:revistas.usp.br:article/30907Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:51:38.217909Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Mycophenolate mofetil may protect against Pneumocystis carinii pneumonia in renal transplanted patients
Micofenolato mofetil pode proteger contra a pneumonia por Pneumocystis carinii em transplantados renais
title Mycophenolate mofetil may protect against Pneumocystis carinii pneumonia in renal transplanted patients
spellingShingle Mycophenolate mofetil may protect against Pneumocystis carinii pneumonia in renal transplanted patients
Azevedo, Luiz Sergio
Kidney transplantation
Mycophenolate mofetil
Pneumocystis carinii
Pneumonia
Immunosuppression
title_short Mycophenolate mofetil may protect against Pneumocystis carinii pneumonia in renal transplanted patients
title_full Mycophenolate mofetil may protect against Pneumocystis carinii pneumonia in renal transplanted patients
title_fullStr Mycophenolate mofetil may protect against Pneumocystis carinii pneumonia in renal transplanted patients
title_full_unstemmed Mycophenolate mofetil may protect against Pneumocystis carinii pneumonia in renal transplanted patients
title_sort Mycophenolate mofetil may protect against Pneumocystis carinii pneumonia in renal transplanted patients
author Azevedo, Luiz Sergio
author_facet Azevedo, Luiz Sergio
Castro, Maria Cristina R.
Paula, Flavio J.
Ianhez, Luiz Estevam
David-Neto, Elias
author_role author
author2 Castro, Maria Cristina R.
Paula, Flavio J.
Ianhez, Luiz Estevam
David-Neto, Elias
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Azevedo, Luiz Sergio
Castro, Maria Cristina R.
Paula, Flavio J.
Ianhez, Luiz Estevam
David-Neto, Elias
dc.subject.por.fl_str_mv Kidney transplantation
Mycophenolate mofetil
Pneumocystis carinii
Pneumonia
Immunosuppression
topic Kidney transplantation
Mycophenolate mofetil
Pneumocystis carinii
Pneumonia
Immunosuppression
description Pneumocystis carinii pneumonia (PCP) is usually prevented in transplanted patients by prophylactic trimethoprim-sulfamethoxazol (TMS). Mycophenolate mofetil (MMF) has been shown to have a strong protective effect against PCP in rats. This effect is also suggested in humans by the absence of PCP in patients receiving MMF. After January 1998 MMF has been used with no TMS prophylaxis in renal transplanted patients. In azathioprine (AZA) treated patients TMS prophylaxis was maintained. The incidence of PCP was analyzed in both groups. Data were collected in order to have a minimum 6-month follow-up. Two hundred and seventy-two patients were eligible for analysis. No PCP occurred either in patients under MMF without TMS prophylaxis nor in patients under AZA. MMF may have an effective protective role against PCP as no patient under MMF, despite not receiving TMS coverage, developed PCP. A larger, controlled, trial is warranted to consolidate this information.
publishDate 2005
dc.date.none.fl_str_mv 2005-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/30907
url https://www.revistas.usp.br/rimtsp/article/view/30907
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/30907/32791
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 47 No. 3 (2005); 143-145
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 47 Núm. 3 (2005); 143-145
Revista do Instituto de Medicina Tropical de São Paulo; v. 47 n. 3 (2005); 143-145
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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