Trypanosoma cruzi DTU II coinfection with bacteria producing prolonged cutaneous lesion in a healthy young male

Detalhes bibliográficos
Autor(a) principal: Rangel-Gamboa, Lucia
Data de Publicação: 2023
Outros Autores: González-Martínez, Erik-Iyair, Sánchez-Cruz, Lizbeth Cristina, Montiel-Rangel, Ana Isabel, Martínez-Hernández, Fernando
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/209441
Resumo: Chagas disease (CD) is a neglected tropical disease caused by Trypanosoma cruzi and is genetically classified in six discrete typing units (DTUs). The isolates reported in Mexico are generally associated with DTU I. We presented a case of a prolonged cutaneous lesion in a Mexican man, caused by DTU II in coinfection with Bacillus velezensis and Corynebacterium sp. The patient assessment included a complete clinical history, physical exam, laboratory tests, and a skin biopsy. In the facial tissues, intracellular parasites were revealed. The PCR tests were positive for T. cruzi in tissue and blood samples. DNA satellite sequencing was correlated with the DTU II. The initial serological tests reported negative results. However, four months later, two serological tests reported positive results. These exams were performed in different health centers. Mexico is considered an endemic area for CD; nevertheless, this is just the second cutaneous case associated with a DTU different from DTU-I noted in this country. From an ecological point of view, this fact suggests a geographical expansion of DTU II and an association with atypical skin manifestations. Further studies should be conducted to understand this exciting association between DTU-II and prolonged cutaneous expression in humans.
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spelling Trypanosoma cruzi DTU II coinfection with bacteria producing prolonged cutaneous lesion in a healthy young maleTrypanosoma cruziChagas diseaseDTU IICutaneous infectionChagas disease (CD) is a neglected tropical disease caused by Trypanosoma cruzi and is genetically classified in six discrete typing units (DTUs). The isolates reported in Mexico are generally associated with DTU I. We presented a case of a prolonged cutaneous lesion in a Mexican man, caused by DTU II in coinfection with Bacillus velezensis and Corynebacterium sp. The patient assessment included a complete clinical history, physical exam, laboratory tests, and a skin biopsy. In the facial tissues, intracellular parasites were revealed. The PCR tests were positive for T. cruzi in tissue and blood samples. DNA satellite sequencing was correlated with the DTU II. The initial serological tests reported negative results. However, four months later, two serological tests reported positive results. These exams were performed in different health centers. Mexico is considered an endemic area for CD; nevertheless, this is just the second cutaneous case associated with a DTU different from DTU-I noted in this country. From an ecological point of view, this fact suggests a geographical expansion of DTU II and an association with atypical skin manifestations. Further studies should be conducted to understand this exciting association between DTU-II and prolonged cutaneous expression in humans.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2023-03-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/rimtsp/article/view/20944110.1590/S1678-9946202365015 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 65 (2023); e15Revista do Instituto de Medicina Tropical de São Paulo; v. 65 (2023); e15Revista do Instituto de Medicina Tropical de São Paulo; Vol. 65 (2023); e151678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/209441/192241Copyright (c) 2023 Lucia Rangel-Gamboa, Erik-Iyair González-Martínez, Lizbeth Cristina Sánchez-Cruz, Ana Isabel Montiel-Rangel, Fernando Martínez-Hernándezhttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessRangel-Gamboa, Lucia González-Martínez, Erik-Iyair Sánchez-Cruz, Lizbeth Cristina Montiel-Rangel, Ana Isabel Martínez-Hernández, Fernando 2023-04-20T14:35:02Zoai:revistas.usp.br:article/209441Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2023-04-20T14:35:02Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)false
