Phenolic compounds from Virola venosa (Myristicaceae) and evaluation of their antioxidant and enzyme inhibition potential

• Autor(a) principal: FERNANDES,Kamila Rangel Primo
• Data de Publicação: 2019
• Outros Autores: BITTERCOURT,Paulo Senna, SOUZA,Afonso Duarte Leão de, SOUZA,Antonia Queiroz Lima de, SILVA,Felipe Moura Araújo da, LIMA,Emerson Silva, ACHO,Leonard Domingo Rosales, NUNOMURA,Rita de Cássia Saraiva, TEIXEIRA,Ana Frazão, KOOLEN,Hector Henrique Ferreira
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Acta Amazonica
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672019000100048
• topic: α-glucosidase inhibition; antioxidant compounds; ferulic acid; Amazon

ABSTRACT Virola venosa, popularly known in Brazil as ucuuba-da-mata, occurs naturally in the Amazon region and has potential to provide useful natural compounds, as already known for other Virola species. Therefore, the objective of this study was to determine the chemical composition of bark and leaf extracts of V. venosa, and to test the antioxidant capacity and α-glucosidase inhibition potential of their compounds. Polar extracts showed to be more active in both assays, therefore a bioactivity-guided fractionation was performed to identify the compounds that were responsible for the recorded activities. Using a combination of LC-MS/MS analysis and isolation with NMR identification, eight phenolic compounds were identified. Assays with pure compounds of the active fraction revealed that ferulic acid was the main contributor compound to the observed bioactivity in the crude extracts.