Impact of Antineoplastic Treatment on Oral Cavity and Oropharyngeal Microbiota of Head and Neck Cancer Patients: Systematic Review

Detalhes bibliográficos
Autor(a) principal: Silva, Iran Alves da
Data de Publicação: 2022
Outros Autores: Barbosa, Larissa Karine, Santos, Diego Belmiro do Nascimento, Oliveira, Sibele Ribeiro de, Mota, Cláudia Cristina Brainer de Oliveira, Peres, Adrya Lúcia
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/1581
Resumo: Introduction: A great diversity of microorganisms are found in the oral and oropharyngeal cavities, which are normally in homeostasis with other microorganisms and the host itself. Patients with head and neck cancer undergoing cancer treatment may trigger physiological changes in their bodies and impact in the resident microbiota. Objective: Systematically review studies on the impact of antineoplastic treatment on oral and oropharyngeal microbiota in patients with head and neck cancer. Method: Systematic review carried out between April and June 2020. Articles were searched in the Virtual Health Library, Google Scholar, PubMed and ScienceDirect databases in English, utilizing the descriptors “head and neck neoplasms”, “mouth neoplasms” and “microbiota” and “neoplasias de cabeca e pescoco”, “neoplasias bucais” and “microbiota” in Portuguese. Original articles available in full, published in the last decade (2010 to 2020), in Portuguese and English were selected. Results: 8 articles were included in this review. Most of studies have shown quantitative changes in resident microorganisms or invasion of exogenous bacteria in patients in antineoplastic treatment; uncontrolled microbiota homeostasis triggered cariogenic and inflammatory processes in the mucosa. Conclusion: Changes in the microbiome of the oral cavity and oropharyngeal resulting from antineoplastic treatment may be predisposing factors for adverse effects as the development of caries and oral mucositis.
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spelling Impact of Antineoplastic Treatment on Oral Cavity and Oropharyngeal Microbiota of Head and Neck Cancer Patients: Systematic ReviewImpacto del Tratamiento Antineoplástico en la Microbiota Oral y Orofaríngea de Pacientes Afectados por el Cáncer de Cabeza y Cuello: Revisión SistemáticaImpacto do Tratamento Antineoplásico na Microbiota da Cavidade Oral e Orofaríngea de Pacientes Acometidos pelo Câncer de Cabeça e Pescoço: Revisão Sistemáticaneoplasias bucaisneoplasias de cabeça e pescoçomicrobiotaantineoplásicosmouth neoplasmshead and neck neoplasmsmicrobiotaantineoplastic agentsneoplasias de la bocaneoplasias de cabeza y cuellomicrobiotaantineoplásicosIntroduction: A great diversity of microorganisms are found in the oral and oropharyngeal cavities, which are normally in homeostasis with other microorganisms and the host itself. Patients with head and neck cancer undergoing cancer treatment may trigger physiological changes in their bodies and impact in the resident microbiota. Objective: Systematically review studies on the impact of antineoplastic treatment on oral and oropharyngeal microbiota in patients with head and neck cancer. Method: Systematic review carried out between April and June 2020. Articles were searched in the Virtual Health Library, Google Scholar, PubMed and ScienceDirect databases in English, utilizing the descriptors “head and neck neoplasms”, “mouth neoplasms” and “microbiota” and “neoplasias de cabeca e pescoco”, “neoplasias bucais” and “microbiota” in Portuguese. Original articles available in full, published in the last decade (2010 to 2020), in Portuguese and English were selected. Results: 8 articles were included in this review. Most of studies have shown quantitative changes in resident microorganisms or invasion of exogenous bacteria in patients in antineoplastic treatment; uncontrolled microbiota homeostasis triggered cariogenic and inflammatory processes in the mucosa. Conclusion: Changes in the microbiome of the oral cavity and oropharyngeal resulting from antineoplastic treatment may be predisposing factors for adverse effects as the development of caries and oral mucositis.Introducción: Las cavidades bucal y orofaríngea presentan una gran diversidad de microorganismos que normalmente se encuentran en homeostasis con otros microorganismos y su propio hospedador, sin embargo, los pacientes con cáncer de cabeza y cuello sometidos a tratamiento contra el cáncer pueden desencadenar cambios fisiológicos en tu cuerpo, así como también impactos en su microbiota residente. Objetivo: Revisar sistemáticamente los estudios sobre el impacto del tratamiento antineoplásico en la microbiota oral y