Hepatitis B vaccine - proposal for a standardized assessment of immune response

Detalhes bibliográficos
Autor(a) principal: Ferraz, Maria Lucia G.
Data de Publicação: 1992
Outros Autores: Silva, Antonio Eduardo, Yamamoto, Marico, Guimaråes, Rubens Xavier
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/28907
Resumo: The authors developed a comparative study of the various methods of assessment of immune response to Hepatitis B vaccine. Eighty-six health care professionals underwent a vaccination programme with three doses of plasma-derived vaccine against Hepatitis B (H-B-Vax, Merck, Sharp & Dohme) given intra-muscularly. Assessment of immune response was carried out three months after the end of the programme, by radioimmunoassay (RIA) and enzymeimmunoassay (EIA). The results showed that the semi-quantitative assessment of Anti-HBs antibodies by RIA or EIA was perfectly comparable to the reference method (quantitative determination of antibodies by RIA). In view of these findings, the authors suggest a standardization of assessment of immune response to the vaccine, thus permitting correct planning of booster doses and easier comparison between different studies
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spelling Hepatitis B vaccine - proposal for a standardized assessment of immune response Vacinação contra Hepatite B - proposta de padronização da avaliação da resposta imunológica Hepatitis BHepatitis B VaccineAnti-HBSAntibodies The authors developed a comparative study of the various methods of assessment of immune response to Hepatitis B vaccine. Eighty-six health care professionals underwent a vaccination programme with three doses of plasma-derived vaccine against Hepatitis B (H-B-Vax, Merck, Sharp & Dohme) given intra-muscularly. Assessment of immune response was carried out three months after the end of the programme, by radioimmunoassay (RIA) and enzymeimmunoassay (EIA). The results showed that the semi-quantitative assessment of Anti-HBs antibodies by RIA or EIA was perfectly comparable to the reference method (quantitative determination of antibodies by RIA). In view of these findings, the authors suggest a standardization of assessment of immune response to the vaccine, thus permitting correct planning of booster doses and easier comparison between different studies Os autores realizaram estudo comparativo dos diferentes métodos de avaliação da resposta à vacina contra hepatite B. Foram estudados 86 indivíduos, profissionais da área de saúde, que foram submetidos a esquema de vacinação com três doses de vacina plasmática contra hepatite B (H-B-Vax, Merck, Sharp & Dohme), aplicadas por via intramuscular. A avaliação da resposta imunológica à vacina foi realizada três meses após o término do esquema, através tanto de radioimunoensaio como enzimaimunoensaio. Os resultados obtidos demonstraram que a avaliação semi-quantitativa dos anticorpos anti-HBs por enzimaimunoensaio é perfeitamente superponível ao método de referência, que é a determinação quantitativa de anticorpos por radioimunoensaio. Tendo em vista estes achados, os autores propõem uma padronização da avaliação da resposta à vacina, com o objetivo de predizer a ocasião das doses de reforço e tornar os diferentes estudos comparáveis entre si Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1992-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/28907Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 No. 2 (1992); 137-140 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 Núm. 2 (1992); 137-140 Revista do Instituto de Medicina Tropical de São Paulo; v. 34 n. 2 (1992); 137-140 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/28907/30762Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessFerraz, Maria Lucia G.Silva, Antonio EduardoYamamoto, MaricoGuimaråes, Rubens Xavier2012-07-02T01:32:42Zoai:revistas.usp.br:article/28907Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:50:40.317635Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true
dc.title.none.fl_str_mv Hepatitis B vaccine - proposal for a standardized assessment of immune response
Vacinação contra Hepatite B - proposta de padronização da avaliação da resposta imunológica
title Hepatitis B vaccine - proposal for a standardized assessment of immune response
spellingShingle Hepatitis B vaccine - proposal for a standardized assessment of immune response
Ferraz, Maria Lucia G.
Hepatitis B
Hepatitis B Vaccine
Anti-HBS
Antibodies
title_short Hepatitis B vaccine - proposal for a standardized assessment of immune response
title_full Hepatitis B vaccine - proposal for a standardized assessment of immune response
title_fullStr Hepatitis B vaccine - proposal for a standardized assessment of immune response
title_full_unstemmed Hepatitis B vaccine - proposal for a standardized assessment of immune response
title_sort Hepatitis B vaccine - proposal for a standardized assessment of immune response
author Ferraz, Maria Lucia G.
author_facet Ferraz, Maria Lucia G.
Silva, Antonio Eduardo
Yamamoto, Marico
Guimaråes, Rubens Xavier
author_role author
author2 Silva, Antonio Eduardo
Yamamoto, Marico
Guimaråes, Rubens Xavier
author2_role author
author
author
dc.contributor.author.fl_str_mv Ferraz, Maria Lucia G.
Silva, Antonio Eduardo
Yamamoto, Marico
Guimaråes, Rubens Xavier
dc.subject.por.fl_str_mv Hepatitis B
Hepatitis B Vaccine
Anti-HBS
Antibodies
topic Hepatitis B
Hepatitis B Vaccine
Anti-HBS
Antibodies
description The authors developed a comparative study of the various methods of assessment of immune response to Hepatitis B vaccine. Eighty-six health care professionals underwent a vaccination programme with three doses of plasma-derived vaccine against Hepatitis B (H-B-Vax, Merck, Sharp & Dohme) given intra-muscularly. Assessment of immune response was carried out three months after the end of the programme, by radioimmunoassay (RIA) and enzymeimmunoassay (EIA). The results showed that the semi-quantitative assessment of Anti-HBs antibodies by RIA or EIA was perfectly comparable to the reference method (quantitative determination of antibodies by RIA). In view of these findings, the authors suggest a standardization of assessment of immune response to the vaccine, thus permitting correct planning of booster doses and easier comparison between different studies
publishDate 1992
dc.date.none.fl_str_mv 1992-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28907
url https://www.revistas.usp.br/rimtsp/article/view/28907
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/28907/30762
dc.rights.driver.fl_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 No. 2 (1992); 137-140
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 34 Núm. 2 (1992); 137-140
Revista do Instituto de Medicina Tropical de São Paulo; v. 34 n. 2 (1992); 137-140
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
_version_ 1798951639410802688

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