Lipid: risk factor and breast cancer prevention

Detalhes bibliográficos
Autor(a) principal: Herrmann CIBEIRA, Gabriela
Data de Publicação: 2023
Outros Autores: GUARAGNA, Regina Maria
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista de Nutrição
Texto Completo: https://periodicos.puc-campinas.edu.br/nutricao/article/view/9797
Resumo: The hypothesis that a high fat diet promotes the development of postmenopausal breast cancer is supportedby case-controls studies that show a strong correlation between fat intake and breast cancer rates. On theother hand, high fat intake is not correlated with breast cancer in cohort studies. In view of these conflictingfindings, it has been difficult to propose nutritional recommendations for the prevention of breast cancer.Animal studies and recent observations in humans have shown that a diet high in polyunsaturated fatty acidsstimulates several stages in the development of mammary cancer. Some evidences show that fish oil-derivedω-3 fatty acids seem to prevent cancer by influencing the activity of enzymes and proteins related to cellproliferation. Thus, epidemiological studies that integrate the interactions of specific fatty acids with hormonecatabolism, protective nutritional factors and risk factors associated with breast cancer are needed. In thisarticle we will discuss protective factors, risk factors and qualitative and quantitative implications of dietaryfatty acids in breast cancer.
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spelling Lipid: risk factor and breast cancer preventionLipídio: fator de risco e prevenção do câncer de mamafatty acidsdietfat intakelipidsbreast neoplasmsácidos graxosdietaingestão de gorduralipídeosneoplasias mamáriasThe hypothesis that a high fat diet promotes the development of postmenopausal breast cancer is supportedby case-controls studies that show a strong correlation between fat intake and breast cancer rates. On theother hand, high fat intake is not correlated with breast cancer in cohort studies. In view of these conflictingfindings, it has been difficult to propose nutritional recommendations for the prevention of breast cancer.Animal studies and recent observations in humans have shown that a diet high in polyunsaturated fatty acidsstimulates several stages in the development of mammary cancer. Some evidences show that fish oil-derivedω-3 fatty acids seem to prevent cancer by influencing the activity of enzymes and proteins related to cellproliferation. Thus, epidemiological studies that integrate the interactions of specific fatty acids with hormonecatabolism, protective nutritional factors and risk factors associated with breast cancer are needed. In thisarticle we will discuss protective factors, risk factors and qualitative and quantitative implications of dietaryfatty acids in breast cancer.A hipótese de que uma dieta rica em gordura promova o desenvolvimento do câncer de mama na menopausa é fortalecida por estudos caso-controle, que mostram forte associação positiva entre uma dieta rica em lipídios e as taxas de incidência de câncer de mama. Por outro lado, a ingestão dietética de gordura não parece estar relacionada com o risco de câncer de mama em estudos de coorte. Em vista desses achados conflitantes, tem sido difícil propor qualquer recomendação nutricional para a prevenção do câncer de mama. Estudos com animais e observações recentes em humanos, entretanto, têm mostrado evidências de que a dieta rica em ácido graxo linoléico estimula vários estágios no desenvolvimento de câncer mamário. Alguns estudos ainda mostram que o óleo de peixe, constituído de ácidos graxos ω-3, parece prevenir o câncer pela influência sobre a atividade de enzimas e proteínas relacionadas à proliferação celular. Assim, são necessários estudos epidemiológicos que integrem as interações de ácidos graxos específicos com o catabolismo hormonal, fatores nutricionais protetores e de risco relacionados com o câncer de mama. Nesse trabalho, abordaremos os fatores protetores, de risco e as implicações quali e quantitativas dos ácidos graxos da dieta sobre o câncer de mama.Núcleo de Editoração – PUC-Campinas2023-09-20info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9797Brazilian Journal of Nutrition; Vol. 19 No. 1 (2006): Revista de NutriçãoRevista