High proportions of asymptomatic and submicroscopic Plasmodium vivax infections in a peri-urban area of low transmission in the Brazilian Amazon

Detalhes bibliográficos
Autor(a) principal: Almeida, Anne Cristine Gomes
Data de Publicação: 2018
Outros Autores: Kuehn, Andrea, Castro, Arthur J.M., Vítor-Silva, Sheila, Figueiredo, Erick F.G., Brasil, Larissa Wanderley, Brito, Marcelo Augusto Mota, S. Sampaio, Vanderson, Bassat, Quique, Felger, Ingrid, Tadei, Wanderli Pedro, Monteiro, Wuelton Marcelo, Mueller, Ivo, Lacerda, Marcus V. G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional do INPA
Texto Completo: https://repositorio.inpa.gov.br/handle/1/15645
Resumo: Background: Population-based studies conducted in Latin America have shown a high proportion of asymptomatic and submicroscopic malarial infections. Considering efforts aiming at regional elimination, it is important to investigate the role of this asymptomatic reservoir in malaria transmission in peri-urban areas. This study aimed to estimate the prevalence of Plasmodium spp. and gametocyte burden on symptomatic and asymptomatic infections in the Brazilian Amazon. Results: Two cross-sectional household surveys (CS) were conducted including all inhabitants in a peri-urban area of Manaus, western Amazonas State, Brazil. Malaria parasites were detected by light microscopy (LM) and qPCR. Sexual stages of Plasmodium spp. were detected by LM and RT-qPCR. A total of 4083 participants were enrolled during the two surveys. In CS1, the prevalence of Plasmodium vivax infections was 4.3% (86/2010) by qPCR and 1.6% (32/2010) by LM. Fifty percent (43/86) of P. vivax infected individuals (qPCR) carried P. vivax gametocytes. In CS2, 3.4% (70/2073) of participants had qPCR-detectable P. vivax infections, of which 42.9% (30/70) of infections were gametocyte positive. The P. vivax parasite density was associated with gametocyte carriage (P < 0.001). Sixty-seven percent of P. vivax infected individuals and 53.4% of P. vivax gametocyte carriers were asymptomatic. Conclusions: This study confirms a substantial proportion of asymptomatic and submicroscopic P. vivax infections in the study area. Most asymptomatic individuals carried gametocytes and presented low asexual parasitemia. This reservoir actively contributes to malaria transmission in the Brazilian Amazon, underscoring a need to implement more efficient control and elimination strategies. © 2018 The Author(s).
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spelling Almeida, Anne Cristine GomesKuehn, AndreaCastro, Arthur J.M.Vítor-Silva, SheilaFigueiredo, Erick F.G.Brasil, Larissa WanderleyBrito, Marcelo Augusto MotaS. Sampaio, VandersonBassat, QuiqueFelger, IngridTadei, Wanderli PedroMonteiro, Wuelton MarceloMueller, IvoLacerda, Marcus V. G.2020-05-15T19:22:51Z2020-05-15T19:22:51Z2018https://repositorio.inpa.gov.br/handle/1/1564510.1186/s13071-018-2787-7Background: Population-based studies conducted in Latin America have shown a high proportion of asymptomatic and submicroscopic malarial infections. Considering efforts aiming at regional elimination, it is important to investigate the role of this asymptomatic reservoir in malaria transmission in peri-urban areas. This study aimed to estimate the prevalence of Plasmodium spp. and gametocyte burden on symptomatic and asymptomatic infections in the Brazilian Amazon. Results: Two cross-sectional household surveys (CS) were conducted including all inhabitants in a peri-urban area of Manaus, western Amazonas State, Brazil. Malaria parasites were detected by light microscopy (LM) and qPCR. Sexual stages of Plasmodium spp. were detected by LM and RT-qPCR. A total of 4083 participants were enrolled