Leishmania (Viannia) panamensis - induced cutaneous leishmaniasis in susceptible and resistant mouse strains
Autor(a) principal: | |
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Data de Publicação: | 1995 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/29314 |
Resumo: | We studied the susceptibility to Leishmania (Viannia) panamensis in strains of mice. The C57BL/6 strain was resistant and showed self-controlled lesion at the injected foot pad. The BALB/c and DBA/2J strains were susceptible and showed a foot swelling that started day 20 post-infection and progressed to a tumour-like lesion in later period of observation. The CBA/HJ strain was found to be of intermediary resistance. In contrast to other known cutaneous leishmaniasis in mice, the lesion in L. (V.) panamensis-infected mice was restricted to the inoculation site in the skin. In addition, we studied the development of cellular response and antibodies against Leishmania antigen in BALB/c and C57BL/6 strains. The proliferative response of lymph node cells against L. (V.) panamensis antigen was biphasic in both strains. An initial response was seen on day 20, followed by a refractory period between 40 and 80 days and a second response around fourth month post-infection. The response in the latter period was higher in C57BL/6 strain than in BALB/c strain. BALB/c strain presented much higher anti-Leishmania antibody level than C57BL/6 strain. The model and the correlation of immunological variables and the course of the infection are discussed. |
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Leishmania (Viannia) panamensis - induced cutaneous leishmaniasis in susceptible and resistant mouse strains Leishmaniose cutânea induzida pela Leishmania (Viannia) panamensis em linhagens de camundongos suscetíveis e resistentes Cutaneous leishmaniasisLeishmania (Viannia) panamensisExperimental modelMiceImmunology We studied the susceptibility to Leishmania (Viannia) panamensis in strains of mice. The C57BL/6 strain was resistant and showed self-controlled lesion at the injected foot pad. The BALB/c and DBA/2J strains were susceptible and showed a foot swelling that started day 20 post-infection and progressed to a tumour-like lesion in later period of observation. The CBA/HJ strain was found to be of intermediary resistance. In contrast to other known cutaneous leishmaniasis in mice, the lesion in L. (V.) panamensis-infected mice was restricted to the inoculation site in the skin. In addition, we studied the development of cellular response and antibodies against Leishmania antigen in BALB/c and C57BL/6 strains. The proliferative response of lymph node cells against L. (V.) panamensis antigen was biphasic in both strains. An initial response was seen on day 20, followed by a refractory period between 40 and 80 days and a second response around fourth month post-infection. The response in the latter period was higher in C57BL/6 strain than in BALB/c strain. BALB/c strain presented much higher anti-Leishmania antibody level than C57BL/6 strain. The model and the correlation of immunological variables and the course of the infection are discussed. Estudamos a susceptibilidade à Leishmania (Viannia) panamensis em linhagens de camundongos BALB/c, DBA/2J, CBA/HJ e C57BL/6. Os camundongos da linhagem C57BL/6 eram resistentes, apresentando lesões autolimitantes na pata. Os das linhagens BALB/c e DBA/2J eram suscetíveis, apresentando edema na pata, evidente aos 20 dias pós-infecção que progrediu para uma lesão tipo tumoral nas fases tardias. Os animais da linhagem CBA/HJ apresentaram resistência intermediária. Em contraste a outros modelos de leishmaniose cutânea murina, a lesão nos camundongos infectados pela L. (V.) panamensis mostrou ser restrita ao local de inoculação na pele. Estudamos também o desenvolvimento de resposta celular e anticorpos anti-Leishmania nas linhagens BALB/c c C57BL/6. A resposta proliferativa de células do linfonodo a antígenos de L. (V.) panamensis foi bifásica em ambas as linhagens. Uma resposta inicial foi observada com 20 dias de infecção, seguida por uma fase refratária entre 40 e 80 dias e uma segunda resposta ao redor do quarto mês de infecção. A resposta nesta segunda fase estava mais alta na linhagem C57BL/6 do que na BALB/c. Por outro lado, os camundongos BALB/c apresentaram níveis de anticorpo anti-Leishmania muito mais elevados que os da linhagem C57BL/6. O modelo e a correlação das variáveis imunológicas com o curso da infecção são discutidos. