Breast Cancer: Tumor Markers (Literature Review)

Detalhes bibliográficos
Autor(a) principal: Eisenberg, Ana Lúcia Amaral
Data de Publicação: 2001
Outros Autores: Koifman, Sérgio
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Brasileira de Cancerologia (Online)
Texto Completo: https://rbc.inca.gov.br/index.php/revista/article/view/2300
Resumo: The identification of markers which could predict the behaviour of tumors, specially breast malignancies, is important mainly because of the variability of progression of the disease. Some tumour markers and their prognostic power are discussed mainly those that use immunohistochemical method and a specimen fixed in formaldehyde and imbedded in parafine. Hormonal receptors are less subject to doubt and those tomours which are positive for these markers are, generally, smaller, whith a lower histologic and nuclear grade, a better response to hormone therapy and a better prognosis. Other tumour markers present controversies about their efficacy, but many papers link their presence to high histological grade malignancies and a poor prognosis. Different oppinions found in the literature are discussed and it may be concluded that more studies are needed before tumour markers could be used as prognostic factors in breast cancer.
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spelling Breast Cancer: Tumor Markers (Literature Review) Câncer de Mama: Marcadores Tumorais (Revisão de Literatura) Neoplasias MamáriasMarcadores Biológicos de TumorReceptores Hormonaisc-erbB-2PCNAp53Breast NeoplasmsTumor Markers, BiologicalHormonal Receptorsc-erbB-2PCNAp53The identification of markers which could predict the behaviour of tumors, specially breast malignancies, is important mainly because of the variability of progression of the disease. Some tumour markers and their prognostic power are discussed mainly those that use immunohistochemical method and a specimen fixed in formaldehyde and imbedded in parafine. Hormonal receptors are less subject to doubt and those tomours which are positive for these markers are, generally, smaller, whith a lower histologic and nuclear grade, a better response to hormone therapy and a better prognosis. Other tumour markers present controversies about their efficacy, but many papers link their presence to high histological grade malignancies and a poor prognosis. Different oppinions found in the literature are discussed and it may be concluded that more studies are needed before tumour markers could be used as prognostic factors in breast cancer.A identificação de marcadores que possam predizer o comportamento dos tumores é especialmente importante em câncer de mama devido, sobretudo, à variabilidade na progressão clínica da doença. Alguns marcadores tumorais e suas relações com o prognóstico são discutidos, dando-se ênfase àqueles que utilizam, para sua detecção, o método imuno-histoquímico e onde possa ser empregado material fixado em formol e embebido em parafina (material de arquivo). Os receptores hormonais (RH) são os menos polêmicos e os tumores positivos para estes marcadores, geralmente, apresentam menor tamanho, menor grau histológico e nuclear, uma melhor resposta à terapia hormonal e um melhor prognóstico. Para os outros marcadores tumorais aqui apresentados (c-erbB-2, catepsina D, MIB-1, PCNA, p53) existem muitas controvérsias, mas parte da literatura associa sua presença com tumores de alto grau histológico e com um pior prognóstico. As divergências existentes na literatura são discutidas e chega-se a conclusão que mais estudos são necessários antes que os marcadores tumorais possam ser utilizados como fatores prognósticos do câncer de mama.INCA2001-12-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionRevisão de literaturaapplication/pdfhttps://rbc.inca.gov.br/index.php/revista/article/view/230010.32635/2176-9745.RBC.2001v47n4.2300Revista Brasileira de Cancerologia; Vol. 47 No. 4 (2001): Oct./Nov./Dec.; 377-388Revista Brasileira de Cancerologia; Vol. 47 Núm. 4 (2001): oct./nov./dic.; 377-388Revista Brasileira de Cancerologia; v. 47 n. 4 (2001): out./nov./dez.; 377-3882176-9745reponame:Revista Brasileira de Cancerologia (Online)instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)instacron:INCAporhttps://rbc.inca.gov.br/index.php/revista/article/view/2300/1433Eisenberg, Ana Lúcia AmaralKoifman, Sérgioinfo:eu-repo/semantics/openAccess2021-11-29T20:40:17Zoai:rbc.inca.gov.br:article/2300Revistahttps://rbc.inca.gov.br/index.php/revistaPUBhttps://rbc.inca.gov.br/index.php/revista/oairbc@inca.gov.br0034-71162176-9745opendoar:2021-11-29T20:40:17Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)false