dc.title.none.fl_str_mv Trypanosoma cruzi DTU II coinfection with bacteria producing prolonged cutaneous lesion in a healthy young male
title Trypanosoma cruzi DTU II coinfection with bacteria producing prolonged cutaneous lesion in a healthy young male
spellingShingle Trypanosoma cruzi DTU II coinfection with bacteria producing prolonged cutaneous lesion in a healthy young male
Rangel-Gamboa, Lucia
Trypanosoma cruzi
Chagas disease
DTU II
Cutaneous infection
title_short Trypanosoma cruzi DTU II coinfection with bacteria producing prolonged cutaneous lesion in a healthy young male
title_full Trypanosoma cruzi DTU II coinfection with bacteria producing prolonged cutaneous lesion in a healthy young male
title_fullStr Trypanosoma cruzi DTU II coinfection with bacteria producing prolonged cutaneous lesion in a healthy young male
title_full_unstemmed Trypanosoma cruzi DTU II coinfection with bacteria producing prolonged cutaneous lesion in a healthy young male
title_sort Trypanosoma cruzi DTU II coinfection with bacteria producing prolonged cutaneous lesion in a healthy young male
author Rangel-Gamboa, Lucia
author_facet Rangel-Gamboa, Lucia
González-Martínez, Erik-Iyair
Sánchez-Cruz, Lizbeth Cristina
Montiel-Rangel, Ana Isabel
Martínez-Hernández, Fernando
author_role author
author2 González-Martínez, Erik-Iyair
Sánchez-Cruz, Lizbeth Cristina
Montiel-Rangel, Ana Isabel
Martínez-Hernández, Fernando
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Rangel-Gamboa, Lucia
González-Martínez, Erik-Iyair
Sánchez-Cruz, Lizbeth Cristina
Montiel-Rangel, Ana Isabel
Martínez-Hernández, Fernando
dc.subject.por.fl_str_mv Trypanosoma cruzi
Chagas disease
DTU II
Cutaneous infection
topic Trypanosoma cruzi
Chagas disease
DTU II
Cutaneous infection
description Chagas disease (CD) is a neglected tropical disease caused by Trypanosoma cruzi and is genetically classified in six discrete typing units (DTUs). The isolates reported in Mexico are generally associated with DTU I. We presented a case of a prolonged cutaneous lesion in a Mexican man, caused by DTU II in coinfection with Bacillus velezensis and Corynebacterium sp. The patient assessment included a complete clinical history, physical exam, laboratory tests, and a skin biopsy. In the facial tissues, intracellular parasites were revealed. The PCR tests were positive for T. cruzi in tissue and blood samples. DNA satellite sequencing was correlated with the DTU II. The initial serological tests reported negative results. However, four months later, two serological tests reported positive results. These exams were performed in different health centers. Mexico is considered an endemic area for CD; nevertheless, this is just the second cutaneous case associated with a DTU different from DTU-I noted in this country. From an ecological point of view, this fact suggests a geographical expansion of DTU II and an association with atypical skin manifestations. Further studies should be conducted to understand this exciting association between DTU-II and prolonged cutaneous expression in humans.
publishDate 2023
dc.date.none.fl_str_mv 2023-03-16
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/209441
10.1590/S1678-9946202365015
url https://www.revistas.usp.br/rimtsp/article/view/209441
identifier_str_mv 10.1590/S1678-9946202365015
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/rimtsp/article/view/209441/192241
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
publisher.none.fl_str_mv Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo
dc.source.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo; Vol. 65 (2023); e15
Revista do Instituto de Medicina Tropical de São Paulo; v. 65 (2023); e15
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 65 (2023); e15
1678-9946
0036-4665
reponame:Revista do Instituto de Medicina Tropical de São Paulo
instname:Instituto de Medicina Tropical (IMT)
instacron:IMT
instname_str Instituto de Medicina Tropical (IMT)
instacron_str IMT
institution IMT
reponame_str Revista do Instituto de Medicina Tropical de São Paulo
collection Revista do Instituto de Medicina Tropical de São Paulo
repository.name.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)
repository.mail.fl_str_mv ||revimtsp@usp.br
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