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1995-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/29314Revista do Instituto de Medicina Tropical de São Paulo; Vol. 37 No. 6 (1995); 475-481 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 37 Núm. 6 (1995); 475-481 Revista do Instituto de Medicina Tropical de São Paulo; v. 37 n. 6 (1995); 475-481 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/29314/31171Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessGoto, H.Rojas, J. I.Sporrong, L.Carreira, P. deSánchez, C.Örn, A.2012-07-02T01:41:00Zoai:revistas.usp.br:article/29314Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:51:03.760491Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Leishmania (Viannia) panamensis - induced cutaneous leishmaniasis in susceptible and resistant mouse strains Leishmaniose cutânea induzida pela Leishmania (Viannia) panamensis em linhagens de camundongos suscetíveis e resistentes |
title |
Leishmania (Viannia) panamensis - induced cutaneous leishmaniasis in susceptible and resistant mouse strains |
spellingShingle |
Leishmania (Viannia) panamensis - induced cutaneous leishmaniasis in susceptible and resistant mouse strains Goto, H. Cutaneous leishmaniasis Leishmania (Viannia) panamensis Experimental model Mice Immunology |
title_short |
Leishmania (Viannia) panamensis - induced cutaneous leishmaniasis in susceptible and resistant mouse strains |
title_full |
Leishmania (Viannia) panamensis - induced cutaneous leishmaniasis in susceptible and resistant mouse strains |
title_fullStr |
Leishmania (Viannia) panamensis - induced cutaneous leishmaniasis in susceptible and resistant mouse strains |
title_full_unstemmed |
Leishmania (Viannia) panamensis - induced cutaneous leishmaniasis in susceptible and resistant mouse strains |
title_sort |
Leishmania (Viannia) panamensis - induced cutaneous leishmaniasis in susceptible and resistant mouse strains |
author |
Goto, H. |
author_facet |
Goto, H. Rojas, J. I. Sporrong, L. Carreira, P. de Sánchez, C. Örn, A. |
author_role |
author |
author2 |
Rojas, J. I. Sporrong, L. Carreira, P. de Sánchez, C. Örn, A. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Goto, H. Rojas, J. I. Sporrong, L. Carreira, P. de Sánchez, C. Örn, A. |
dc.subject.por.fl_str_mv |
Cutaneous leishmaniasis Leishmania (Viannia) panamensis Experimental model Mice Immunology |
topic |
Cutaneous leishmaniasis Leishmania (Viannia) panamensis Experimental model Mice Immunology |
description |
We studied the susceptibility to Leishmania (Viannia) panamensis in strains of mice. The C57BL/6 strain was resistant and showed self-controlled lesion at the injected foot pad. The BALB/c and DBA/2J strains were susceptible and showed a foot swelling that started day 20 post-infection and progressed to a tumour-like lesion in later period of observation. The CBA/HJ strain was found to be of intermediary resistance. In contrast to other known cutaneous leishmaniasis in mice, the lesion in L. (V.) panamensis-infected mice was restricted to the inoculation site in the skin. In addition, we studied the development of cellular response and antibodies against Leishmania antigen in BALB/c and C57BL/6 strains. The proliferative response of lymph node cells against L. (V.) panamensis antigen was biphasic in both strains. An initial response was seen on day 20, followed by a refractory period between 40 and 80 days and a second response around fourth month post-infection. The response in the latter period was higher in C57BL/6 strain than in BALB/c strain. BALB/c strain presented much higher anti-Leishmania antibody level than C57BL/6 strain. The model and the correlation of immunological variables and the course of the infection are discussed. |
publishDate |
1995 |
dc.date.none.fl_str_mv |
1995-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/29314 |
url |
https://www.revistas.usp.br/rimtsp/article/view/29314 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/29314/31171 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 37 No. 6 (1995); 475-481 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 37 Núm. 6 (1995); 475-481 Revista do Instituto de Medicina Tropical de São Paulo; v. 37 n. 6 (1995); 475-481 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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1798951641677824000 |