In vitro and in vivo anti-malarial activity of plants from the Brazilian Amazon.

• Autor(a) principal: LIMA, R. B. S.
• Data de Publicação: 2015
• Outros Autores: SILVA, L. F. R. e, MELO, M. R. S., COSTA, J. S., PICANÇO, N. S., LIMA, E. S., VASCONCELLOS, M. C., BOLETI, A. P. A., SANTOS, J. M. P., AMORIM, R. C. N., CHAVES, F. C. M., COUTINHO, J. P., TADEI, W. P., KRETTLI, A. U., POHLIT, A. M.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA - Alice)
• Texto Completo: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1032178
• topic: Antiplasmodial; Cytotoxic; Andropogon leucostachyus; Xylopia amazonica; Zanthoxylum djalma-batistae; Anacardium Occidentale; Paullinia Cupana; Croton cajucara; Plasmodium berghei; Plasmodium falciparum; malaria

The anti-malarials quinine and artemisinin were isolated from traditionally used plants (Cinchona spp. and Artemisia annua, respectively). The synthetic quinoline anti-malarials (e.g. chloroquine) and semi-synthetic artemisinin derivatives (e.g. artesunate) were developed based on these natural products. Malaria is endemic to the Amazon region where Plasmodium falciparum and Plasmodium vivax drug-resistance is of concern. There is an urgent need for new anti-malarials. Traditionally used Amazonian plants may provide new treatments for drug-resistant P. vivax and P. falciparum. Herein, the in vitro and in vivo antiplasmodial activity and cytotoxicity of medicinal plant extracts were investigated.