orofaríngea en pacientes con cáncer de cabeza y cuello. Método: Revisión sistemática realizada entre abril y junio de 2020. Se buscaron artículos en las bases de datos de la Biblioteca Virtual en Salud, Google Scholar, PubMed y ScienceDirect. Se utilizaron los descriptores “head and neck neoplasms“, “mouth neoplasms” and “microbiota” en inglés y “neoplasias de cabeça e pescoço”, “neoplasias bucais” e “microbiota” en portugués. Incluyeron artículos originales y disponibles en su totalidad, publicados en la última década (2010 a 2020), en portugués e inglés. Resultados: En esta revisión se incluyeron ocho artículos. Así, la mayoría de los estudios han mostrado cambios en el numero de microorganismos residentes o invasión de bacterias exógenas en pacientes sometidos a tratamiento antineoplásico, la homeostasis de la microbiota sin controle desencadena procesos cariogénicos e inflamatorios en la mucoso. Conclusión: Los cambios en el microbioma de la cavidad oral y orofaríngea por el tratamiento antineoplásico pueden ser factores predisponentes a los efectos adversos en el individuo, como el desarrollo de caries y mucositis oral.  Introdução: As cavidades oral e orofaringea apresentam uma grande diversidade de micro-organismos que se encontram normalmente em homeostase com outros micro-organismos e o próprio hospedeiro, contudo, pacientes com câncer de cabeça e pescoço submetidos ao tratamento oncológico podem desencadear modificações fisiológicas nos seus organismos, assim como impactos na sua microbiota residente. Objetivo: Revisar sistematicamente os estudos sobre o impacto provocado pelo tratamento antineoplásico sobre a microbiota oral e orofaríngea em pacientes com câncer de cabeça e pescoço. Método: Revisão sistemática, realizada entre abril e junho de 2020. Busca nas bases de dados Biblioteca Virtual em Saúde, Google Acadêmico, PubMed e ScienceDirect. Utilizaram-se os descritores “head and neck neoplasms”, “mouth neoplasms” e “microbiota” em inglês; e “neoplasias de cabeça e pescoço”, “neoplasias bucais” e “microbiota” em português. Foram selecionados artigos originais e disponíveis na integra, publicados na última década (2010 a 2020), nos idiomas português e inglês. Resultados: Foram incluídos oito artigos nesta revisão. Assim, a maioria dos estudos apresentou alterações na quantidade de micro-organismos residentes ou invasão de bactérias exógenas nos pacientes submetidos ao tratamento antineoplásico; o descontrole da homeostase da microbiota desencadeou processos cardiogênicos e inflamatórios na mucosa. Conclusão: As alterações no microbioma da cavidade oral e orofaríngea advindas do tratamento antineoplásico podem ser fatores de predisposição a efeitos adversos no individuo, como desenvolvimento de carie e mucosite oral.INCA2022-02-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfapplication/pdftext/htmlhttps://rbc.inca.gov.br/index.php/revista/article/view/158110.32635/2176-9745.RBC.2022v68n1.1581Revista Brasileira de Cancerologia; Vol. 68 No. 1 (2022): Jan./Feb./Mar.; e-161581Revista Brasileira de Cancerologia; Vol. 68 Núm. 1 (2022): ene./feb./mar.; e-161581Revista Brasileira de Cancerologia; v. 68 n. 1 (2022): jan./fev./mar.; e-1615812176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporenghttps://rbc.inca.gov.br/index.php/revista/article/view/1581/1586https://rbc.inca.gov.br/index.php/revista/article/view/1581/1925https://rbc.inca.gov.br/index.php/revista/article/view/1581/2422Copyright (c) 2022 Revista Brasileira de Cancerologiahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSilva, Iran Alves da Barbosa, Larissa Karine Santos, Diego Belmiro do Nascimento Oliveira, Sibele Ribeiro de Mota, Cláudia Cristina Brainer de Oliveira Peres, Adrya Lúcia 2022-11-25T18:50:32Zoai:rbc.inca.gov.br:article/1581Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2022-11-25T18:50:32Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Impact of Antineoplastic Treatment on Oral Cavity and Oropharyngeal Microbiota of Head and Neck Cancer Patients: Systematic Review
Impacto del Tratamiento Antineoplástico en la Microbiota Oral y Orofaríngea de Pacientes Afectados por el Cáncer de Cabeza y Cuello: Revisión Sistemática
Impacto do Tratamento Antineoplásico na Microbiota da Cavidade Oral e Orofaríngea de Pacientes Acometidos pelo Câncer de Cabeça e Pescoço: Revisão Sistemática
title Impact of Antineoplastic Treatment on Oral Cavity and Oropharyngeal Microbiota of Head and Neck Cancer Patients: Systematic Review
spellingShingle Impact of Antineoplastic Treatment on Oral Cavity and Oropharyngeal Microbiota of Head and Neck Cancer Patients: Systematic Review
Silva, Iran Alves da
neoplasias bucais
