Antinociceptive effects of saccharose and aqueous extract of Cordyline dracaenoides kunth (uvarana) in experimental models after induction of hyperalgesia using capsaicin

• Autor(a) principal: Ribeiro,Larissa Gulogurski
• Data de Publicação: 2014
• Outros Autores: Kerppers,Ivo Ilvan, Paz,Isabel de Almeida, Rolão,Marcos Paulo Polowei, Oliveira,Thais Barbosa de, Eltchechem,Camila da Luz, Pereira,Mário César da Silva
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: MedicalExpress (São Paulo. Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S2358-04292014000200091
• topic: analgesia; saccharose; uvarana

OBJECTIVE: There is evidence that sweet substances such as saccharose can enhance the analgesic properties of endogenous opioids, leading to pain relief; it is also known that Cordyline dracaenoides Kunt, commonly known as uvarana, is used in folk medicine as an anti-inflammatory and analgesic agent. The aim of the present study was to compare the antinociceptive effects of uvarana aqueous extracts vs. saccharose in rats. METHOD: Twenty-four Wistar rats were used, divided into two groups of twelve, namely a uvarana and a saccharose group. Capsaicin was used to induce hyperalgesia and the nociceptive threshold was assessed every five minutes for a total of 50 minutes Baseline values were obtained and this was followed by administration of uvarana or saccharose at threedifferent concentrations (100, 250 and 300 g/L) The nociceptive threshold was assessed using the tail flick test. RESULT: In comparison to baseline values, uvarana and saccharose provoked significant and comparable antinociceptive effects at concentrations of 250 g/L and 300 g/L, respectively. CONCLUSION: Both substances caused similar antinociceptive effects in comparison to baseline values.