during the two surveys. In CS1, the prevalence of Plasmodium vivax infections was 4.3% (86/2010) by qPCR and 1.6% (32/2010) by LM. Fifty percent (43/86) of P. vivax infected individuals (qPCR) carried P. vivax gametocytes. In CS2, 3.4% (70/2073) of participants had qPCR-detectable P. vivax infections, of which 42.9% (30/70) of infections were gametocyte positive. The P. vivax parasite density was associated with gametocyte carriage (P < 0.001). Sixty-seven percent of P. vivax infected individuals and 53.4% of P. vivax gametocyte carriers were asymptomatic. Conclusions: This study confirms a substantial proportion of asymptomatic and submicroscopic P. vivax infections in the study area. Most asymptomatic individuals carried gametocytes and presented low asexual parasitemia. This reservoir actively contributes to malaria transmission in the Brazilian Amazon, underscoring a need to implement more efficient control and elimination strategies. © 2018 The Author(s).Volume 11, Número 1Attribution-NonCommercial-NoDerivs 3.0 Brazilhttp://creativecommons.org/licenses/by-nc-nd/3.0/br/info:eu-repo/semantics/openAccessAdolescentAdultAgedAmazonasAsymptomatic DiseaseChildControlled StudyCross-sectional StudyDisease CarrierGametocyteHouseholdHumanHuman CellMajor Clinical StudyMiddle AgedNonhumanParasite IdentificationParasite TransmissionParasitemiaPlasmodium VivaxPlasmodium Vivax MalariaChild, PreschoolPrevalenceReverse Transcription Polymerase Chain ReactionSchool ChildUrban AreaYoung AdultAsymptomatic InfectionBrasilCity PlanningFamily SizeFemaleGeneticsIsolation And PurificationMaleMicroscopyParasitemiaParasitologyPlasmodium Vivax MalariaQuestionnairesReal-time Polymerase Chain ReactionTransmissionUltrastructureProtozoal DnaAdolescentAdultAsymptomatic InfectionsBrasilChildChild, PreschoolCross-sectional StudiesDisease ReservoirsDna, ProtozoanFamily CharacteristicsFemaleHumansMalaria, VivaxMaleMicroscopyMiddle AgedParasitemiaPlasmodium VivaxPrevalenceReal-time Polymerase Chain ReactionSurveys And QuestionnairesUrban RenewalYoung AdultHigh proportions of asymptomatic and submicroscopic Plasmodium vivax infections in a peri-urban area of low transmission in the Brazilian Amazoninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleParasites and Vectorsengreponame:Repositório Institucional do INPAinstname:Instituto Nacional de Pesquisas da Amazônia (INPA)instacron:INPAORIGINALartigo-inpa.pdfartigo-inpa.pdfapplication/pdf965498https://repositorio.inpa.gov.br/bitstream/1/15645/1/artigo-inpa.pdfe291bd2098c53eedcd6366974f659d9fMD511/156452020-05-15 15:40:35.715oai:repositorio:1/15645Repositório de PublicaçõesPUBhttps://repositorio.inpa.gov.br/oai/requestopendoar:2020-05-15T19:40:35Repositório Institucional do INPA - Instituto Nacional de Pesquisas da Amazônia (INPA)false
dc.title.en.fl_str_mv High proportions of asymptomatic and submicroscopic Plasmodium vivax infections in a peri-urban area of low transmission in the Brazilian Amazon
title High proportions of asymptomatic and submicroscopic Plasmodium vivax infections in a peri-urban area of low transmission in the Brazilian Amazon
spellingShingle High proportions of asymptomatic and submicroscopic Plasmodium vivax infections in a peri-urban area of low transmission in the Brazilian Amazon
Almeida, Anne Cristine Gomes
Adolescent
Adult
Aged
Amazonas
Asymptomatic Disease
Child
Controlled Study
Cross-sectional Study
Disease Carrier
Gametocyte
Household
Human
Human Cell
Major Clinical Study
Middle Aged
Nonhuman
Parasite Identification
Parasite Transmission
Parasitemia
Plasmodium Vivax
Plasmodium Vivax Malaria
Child, Preschool
Prevalence
Reverse Transcription Polymerase Chain Reaction
School Child
Urban Area
