Effects of non-specific immunopotentiators in experimental Schistosoma mansoni infection: I. levamisole
Autor(a) principal: | |
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Data de Publicação: | 1991 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/28795 |
Resumo: | The effects of levamisole on the histopathological changes, host's resistance and "in vivo" chemotaxis in Schistosoma mansoni experimental infection of C57B1/10 inbred mice were studied. Prophylatic treatment resulted in an increase in the number of adult worms obtained by perfusion and also increased the mortality rate (p < 0.05). The histopathological changes (liver and intestines) were similar in all the groups. A significant reduction of "in vivo" chemotaxis occurred in infected control mice as well as in those submitted to prophylatic treatment with levamisole. Chemotatic activity reached the same levels of normal control mice (non-infected and non-treated with levamisole), when the curative scheme was used. Levamisole seems to increase the susceptibility of inbred C57B1/10 mice to the infection with S. mansoni when administered prior to the infection and increase the chemotatic activity to normal levels when given after infection. |
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Effects of non-specific immunopotentiators in experimental Schistosoma mansoni infection: I. levamisole Efeitos de imunopotenciadores não específicos na infecção experimental pelo Schistosoma mansoni: I. levamisole LevamisoleSchistosoma mansoniImunopotenciadoresQuimiotaxia The effects of levamisole on the histopathological changes, host's resistance and "in vivo" chemotaxis in Schistosoma mansoni experimental infection of C57B1/10 inbred mice were studied. Prophylatic treatment resulted in an increase in the number of adult worms obtained by perfusion and also increased the mortality rate (p < 0.05). The histopathological changes (liver and intestines) were similar in all the groups. A significant reduction of "in vivo" chemotaxis occurred in infected control mice as well as in those submitted to prophylatic treatment with levamisole. Chemotatic activity reached the same levels of normal control mice (non-infected and non-treated with levamisole), when the curative scheme was used. Levamisole seems to increase the susceptibility of inbred C57B1/10 mice to the infection with S. mansoni when administered prior to the infection and increase the chemotatic activity to normal levels when given after infection. Os efeitos do levamisole nas alterações histopatológicas, resistência do hospedeiro e quimiotaxia "in vivo" foram estudados na infecção experimental pelo Schistosoma mansoni em camundongos da linhagem C57B1/10. O tratamento profilático resultou em um aumento no número de vermes adultos obtidos pela perfusão e também em uma taxa de mortalidade maior (p < 0,05). As alterações histopatológicas (fígado e intestino) foram similares em todos os grupos. Uma redução significante da quimiotaxia "in vivo" ocorreu em camundongos controles infectados, assim como naqueles submetidos a tratamento profilático com levamisole. A atividade quimiotática atingiu os mesmos níveis dos camundongos controles normais (não-infectados e não-tratados com levamisole), quando o esquema curativo foi usado. O levamisole parece aumentar a susceptibilidade de camundongos da linhagem C57B1/10 à infecção pelo S. mansoni quando administrado antes da infecção e normaliza a atividade quimiotática, quando dado após a infecção. Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo1991-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/28795Revista do Instituto de Medicina Tropical de São Paulo; Vol. 33 No. 1 (1991); 69-73 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 33 Núm. 1 (1991); 69-73 Revista do Instituto de Medicina Tropical de São Paulo; v. 33 n. 1 (1991); 69-73 1678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTporhttps://www.revistas.usp.br/rimtsp/article/view/28795/30648Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessMontenegro, Silvia M. L.Teixeira, Kirte M.Coutinho, Eridan M.Abath, Frederico G. C.Carvalho, Alexandre B. de2012-07-02T01:29:55Zoai:revistas.usp.br:article/28795Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:50:33.448719Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Effects of non-specific immunopotentiators in experimental Schistosoma mansoni infection: I. levamisole Efeitos de imunopotenciadores não específicos na infecção experimental pelo Schistosoma mansoni: I. levamisole |
title |
Effects of non-specific immunopotentiators in experimental Schistosoma mansoni infection: I. levamisole |
spellingShingle |
Effects of non-specific immunopotentiators in experimental Schistosoma mansoni infection: I. levamisole Montenegro, Silvia M. L. Levamisole Schistosoma mansoni Imunopotenciadores Quimiotaxia |
title_short |
Effects of non-specific immunopotentiators in experimental Schistosoma mansoni infection: I. levamisole |
title_full |
Effects of non-specific immunopotentiators in experimental Schistosoma mansoni infection: I. levamisole |
title_fullStr |
Effects of non-specific immunopotentiators in experimental Schistosoma mansoni infection: I. levamisole |
title_full_unstemmed |
Effects of non-specific immunopotentiators in experimental Schistosoma mansoni infection: I. levamisole |
title_sort |
Effects of non-specific immunopotentiators in experimental Schistosoma mansoni infection: I. levamisole |
author |
Montenegro, Silvia M. L. |
author_facet |
Montenegro, Silvia M. L. Teixeira, Kirte M. Coutinho, Eridan M. Abath, Frederico G. C. Carvalho, Alexandre B. de |
author_role |
author |
author2 |
Teixeira, Kirte M. Coutinho, Eridan M. Abath, Frederico G. C. Carvalho, Alexandre B. de |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Montenegro, Silvia M. L. Teixeira, Kirte M. Coutinho, Eridan M. Abath, Frederico G. C. Carvalho, Alexandre B. de |
dc.subject.por.fl_str_mv |
Levamisole Schistosoma mansoni Imunopotenciadores Quimiotaxia |
topic |
Levamisole Schistosoma mansoni Imunopotenciadores Quimiotaxia |
description |
The effects of levamisole on the histopathological changes, host's resistance and "in vivo" chemotaxis in Schistosoma mansoni experimental infection of C57B1/10 inbred mice were studied. Prophylatic treatment resulted in an increase in the number of adult worms obtained by perfusion and also increased the mortality rate (p < 0.05). The histopathological changes (liver and intestines) were similar in all the groups. A significant reduction of "in vivo" chemotaxis occurred in infected control mice as well as in those submitted to prophylatic treatment with levamisole. Chemotatic activity reached the same levels of normal control mice (non-infected and non-treated with levamisole), when the curative scheme was used. Levamisole seems to increase the susceptibility of inbred C57B1/10 mice to the infection with S. mansoni when administered prior to the infection and increase the chemotatic activity to normal levels when given after infection. |
publishDate |
1991 |
dc.date.none.fl_str_mv |
1991-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/28795 |
url |
https://www.revistas.usp.br/rimtsp/article/view/28795 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/28795/30648 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2018 Revista do Instituto de Medicina Tropical de São Paulo |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 33 No. 1 (1991); 69-73 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 33 Núm. 1 (1991); 69-73 Revista do Instituto de Medicina Tropical de São Paulo; v. 33 n. 1 (1991); 69-73 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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