Biological activities of lignoids from amazon Myristicaceae species: Virola michelii, V. mollissima, V. pavonis and Iryanthera juruensis

• Autor(a) principal: Morais, Sabrina K.R.
• Data de Publicação: 2009
• Outros Autores: Teixeira, Ana F., Torres, Zelina Edos S., Nunomura, Sergio Massayoshi, Yamashiro-Kanashiro, Edite Hatsumi G., Lauletta Lindoso, José Angelo, Yoshida, Massayoshi
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional do INPA
• Texto Completo: https://repositorio.inpa.gov.br/handle/1/16317

This work revisits the fruits of Iryanthera juruensis and Virola pavonis and the leaves from V. michelii, as well as describing a study of the fruits of V. mollissima. In I. juruensis aryltetraline neolignan (1) and tetrahydrofuran neolignan (2), were found while from V. pavonis neolignans of benzofuran type (6-9), the tetrahydrofuran type (2, 11-13, 17) and the biphenyl type (10), in addition to diastereoisomers of the 8.O.4'-oxyneolignan type (14 and 15) and others were isolated. The V. mollissima accumulates the aryltetralone neolignan 4 and its seco derivative (5). The lignoids 1 and 2 obtained from I. juruensis arils possess antileishmanial activity against the promastigote form of Leishmania amazonensis. ©2009 Sociedade Brasileira de Química.