Young Adult
Asymptomatic Infection
Brasil
City Planning
Family Size
Female
Genetics
Isolation And Purification
Male
Microscopy
Parasitemia
Parasitology
Plasmodium Vivax Malaria
Questionnaires
Real-time Polymerase Chain Reaction
Transmission
Ultrastructure
Protozoal Dna
Adolescent
Adult
Asymptomatic Infections
Brasil
Child
Child, Preschool
Cross-sectional Studies
Disease Reservoirs
Dna, Protozoan
Family Characteristics
Female
Humans
Malaria, Vivax
Male
Microscopy
Middle Aged
Parasitemia
Plasmodium Vivax
Prevalence
Real-time Polymerase Chain Reaction
Surveys And Questionnaires
Urban Renewal
Young Adult
title_short High proportions of asymptomatic and submicroscopic Plasmodium vivax infections in a peri-urban area of low transmission in the Brazilian Amazon
title_full High proportions of asymptomatic and submicroscopic Plasmodium vivax infections in a peri-urban area of low transmission in the Brazilian Amazon
title_fullStr High proportions of asymptomatic and submicroscopic Plasmodium vivax infections in a peri-urban area of low transmission in the Brazilian Amazon
title_full_unstemmed High proportions of asymptomatic and submicroscopic Plasmodium vivax infections in a peri-urban area of low transmission in the Brazilian Amazon
title_sort High proportions of asymptomatic and submicroscopic Plasmodium vivax infections in a peri-urban area of low transmission in the Brazilian Amazon
author Almeida, Anne Cristine Gomes
author_facet Almeida, Anne Cristine Gomes
Kuehn, Andrea
Castro, Arthur J.M.
Vítor-Silva, Sheila
Figueiredo, Erick F.G.
Brasil, Larissa Wanderley
Brito, Marcelo Augusto Mota
S. Sampaio, Vanderson
Bassat, Quique
Felger, Ingrid
Tadei, Wanderli Pedro
Monteiro, Wuelton Marcelo
Mueller, Ivo
Lacerda, Marcus V. G.
author_role author
author2 Kuehn, Andrea
Castro, Arthur J.M.
Vítor-Silva, Sheila
Figueiredo, Erick F.G.
Brasil, Larissa Wanderley
Brito, Marcelo Augusto Mota
S. Sampaio, Vanderson
Bassat, Quique
Felger, Ingrid
Tadei, Wanderli Pedro
Monteiro, Wuelton Marcelo
Mueller, Ivo
Lacerda, Marcus V. G.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Almeida, Anne Cristine Gomes
Kuehn, Andrea
Castro, Arthur J.M.
Vítor-Silva, Sheila
Figueiredo, Erick F.G.
Brasil, Larissa Wanderley
Brito, Marcelo Augusto Mota
S. Sampaio, Vanderson
Bassat, Quique
Felger, Ingrid
Tadei, Wanderli Pedro
Monteiro, Wuelton Marcelo
Mueller, Ivo
Lacerda, Marcus V. G.
dc.subject.eng.fl_str_mv Adolescent
Adult
Aged
Amazonas
Asymptomatic Disease
Child
Controlled Study
Cross-sectional Study
Disease Carrier
Gametocyte
Household
Human
Human Cell
Major Clinical Study
Middle Aged
Nonhuman
Parasite Identification
Parasite Transmission
Parasitemia
Plasmodium Vivax
Plasmodium Vivax Malaria
Child, Preschool
Prevalence
Reverse Transcription Polymerase Chain Reaction
School Child
Urban Area
Young Adult
Asymptomatic Infection
Brasil
City Planning
Family Size
Female
Genetics
Isolation And Purification
Male
Microscopy
Parasitemia
Parasitology
Plasmodium Vivax Malaria
Questionnaires
Real-time Polymerase Chain Reaction
Transmission
Ultrastructure
Protozoal Dna
Adolescent
Adult
Asymptomatic Infections
Brasil
Child
Child, Preschool
Cross-sectional Studies
Disease Reservoirs
Dna, Protozoan
Family Characteristics
Female
Humans
Malaria, Vivax
Male
Microscopy
Middle Aged
Parasitemia
Plasmodium Vivax
Prevalence
Real-time Polymerase Chain Reaction
Surveys And Questionnaires
Urban Renewal
Young Adult
topic Adolescent
Adult
Aged
Amazonas
Asymptomatic Disease
Child
Controlled Study
Cross-sectional Study
Disease Carrier
Gametocyte
Household
Human
Human Cell
Major Clinical Study
Middle Aged
Nonhuman
Parasite Identification
Parasite Transmission
Parasitemia
Plasmodium Vivax
Plasmodium Vivax Malaria