neoplasias de cabeça e pescoço
microbiota
antineoplásicos
mouth neoplasms
head and neck neoplasms
microbiota
antineoplastic agents
neoplasias de la boca
neoplasias de cabeza y cuello
microbiota
antineoplásicos
title_short Impact of Antineoplastic Treatment on Oral Cavity and Oropharyngeal Microbiota of Head and Neck Cancer Patients: Systematic Review
title_full Impact of Antineoplastic Treatment on Oral Cavity and Oropharyngeal Microbiota of Head and Neck Cancer Patients: Systematic Review
title_fullStr Impact of Antineoplastic Treatment on Oral Cavity and Oropharyngeal Microbiota of Head and Neck Cancer Patients: Systematic Review
title_full_unstemmed Impact of Antineoplastic Treatment on Oral Cavity and Oropharyngeal Microbiota of Head and Neck Cancer Patients: Systematic Review
title_sort Impact of Antineoplastic Treatment on Oral Cavity and Oropharyngeal Microbiota of Head and Neck Cancer Patients: Systematic Review
author Silva, Iran Alves da
author_facet Silva, Iran Alves da
Barbosa, Larissa Karine
Santos, Diego Belmiro do Nascimento
Oliveira, Sibele Ribeiro de
Mota, Cláudia Cristina Brainer de Oliveira
Peres, Adrya Lúcia
author_role author
author2 Barbosa, Larissa Karine
Santos, Diego Belmiro do Nascimento
Oliveira, Sibele Ribeiro de
Mota, Cláudia Cristina Brainer de Oliveira
Peres, Adrya Lúcia
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Iran Alves da
Barbosa, Larissa Karine
Santos, Diego Belmiro do Nascimento
Oliveira, Sibele Ribeiro de
Mota, Cláudia Cristina Brainer de Oliveira
Peres, Adrya Lúcia
dc.subject.por.fl_str_mv neoplasias bucais
neoplasias de cabeça e pescoço
microbiota
antineoplásicos
mouth neoplasms
head and neck neoplasms
microbiota
antineoplastic agents
neoplasias de la boca
neoplasias de cabeza y cuello
microbiota
antineoplásicos
topic neoplasias bucais
neoplasias de cabeça e pescoço
microbiota
antineoplásicos
mouth neoplasms
head and neck neoplasms
microbiota
antineoplastic agents
neoplasias de la boca
neoplasias de cabeza y cuello
microbiota
antineoplásicos
description Introduction: A great diversity of microorganisms are found in the oral and oropharyngeal cavities, which are normally in homeostasis with other microorganisms and the host itself. Patients with head and neck cancer undergoing cancer treatment may trigger physiological changes in their bodies and impact in the resident microbiota. Objective: Systematically review studies on the impact of antineoplastic treatment on oral and oropharyngeal microbiota in patients with head and neck cancer. Method: Systematic review carried out between April and June 2020. Articles were searched in the Virtual Health Library, Google Scholar, PubMed and ScienceDirect databases in English, utilizing the descriptors “head and neck neoplasms”, “mouth neoplasms” and “microbiota” and “neoplasias de cabeca e pescoco”, “neoplasias bucais” and “microbiota” in Portuguese. Original articles available in full, published in the last decade (2010 to 2020), in Portuguese and English were selected. Results: 8 articles were included in this review. Most of studies have shown quantitative changes in resident microorganisms or invasion of exogenous bacteria in patients in antineoplastic treatment; uncontrolled microbiota homeostasis triggered cariogenic and inflammatory processes in the mucosa. Conclusion: Changes in the microbiome of the oral cavity and oropharyngeal resulting from antineoplastic treatment may be predisposing factors for adverse effects as the development of caries and oral mucositis.
publishDate 2022
dc.date.none.fl_str_mv 2022-02-23
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Revisão de literatura
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1581
10.32635/2176-9745.RBC.2022v68n1.1581
url https://rbc.inca.gov.br/index.php/revista/article/view/1581
identifier_str_mv 10.32635/2176-9745.RBC.2022v68n1.1581
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/1581/1586
https://rbc.inca.gov.br/index.php/revista/article/view/1581/1925
https://rbc.inca.gov.br/index.php/revista/article/view/1581/2422
dc.rights.driver.fl_str_mv Copyright (c) 2022 Revista Brasileira de Cancerologia
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2022 Revista Brasileira de Cancerologia
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
text/html
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 68 No. 1 (2022): Jan./Feb./Mar.; e-161581
Revista Brasileira de Cancerologia; Vol. 68 Núm. 1 (2022): ene./feb./mar.; e-161581
Revista Brasileira de Cancerologia; v. 68 n. 1 (2022): jan./fev./mar.; e-161581
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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