de Nutrição; Vol. 19 Núm. 1 (2006): Revista de NutriçãoRevista de Nutrição; v. 19 n. 1 (2006): Revista de Nutrição1678-9865reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMPporhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9797/7137Copyright (c) 2023 Gabriela Herrmann CIBEIRA, Regina Maria GUARAGNAhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessHerrmann CIBEIRA, Gabriela GUARAGNA, Regina Maria2023-09-20T17:23:43Zoai:ojs.periodicos.puc-campinas.edu.br:article/9797Revistahttp://www.scielo.br/rnPRIhttps://periodicos.puc-campinas.edu.br/nutricao/oai||sbi.submissionrn@puc-campinas.edu.br1678-98651415-5273opendoar:2023-09-20T17:23:43Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false
dc.title.none.fl_str_mv Lipid: risk factor and breast cancer prevention
Lipídio: fator de risco e prevenção do câncer de mama
title Lipid: risk factor and breast cancer prevention
spellingShingle Lipid: risk factor and breast cancer prevention
Herrmann CIBEIRA, Gabriela
fatty acids
diet
fat intake
lipids
breast neoplasms
ácidos graxos
dieta
ingestão de gordura
lipídeos
neoplasias mamárias
title_short Lipid: risk factor and breast cancer prevention
title_full Lipid: risk factor and breast cancer prevention
title_fullStr Lipid: risk factor and breast cancer prevention
title_full_unstemmed Lipid: risk factor and breast cancer prevention
title_sort Lipid: risk factor and breast cancer prevention
author Herrmann CIBEIRA, Gabriela
author_facet Herrmann CIBEIRA, Gabriela
GUARAGNA, Regina Maria
author_role author
author2 GUARAGNA, Regina Maria
author2_role author
dc.contributor.author.fl_str_mv Herrmann CIBEIRA, Gabriela
GUARAGNA, Regina Maria
dc.subject.por.fl_str_mv fatty acids
diet
fat intake
lipids
breast neoplasms
ácidos graxos
dieta
ingestão de gordura
lipídeos
neoplasias mamárias
topic fatty acids
diet
fat intake
lipids
breast neoplasms
ácidos graxos
dieta
ingestão de gordura
lipídeos
neoplasias mamárias
description The hypothesis that a high fat diet promotes the development of postmenopausal breast cancer is supportedby case-controls studies that show a strong correlation between fat intake and breast cancer rates. On theother hand, high fat intake is not correlated with breast cancer in cohort studies. In view of these conflictingfindings, it has been difficult to propose nutritional recommendations for the prevention of breast cancer.Animal studies and recent observations in humans have shown that a diet high in polyunsaturated fatty acidsstimulates several stages in the development of mammary cancer. Some evidences show that fish oil-derivedω-3 fatty acids seem to prevent cancer by influencing the activity of enzymes and proteins related to cellproliferation. Thus, epidemiological studies that integrate the interactions of specific fatty acids with hormonecatabolism, protective nutritional factors and risk factors associated with breast cancer are needed. In thisarticle we will discuss protective factors, risk factors and qualitative and quantitative implications of dietaryfatty acids in breast cancer.
publishDate 2023
dc.date.none.fl_str_mv 2023-09-20
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/9797
url https://periodicos.puc-campinas.edu.br/nutricao/article/view/9797
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/9797/7137
dc.rights.driver.fl_str_mv Copyright (c) 2023 Gabriela Herrmann CIBEIRA, Regina Maria GUARAGNA
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2023 Gabriela Herrmann CIBEIRA, Regina Maria GUARAGNA
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
dc.source.none.fl_str_mv Brazilian Journal of Nutrition; Vol. 19 No. 1 (2006): Revista de Nutrição
Revista de Nutrição; Vol. 19 Núm. 1 (2006): Revista de Nutrição
Revista de Nutrição; v. 19 n. 1 (2006): Revista de Nutrição
1678-9865
reponame:Revista de Nutrição
instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron:PUC_CAMP
instname_str Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron_str PUC_CAMP
institution PUC_CAMP
reponame_str Revista de Nutrição
collection Revista de Nutrição
repository.name.fl_str_mv Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
repository.mail.fl_str_mv ||sbi.submissionrn@puc-campinas.edu.br
_version_ 1799126075273379840

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