dc.title.none.fl_str_mv Breast Cancer: Tumor Markers (Literature Review)
Câncer de Mama: Marcadores Tumorais (Revisão de Literatura)
title Breast Cancer: Tumor Markers (Literature Review)
spellingShingle Breast Cancer: Tumor Markers (Literature Review)
Eisenberg, Ana Lúcia Amaral
Neoplasias Mamárias
Marcadores Biológicos de Tumor
Receptores Hormonais
c-erbB-2
PCNA
p53
Breast Neoplasms
Tumor Markers, Biological
Hormonal Receptors
c-erbB-2
PCNA
p53
title_short Breast Cancer: Tumor Markers (Literature Review)
title_full Breast Cancer: Tumor Markers (Literature Review)
title_fullStr Breast Cancer: Tumor Markers (Literature Review)
title_full_unstemmed Breast Cancer: Tumor Markers (Literature Review)
title_sort Breast Cancer: Tumor Markers (Literature Review)
author Eisenberg, Ana Lúcia Amaral
author_facet Eisenberg, Ana Lúcia Amaral
Koifman, Sérgio
author_role author
author2 Koifman, Sérgio
author2_role author
dc.contributor.author.fl_str_mv Eisenberg, Ana Lúcia Amaral
Koifman, Sérgio
dc.subject.por.fl_str_mv Neoplasias Mamárias
Marcadores Biológicos de Tumor
Receptores Hormonais
c-erbB-2
PCNA
p53
Breast Neoplasms
Tumor Markers, Biological
Hormonal Receptors
c-erbB-2
PCNA
p53
topic Neoplasias Mamárias
Marcadores Biológicos de Tumor
Receptores Hormonais
c-erbB-2
PCNA
p53
Breast Neoplasms
Tumor Markers, Biological
Hormonal Receptors
c-erbB-2
PCNA
p53
description The identification of markers which could predict the behaviour of tumors, specially breast malignancies, is important mainly because of the variability of progression of the disease. Some tumour markers and their prognostic power are discussed mainly those that use immunohistochemical method and a specimen fixed in formaldehyde and imbedded in parafine. Hormonal receptors are less subject to doubt and those tomours which are positive for these markers are, generally, smaller, whith a lower histologic and nuclear grade, a better response to hormone therapy and a better prognosis. Other tumour markers present controversies about their efficacy, but many papers link their presence to high histological grade malignancies and a poor prognosis. Different oppinions found in the literature are discussed and it may be concluded that more studies are needed before tumour markers could be used as prognostic factors in breast cancer.
publishDate 2001
dc.date.none.fl_str_mv 2001-12-28
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Revisão de literatura
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/2300
10.32635/2176-9745.RBC.2001v47n4.2300
url https://rbc.inca.gov.br/index.php/revista/article/view/2300
identifier_str_mv 10.32635/2176-9745.RBC.2001v47n4.2300
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rbc.inca.gov.br/index.php/revista/article/view/2300/1433
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv INCA
publisher.none.fl_str_mv INCA
dc.source.none.fl_str_mv Revista Brasileira de Cancerologia; Vol. 47 No. 4 (2001): Oct./Nov./Dec.; 377-388
Revista Brasileira de Cancerologia; Vol. 47 Núm. 4 (2001): oct./nov./dic.; 377-388
Revista Brasileira de Cancerologia; v. 47 n. 4 (2001): out./nov./dez.; 377-388
2176-9745
reponame:Revista Brasileira de Cancerologia (Online)
instname:Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron:INCA
instname_str Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
instacron_str INCA
institution INCA
reponame_str Revista Brasileira de Cancerologia (Online)
collection Revista Brasileira de Cancerologia (Online)
repository.name.fl_str_mv Revista Brasileira de Cancerologia (Online) - Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA)
repository.mail.fl_str_mv rbc@inca.gov.br
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