Child, Preschool
Prevalence
Reverse Transcription Polymerase Chain Reaction
School Child
Urban Area
Young Adult
Asymptomatic Infection
Brasil
City Planning
Family Size
Female
Genetics
Isolation And Purification
Male
Microscopy
Parasitemia
Parasitology
Plasmodium Vivax Malaria
Questionnaires
Real-time Polymerase Chain Reaction
Transmission
Ultrastructure
Protozoal Dna
Adolescent
Adult
Asymptomatic Infections
Brasil
Child
Child, Preschool
Cross-sectional Studies
Disease Reservoirs
Dna, Protozoan
Family Characteristics
Female
Humans
Malaria, Vivax
Male
Microscopy
Middle Aged
Parasitemia
Plasmodium Vivax
Prevalence
Real-time Polymerase Chain Reaction
Surveys And Questionnaires
Urban Renewal
Young Adult
description Background: Population-based studies conducted in Latin America have shown a high proportion of asymptomatic and submicroscopic malarial infections. Considering efforts aiming at regional elimination, it is important to investigate the role of this asymptomatic reservoir in malaria transmission in peri-urban areas. This study aimed to estimate the prevalence of Plasmodium spp. and gametocyte burden on symptomatic and asymptomatic infections in the Brazilian Amazon. Results: Two cross-sectional household surveys (CS) were conducted including all inhabitants in a peri-urban area of Manaus, western Amazonas State, Brazil. Malaria parasites were detected by light microscopy (LM) and qPCR. Sexual stages of Plasmodium spp. were detected by LM and RT-qPCR. A total of 4083 participants were enrolled during the two surveys. In CS1, the prevalence of Plasmodium vivax infections was 4.3% (86/2010) by qPCR and 1.6% (32/2010) by LM. Fifty percent (43/86) of P. vivax infected individuals (qPCR) carried P. vivax gametocytes. In CS2, 3.4% (70/2073) of participants had qPCR-detectable P. vivax infections, of which 42.9% (30/70) of infections were gametocyte positive. The P. vivax parasite density was associated with gametocyte carriage (P < 0.001). Sixty-seven percent of P. vivax infected individuals and 53.4% of P. vivax gametocyte carriers were asymptomatic. Conclusions: This study confirms a substantial proportion of asymptomatic and submicroscopic P. vivax infections in the study area. Most asymptomatic individuals carried gametocytes and presented low asexual parasitemia. This reservoir actively contributes to malaria transmission in the Brazilian Amazon, underscoring a need to implement more efficient control and elimination strategies. © 2018 The Author(s).
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2020-05-15T19:22:51Z
dc.date.available.fl_str_mv 2020-05-15T19:22:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://repositorio.inpa.gov.br/handle/1/15645
dc.identifier.doi.none.fl_str_mv 10.1186/s13071-018-2787-7
url https://repositorio.inpa.gov.br/handle/1/15645
identifier_str_mv 10.1186/s13071-018-2787-7
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.pt_BR.fl_str_mv Volume 11, Número 1
dc.rights.driver.fl_str_mv Attribution-NonCommercial-NoDerivs 3.0 Brazil
http://creativecommons.org/licenses/by-nc-nd/3.0/br/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivs 3.0 Brazil
http://creativecommons.org/licenses/by-nc-nd/3.0/br/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Parasites and Vectors
publisher.none.fl_str_mv Parasites and Vectors
dc.source.none.fl_str_mv reponame:Repositório Institucional do INPA
instname:Instituto Nacional de Pesquisas da Amazônia (INPA)
instacron:INPA
instname_str Instituto Nacional de Pesquisas da Amazônia (INPA)
instacron_str INPA
institution INPA
reponame_str Repositório Institucional do INPA
collection Repositório Institucional do INPA
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